Association of weekly or biweekly use of 50 000 IU vitamin D3 with hypervitaminosis D

Hashemipour, Sima; Ghobadi, Arefeh; Khairkhahan, Seyyed Mohammad Reza Hadizadeh; Ranjbaran, Mehdi; Ghafelehbashi, Seyyed Hamidreza; Gheraati, Maryam

doi:10.1111/bcp.15186

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…In a study, the rates of hypervitaminosis were reported as 18.9% and 4.5% in weekly and biweekly users of 50,000 IU of Vit. D 3, respectively [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Determining the vitamin D supplementation duration to reach an adequate or optimal vitamin D status and its effect on blood lipid profiles: a longitudinal study

Saeidlou,

Vahabzadeh,

Karimi

et al. 2024

J Health Popul Nutr

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Background Recently, Serum vitamin D (Vit. D) levels evaluation and the use of Vit. D supplements have increased substantially. There is no specific guideline for the duration of Vit. D supplementation, so yet Vit. D supplementation duration has remained a critical and controversial issue. This study aimed to determine the vit. D supplementation duration to reach an adequate or optimal Vit. D status and its effect on lipid profile. Methods In this longitudinal study, 345 women with different status of Vit. D levels were enrolled and followed up for one year. Eligible participants received 50,000 IU Vit. D3 (cholecalciferol) once a month for 12 consecutive months. The serum Vit. D levels and lipid profiles were measured at baseline, 3rd, 6th, and 12th months after the intervention. Participants were categorized based on Vit. D level at baseline into deficiency (< 20 ng/mL), inadequate (20–30 ng/mL), and adequate (> 30 ng/mL) groups, and the data were compared at different times between the three groups. Results Three deficiency (n = 73), inadequate (n = 138) and adequate (n = 134) groups of participants were followed. In all participants the average amount of Vit. D level changes were 8 ng/mL after one year of supplementation. The mean changes of serum Vit. D level in 6th and 12th months vs. 3th month was as below: In deficiency group: 4.08 ± 0.85 and 10.01 ± 1.02 ng/mL; (p < 0.001), in inadequate group: 3.07 ± 0.59 and 7.26 ± 0.78 ng/mL; (p = 0.001) and in adequate group: 2.02 ± 0.88 and 6.44 ± 1.005 ng/ml; (p = 0.001). Lipid profiles were improved in three groups. So, the mean changes of lipid profiles at the end of the study comparing with the baseline were: -5.86 ± 2.09, -7.22 ± 1.43 and − 6.17 ± 1.72 (mg/dl) for LDL (p < 0.05); -12.24 ± 3.08, -13.64 ± 3.21 and − 17.81 ± 2.94 (mg/dl) for cholesterol (p < 0.05) in deficiency, inadequate and adequate groups, respectively. For triglyceride, the mean changes were − 13.24 ± 5.78 and − 15.85 ± 7.49 (mg/dl) in deficiency and adequate groups, respectively (p < 0.05). Although the triglyceride decreased in the inadequate group at the end of the study but this difference was not significant (p = 0.67). Conclusion Taking of 50,000 IU Vit. D 3 monthly for 12 months resulted in reaching its level to adequate level in both deficiency and insufficient groups; however, in the adequate group its level did not reach above than 50 ng/mL. Therefore, 50,000 IU Vit. D3 supplementation monthly for one year can have beneficial effects on lipid profiles and there is no risk of toxicity in healthy women.

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“…In a study, the rates of hypervitaminosis were reported as 18.9% and 4.5% in weekly and biweekly users of 50,000 IU of Vit. D 3, respectively [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Determining the vitamin D supplementation duration to reach an adequate or optimal vitamin D status and its effect on blood lipid profiles: a longitudinal study

Saeidlou,

Vahabzadeh,

Karimi

et al. 2024

J Health Popul Nutr

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“…Research on vitamin C and vitamin D status remains ongoing on the grounds that their deficiency may be associated with increased susceptibility to COVID-19 infection and to potentially more severe or prolonged symptoms once infected [ 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 ]. Because medical prescription is not needed for their procurement, misinformed assurances with silent contraindications about vitamin supplements could lead to harmful intakes, unsafe combinations, and misuse by the public, as seen in hypervitaminosis and intoxication case reports during the global pandemic [ 36 , 83 , 84 , 85 , 86 , 87 , 88 , 89 ].…”

Section: Discussionmentioning

confidence: 99%

Susceptibility to COVID-19 Nutrition Misinformation and Eating Behavior Change during Lockdowns: An International Web-Based Survey

Ruani

Reiß

2023

Nutrients

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To understand the susceptibility to nutrition-health misinformation related to preventing, treating, or mitigating the risk of COVID-19 during the initial lockdowns around the world, the present international web-based survey study (15 April–15 May 2020) gauged participants’ (n = 3707) level of nutrition-health misinformation discernment by presenting them with 25 statements (including unfounded or unproven claims circulated at the time), alongside the influence of information sources of varying quality on the frequency of changes in their eating behavior and the extent of misinformation held, depending on the source used for such changes. Results revealed widespread misinformation about food, eating, and health practices related to COVID-19, with the 25 statements put to participants receiving up to 43% misinformed answers (e.g., ‘It is safe to eat fruits and vegetables that have been washed with soap or diluted bleach’). Whereas higher quality information sources (nutrition scientists, nutrition professionals) had the biggest influence on eating behavior change, we found greater misinformation susceptibility when relying on poor quality sources for changing diet. Appropriate discernment of misinformation was weakest amongst participants who more frequently changed their eating behavior because of information from poor quality sources, suggesting disparities in the health risks/safety of the changes performed.

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“…It is important to elucidate this issue for two reasons, first to avoid requests for tests of serum 25(OH)D in patients indiscriminately [59]; and secondly, to prevent vitamin D toxicity reactions from overtreatment [60][61][62]. Even though vitamin D toxicity is not likely when oral supplements are taken below 2000 international units/day, before the COVID-19 pandemic, acute kidney injury due to overcorrection of hypovitaminosis D has been reported [63,64].…”

Section: Why Is It Important To Determine the Nature Of The Associati...mentioning

confidence: 99%

Association between low serum vitamin D and increased mortality and severity due to COVID-19: reverse causality?

Oscanoa

Ghashut²,

Carvajal³

et al. 2022

Disaster Emerg Med J

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Association of weekly or biweekly use of 50 000 IU vitamin D3 with hypervitaminosis D

Cited by 4 publications

References 18 publications

Determining the vitamin D supplementation duration to reach an adequate or optimal vitamin D status and its effect on blood lipid profiles: a longitudinal study

Determining the vitamin D supplementation duration to reach an adequate or optimal vitamin D status and its effect on blood lipid profiles: a longitudinal study

Susceptibility to COVID-19 Nutrition Misinformation and Eating Behavior Change during Lockdowns: An International Web-Based Survey

Association between low serum vitamin D and increased mortality and severity due to COVID-19: reverse causality?

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