Association of vitiligo, morphea, and Hashimoto's thyroiditis

Derviş, Emine; Açbay, Özer; Barut, Gul; Karaoğlu, Aynur; Ersoy, Lütfiye

doi:10.1111/j.1365-4632.2004.01973.x

Cited by 25 publications

(21 citation statements)

References 9 publications

(8 reference statements)

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“…Also, classic vitiligo can occur simultaneously with other autoimmune diseases, ie, scleroderma, alopecia areata, thyroid disease, and diabetes mellitus. 28,29 Our 3 cases of hypopigmented JLS had loss of pigment only in the lesions of localized scleroderma and not in a distribution typically seen in the setting of vitiligo (periorificial, acral), further clinical evidence that this was hypopigmented JLS and not vitiligo. Immunostaining for CD34 and FXIIIa on biopsy specimens from the 3 cases with hypopigmented lesions showed the characteristic morphea-like immunostaining pattern, confirming the diagnosis of JLS in the hypopigmented subset of JLS.…”

Section: Discussionmentioning

confidence: 91%

Clinicohistopathological correlations in juvenile localized scleroderma: Studies on a subset of children with hypopigmented juvenile localized scleroderma due to loss of epidermal melanocytes

Sung

Chen

Gilliam

et al. 2011

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 91%

Clinicohistopathological correlations in juvenile localized scleroderma: Studies on a subset of children with hypopigmented juvenile localized scleroderma due to loss of epidermal melanocytes

Sung

Chen

Gilliam

et al. 2011

Journal of the American Academy of Dermatology

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“…In general, the most frequently reported conditions are Hashimoto thyroiditis, vitiligo, and IDDM (5,(37)(38)(39)(40)(41). Cases of linear scleroderma with primary biliary cirrhosis (42), myasthenia gravis (43), and polyglandular autoimmune disease type 2 (44) have also been described.…”

Section: Discussionmentioning

confidence: 99%

Localized scleroderma in childhood is not just a skin disease

Zulian

Vallongo

Woo

et al. 2005

Arthritis & Rheumatism

326

268

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Objective. Juvenile localized scleroderma is usually considered a disease that is confined to the skin and subcutaneous tissue. We studied the prevalence and clinical features of extracutaneous manifestations in a large cohort of children with juvenile localized scleroderma.Methods. Data from a multinational study on juvenile scleroderma was used for this in-depth study. Clinical features of patients with extracutaneous manifestations were compared with those of patients who had exclusively skin involvement.Results. Seven hundred fifty patients entered the study. One hundred sixty-eight patients (22.4%) presented with a total of 193 extracutaneous manifestations, as follows: articular (47.2%), neurologic (17.1%), vascular (9.3%), ocular (8.3%), gastrointestinal (6.2%), respiratory (2.6%), cardiac (1%), and renal (1%). Other autoimmune conditions were present in 7.3% of patients. Neurologic involvement consisted of epilepsy, central nervous system vasculitis, peripheral neuropathy, vascular malformations, headache, and neuroimaging abnormalities. Ocular manifestations were episcleritis, uveitis, xerophthalmia, glaucoma, and papilledema. In more than one-fourth of these children, articular, neurologic, and ocular involvements were unrelated to the site of skin lesions. Raynaud's phenomenon was reported in 16 patients. Respiratory involvement consisted essentially of restrictive lung disease. Gastrointestinal involvement was reported in 12 patients and consisted exclusively of gastroesophageal reflux. Thirty patients (4%) had multiple extracutaneous features, but systemic sclerosis (SSc) developed in only 1 patient. In patients with extracutaneous involvement, the prevalence of antinuclear antibodies and rheumatoid factor was significantly higher than that among patients with only skin involvement. However, Scl-70 and anticentromere, markers of SSc, were not significantly increased.Conclusion. Extracutaneous manifestations of juvenile localized scleroderma developed in almost onefourth of the children in this study. These extracutaneous manifestations often were unrelated to the site of the skin lesions and sometimes were associated with multiple organ involvement. The risk of developing SSc

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“…[7][8][9][10][11] The etiologies of vitiligo and morphea are both uncertain; however, their association with autoimmune diseases favors an autoimmune hypothesis. [9,10] In the literature, it is suggested that this association is more than coincidental, and suggests an autoimmune basis for these conditions.…”

Section: Discussionmentioning

confidence: 96%

“…[3][4][5][6] Only a few reports of the co-existence of localized scleroderma and vitiligo in individual patients are on record. [7][8][9][10][11] In this report, we present a patient who had morphea and vitiligo in the setting of chronic hepatitis B virus (HBV) infection. …”

mentioning

confidence: 96%

An Uncommon Presentation of the Co-Existence of Morphea and Vitiligo in a Patient with Chronic Hepatitis B Virus Infection

Soylu

Gül

Gönül

et al. 2009

American Journal of Clinical Dermatology

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A 30-year-old man presented with indurated violaceous plaques all over his body that had been present for 7 months. The patient had also had vitiligo for 3.5 years, and hepatitis B virus (HBV) infection and cirrhosis for a 2-year period. Histopathologic examination of the indurated plaques confirmed the diagnosis of morphea. Localized scleroderma and vitiligo have only rarely been reported to occur simultaneously. Although the etiologies of vitiligo and morphea are both uncertain, their association with autoimmune diseases favors an autoimmune hypothesis. Both vitiligo and morphea might have appeared coincidentally. However, this association could be significant because it may be related to the presence of HBV and alterations in the immune system that are caused by this virus. Therefore, this rare combination of vitiligo and morphea in a patient with chronic HBV infection warrants attention because it suggests a possible immunologic association, which may merit future study.

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Association of vitiligo, morphea, and Hashimoto's thyroiditis

Cited by 25 publications

References 9 publications

Clinicohistopathological correlations in juvenile localized scleroderma: Studies on a subset of children with hypopigmented juvenile localized scleroderma due to loss of epidermal melanocytes

Clinicohistopathological correlations in juvenile localized scleroderma: Studies on a subset of children with hypopigmented juvenile localized scleroderma due to loss of epidermal melanocytes

Localized scleroderma in childhood is not just a skin disease

An Uncommon Presentation of the Co-Existence of Morphea and Vitiligo in a Patient with Chronic Hepatitis B Virus Infection

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