Association of white matter microstructural integrity with cognition and dementia

Power, Melinda C.; Su, Dan; Wu, Aozhou; Reid, Robert I.; Jack, Clifford R.; Knopman, David S.; Coresh, Joe; Huang, Juebin; Kantarci, Kejal; Sharrett, A. Richey; Gottesman, Rebecca; Griswold, Mike E.; Mosley, Thomas H.

doi:10.1016/j.neurobiolaging.2019.08.021

Cited by 45 publications

(35 citation statements)

References 67 publications

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“…Additionally, the use of diffusion tensor imaging to examine the microstructural integrity of white matter has revealed a pattern of alterations characteristically observed in axon-related pathologies. These changes correlate with cognitive impairment and are consistent with loss of brain connectivity (Huang and Auchus, 2007;Power et al, 2019).…”

Section: Introductionsupporting

confidence: 63%

Axonal Degeneration in AD: The Contribution of Aβ and Tau

Salvadores

Gerónimo‐Olvera

Court

2020

Front. Aging Neurosci.

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Alzheimer's disease (AD) represents the most common age-related neurodegenerative disorder, affecting around 35 million people worldwide. Despite enormous efforts dedicated to AD research over decades, there is still no cure for the disease. Misfolding and accumulation of Aβ and tau proteins in the brain constitute a defining signature of AD neuropathology, and mounting evidence has documented a link between aggregation of these proteins and neuronal dysfunction. In this context, progressive axonal degeneration has been associated with early stages of AD and linked to Aβ and tau accumulation. As the axonal degeneration mechanism has been starting to be unveiled, it constitutes a promising target for neuroprotection in AD. A comprehensive understanding of the mechanism of axonal destruction in neurodegenerative conditions is therefore critical for the development of new therapies aimed to prevent axonal loss before irreversible neuronal death occurs in AD. Here, we review current evidence of the involvement of Aβ and tau pathologies in the activation of signaling cascades that can promote axonal demise.

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Section: Introductionsupporting

confidence: 63%

Axonal Degeneration in AD: The Contribution of Aβ and Tau

Salvadores

Gerónimo‐Olvera

Court

2020

Front. Aging Neurosci.

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“…Diffusion tensor imaging (DTI) data were processed in FSL v5.0.9 (The Oxford Centre for Functional MRI of the Brain Software Library) and were corrected for eddy current and motion distortions using FSL’s eddy tool (FMRIB Software Library) ( Andersson and Sotiropoulos, 2016 ). Following tract-based spatial statistics procedures ( Smith et al, 2006 ), we created a subject-specific template in Montreal Neurological Institute space (Montreal, Canada). This was then skeletonized and thresholded at 0.3 to exclude predominantly non-white matter voxels.…”

Section: Methodsmentioning

confidence: 99%

Multiple markers contribute to risk of progression from normal to mild cognitive impairment

Rabin

Neal

Nierle

et al. 2020

NeuroImage: Clinical

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Highlights We examined the markers that optimally predict progression from normal to MCI. A LASSO Cox model was used to determine the minimum set of markers. Entorhinal thickness, Aβ burden, default network connectivity, and hippocampal volume predicted progression. These markers may enhance risk stratification in clinically normal adults.

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“…White matter (WM) neurodegeneration of associative fiber tracts in AD may result from gray matter atrophy and Wallerian degeneration (Hardy and Higgins, 1992 ). Accumulating evidence has demonstrated disrupted WM integrity in patients with AD, MCI, and preclinical AD, which is related to cognitive decline (Mayo et al, 2017 ; Brueggen et al, 2019 ; Power et al, 2019 ). Though studies have shown an association of plasma Aβ levels with WM macrostructures such as lesions, hyperintensities, and atrophy (Janelidze et al, 2016 ; Hilal et al, 2017 ; Lippa et al, 2019 ; Youn et al, 2019 ), the relationship between plasma Aβ levels and WM microstructure has not been clarified.…”

Section: Introductionmentioning

confidence: 99%

Plasma β-Amyloid Levels Associated With Structural Integrity Based on Diffusion Tensor Imaging in Subjective Cognitive Decline: The SILCODE Study

Wang

Zhao

et al. 2021

Front. Aging Neurosci.

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Background: Accumulating evidence has demonstrated that plasma β-amyloid (Aβ) levels are useful biomarkers to reflect brain amyloidosis and gray matter structure, but little is known about their correlation with subclinical white matter (WM) integrity in individuals at risk of Alzheimer's disease (AD). Here, we investigated the microstructural changes in WM between subjects with low and high plasma Aβ levels among individuals with subjective cognitive decline (SCD).Methods: This study included 142 cognitively normal individuals with SCD who underwent a battery of neuropsychological tests, plasma Aβ measurements, and diffusion tensor imaging (DTI) based on the Sino Longitudinal Study on Cognitive Decline (SILCODE). Using tract-based spatial statistics (TBSS), we compared fractional anisotropy (FA), and mean diffusivity (MD) in WM between subjects with low (N = 71) and high (N = 71) plasma Aβ levels (cut-off: 761.45 pg/ml for Aβ40 and 10.74 pg/ml for Aβ42).Results: We observed significantly decreased FA and increased MD in the high Aβ40 group compared to the low Aβ40 group in various regions, including the body, the genu, and the splenium of the corpus callosum; the superior longitudinal fasciculus; the corona radiata; the thalamic radiation; the external and internal capsules; the inferior fronto-occipital fasciculus; and the sagittal stratum [p < 0.05, familywise error (FWE) corrected]. Average FA values were associated with poor performance on executive and memory assessments. No significant differences were found in either MD or FA between the low and high Aβ42 groups.Conclusion: Our results suggest that a correlation exists between WM integrity and plasma Aβ40 levels in individuals with SCD.

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Association of white matter microstructural integrity with cognition and dementia

Cited by 45 publications

References 67 publications

Axonal Degeneration in AD: The Contribution of Aβ and Tau

Axonal Degeneration in AD: The Contribution of Aβ and Tau

Multiple markers contribute to risk of progression from normal to mild cognitive impairment

Plasma β-Amyloid Levels Associated With Structural Integrity Based on Diffusion Tensor Imaging in Subjective Cognitive Decline: The SILCODE Study

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