Association of WDR36 polymorphisms with primary open-angle glaucoma
Pragati Garg,
Mehvish Malik,
Tasleem Raza
Abstract:Background: Various genes contribute to the pathophysiology of primary open-angle glaucoma (POAG). The WD repeat domain 36 (WDR36) gene may participate in T cell activation and, hence, in the pathogenesis of POAG. We investigated the association of two WDR36 gene single nucleotide polymorphisms (SNPs) with POAG.
Methods: This cross-sectional study recruited patients aged >40 years with POAG and investigated the rs10038177 and rs1971050 SNPs of WDR36 using polymerase chain reaction and direct DNA seque… Show more
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