Association of vitiligo with anemia, vitamin B12 deficiency, diabetes mellitus, and thyroid dysfunction in Saudi Arab patients: A case control study

Mubki, Thamer; Al-Issa, Ahmed; Mulekar, Sanjeev V.; Albargawi, Salma; Youssef, Mohammed; AlJasser, Mohammed I.

doi:10.1016/j.jdds.2017.06.001

Cited by 9 publications

(8 citation statements)

References 13 publications

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“…In our study, more than half of the patients were females (107/200 [53.5%]). Similar results have been reported from studies in Turkey (62.5%) [24] and Saudi Arabia (53.5% [19] 56% [25]). Increased number of females among vitiligo patients is may be due to the fact that females are usually more concerned about pigmentation changes of their skin.…”

Section: Discussionsupporting

confidence: 90%

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Clinical patterns and associated comorbidities of vitiligo in Kandahar, Afghanistan. A case-control study

Rahimi¹,

Farooqi²,

Fazli³

2020

Our Dermatol Online

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Background: Vitiligo is an idiopathic acquired depigmentary skin/mucous membrane disorder. Main objective of this study was to find out demographic data, clinical patterns, and comorbidities associated with vitiligo in Kandahar, Afghanistan. Material and Methods: This was a case-control study conducted in Kandahar University Teaching Hospital between July 2017-June 2018. Descriptive statistics, Chi-square test, and logistic regression were used for data analysis. Results: A total of 400 patients (200 cases and 200 controls) were recruited. Mean age ± standard deviation (SD) of cases were 21.7±13.8 with most of the patients (77/200 [38.5%]) in age group 11-20 years. Female cases were more (107/200 [53.5%]) than males. Family history of vitiligo, accompanying altered immunity and autoimmunity disorders, psychological stress, premature graying of hair, halo nevus, vitamin D deficiency, vitamin B 12 deficiency, and folate deficiency were present in 60/200 (30%), 26/195 (13.3%), 95/200 (47.5%), 31/200 (15.5%), 24/200 (12%), 22/200 (11%), 16/200 (8%), and 14/200 (7%) of the cases, respectively. Most of the patients (148/200 [74%]) had vulgaris, followed by focal (30/200 [15%]) and segmental (11/200 [5.5%]) types of vitiligo. Logistic regression analysis showed that family history, accompanying altered immunity and autoimmunity disorders, premature graying of hair, halo nevus, and atopic diathesis were the possible risk factors of vitiligo with odds ratios of 37.1, 9.0, 6.0, 13.9, and 3.9 respectively. Conclusions: Vitiligo affects women more than men, observed mostly in second decade of life. Vitiligo vulgaris is the most prevalent type.

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Section: Discussionsupporting

confidence: 90%

“…There is association of vitiligo with autoimmune disorders [25]. In our study 13.3% of the cases while 1% of the controls were having accompanying altered immunity and autoimmunity disorders which was statistically significant (p-value <0.001).…”

Section: Discussionsupporting

confidence: 44%

Clinical patterns and associated comorbidities of vitiligo in Kandahar, Afghanistan. A case-control study

Rahimi¹,

Farooqi²,

Fazli³

2020

Our Dermatol Online

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“…The 3.8% rate observed in this study is lower than the rate observed among Indian (16%) and Saudi Arabian (8%) vitiligo patients. 10,12 The observed variations of these two studies and ours could be due to differences in study methodology and genetic backgrounds.…”

Section: Discussionmentioning

confidence: 76%

Pattern of dysglycemia among Nigerian adult patients with vitiligo: a 10-year retrospective study

Amadi

Odum

2018

Int J Adv Med

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Background: The prevalence of dysglycemia among adult patients with vitiligo is higher than the general population. However, data is scarce in our region regarding this hypothesis. This study was to define the pattern of dysglycemia in adult Nigerian patients with vitiligo.Methods: The study was conducted retrospectively among vitiligo patients who visited the University of Port Harcourt Teaching Hospital between 1st January 2007 and 31st December 2016. The laboratory characteristics of this patients were evaluated. Data collected irrespective of vitiligo variant were age, sex, and fasting plasma glucose concentrations. Shapiro-Wilk test, descriptive statistics, chi-square test, Fisher’s exact test, and two-sample t-test were used for analysis. The level of p < 0.05 was considered statistically significant.Results: There were a total of 160 vitiligo patients consisting of 55 (34.4%) males and 105 (65.6%) females. The overall patients mean age was 35±1.9 years (range 19 -61 years). The mean fasting plasma glucose concentration was 5.3±1.1mmol/l. Impaired fasting plasma glucose was detected in 41(26.6%) subjects with female dominance (female 61.0% versus male 39.0%). Diabetes mellitus was documented in 6 (3.8%) subjects with no sex difference (female 50% versus male 50%).Conclusions: Dysglycemia is frequent in vitiligo patients. Screening for dysglycemia should be incorporated into the management protocol of patients with vitiligo.

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“…Segmental vitiligo is unilateral and focal in distribution [2]. The etiopathogenesis of vitiligo involves various factors, which include oxidative stress [3], autoimmune destruction of melanocytes, neural hypothesis through an accumulation of a neurochemical substance that decreases melanin production, and sympathetic nervous system activity through direct cytotoxic effect and indirectly through the generation of free radicals [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…Serum high-density lipoprotein (HDL) cholesterol level of <40 mg/dL in males and <50 mg/dL in females or drug treatment for low HDL cholesterol. 4. Blood pressure of 130/85 mmHg or drug treatment for elevated blood pressure.…”

Section: Introductionmentioning

confidence: 99%

Vitiligo: The Association With Metabolic Syndrome and the Role of Simvastatin as an Immunomodulator

Verma¹,

Hussain²,

Namiq³

et al. 2021

Cureus

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Vitiligo is an autoimmune condition primarily affecting the skin where there is destruction of melanocytes characterized by pinkish-white patches on the skin. It is associated with other autoimmune diseases such as thyroid disease, rheumatoid arthritis, diabetes mellitus, and metabolic syndrome. Metabolic syndrome is a constellation of disorders including insulin resistance, hypertension, dyslipidemia, and obesity, and is considered a leading cause of cardiovascular morbidity. Simvastatin is a potent hypolipidemic drug that also possesses immunomodulating properties and is a common drug used in dyslipidemia and cardiovascular diseases. This study aimed to assess the association between vitiligo and metabolic syndrome and explore the immunomodulating properties of simvastatin for use in vitiligo. We reviewed various articles from PubMed, ResearchGate, and Google Scholar using different keywords and Medical Subject Headings and finalized 33 studies to be used in our review. The articles selected showed a positive association between vitiligo and metabolic syndrome or one of the component diseases of metabolic syndrome. The benefits of using simvastatin were also addressed by few articles attributing to its antioxidant and immunomodulating effect. However, there was no concrete explanation justifying the association between vitiligo and metabolic syndrome due to a limited number of studies and smaller sample size. Large-scale clinical trials should be conducted to evaluate the use of simvastatin as an immunomodulator in vitiligo to prevent possible metabolic complications.

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Association of vitiligo with anemia, vitamin B12 deficiency, diabetes mellitus, and thyroid dysfunction in Saudi Arab patients: A case control study

Cited by 9 publications

References 13 publications

Clinical patterns and associated comorbidities of vitiligo in Kandahar, Afghanistan. A case-control study

Clinical patterns and associated comorbidities of vitiligo in Kandahar, Afghanistan. A case-control study

Pattern of dysglycemia among Nigerian adult patients with vitiligo: a 10-year retrospective study

Vitiligo: The Association With Metabolic Syndrome and the Role of Simvastatin as an Immunomodulator

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