Association of Vitamin D, Zinc and Selenium Related Genetic Variants With COVID-19 Disease Severity

Kotur, Nikola; Skakic, Anita; Klaassen, Kristel; Gašić, Vladimir; Zukić, Branka; Škodrić-Trifunović, Vesna; Stjepanović, Mihailo; Živković, Zorica; Ostojic, Olivera; Stevanović, Goran; Lavadinović, Lidija; Pavlović, Sonja; Stanković, Biljana

doi:10.3389/fnut.2021.689419

Cited by 26 publications

(26 citation statements)

References 48 publications

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“…A recent study by Kotur and colleagues (2021) reported a significant association between specific genetic variants of DHCR7/NADSYN1 rs12785878, GC rs2282679, CYP2R1 rs10741657, and VDR rs2228570 and severe clinical outcomes among Serbian adults but not among pediatric patients [8]. The findings in this study are consistent with results of their study, though in this study no significant correlation was evident between COVID-19 clinical conditions and CYP2R1 genetic variants.…”

Section: Discussionsupporting

confidence: 90%

“…Thus, exploring the relation of genetic variants involved in vitamin D metabolism and COVID-19 severity is worth considering and might offer population-based tools to identify individuals at greater risk of developing severe disease outcomes. Such strategies, which depend on functional polymorphism, could lead to implementing future protective measures in conjunction with vaccination [4,5,8].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, vitamin D had been identified by novel genomics-guided tracing research as a promising candidate molecule through orchestrating the expression of immune-related genes with potential to reduce SARS-CoV-2 viral infection through binding to the VDR [7]. Specific variants in genes involved in vitamin D metabolism have been identified as potential risk factors for severe COVID-19 outcomes [8], but research in this area remains limited.…”

Section: Introductionmentioning

confidence: 99%

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Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents

et al. 2021

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Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin D status with severity of COVID-19. Genetic variants involved in vitamin D metabolism have been implicated as potential risk factors for severe COVID-19 outcomes. This study investigated how genetic variations in humans affected the clinical presentation of COVID-19. In total, 646 patients with SARS-CoV-2 infection were divided into two groups: noncritical COVID-19 (n = 453; 70.12%) and a critical group (n = 193; 29.87%). Genotype data on the GC, NADSYN1, VDR, and CYP2R1 genes along with data on serum 25-hydroxyvitamin D levels were compiled in patients admitted to a major hospital in the United Arab Emirates between April 2020 and January 2021. We identified 12 single-nucleotide polymorphisms associated with the critical COVID-19 condition: rs59241277, rs113574864, rs182901986, rs60349934, and rs113876500; rs4944076, rs4944997, rs4944998, rs4944979, and rs10898210; and rs11574018 and rs11574024. We report significant associations between genetic determinants of vitamin D metabolism and COVID-19 severity in the UAE population. Further research needed to clarify the mechanism of action against viral infection in vitamin D deficiency. These variants could be used with vaccination to manage the spread of SARS-CoV-2 and could be particularly valuable in populations in which vitamin D deficiency is common.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents

et al. 2021

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“…Rupture of these junctions is caused by the SARS-CoV-2 leading to ARDS and pulmonary edema [71]. High concentrations of Vitamin D may also have benefic effects such as the induction of the vasorelaxant ACE2/Ang-(1-7)/Mas receptor axis, which protects against acute lung injury and ARDS [72]. In addition, low levels of Vitamin D are associated with Se deficiency and are related to COVID-19 severity, old age, obesity, diabetes and dyslipidemia.…”

Section: Discussionmentioning

confidence: 99%

Hyperglycemia and Loss of Redox Homeostasis in COVID-19 Patients

Soto

Guarner-Lans

Díaz-Díaz

et al. 2022

Cells

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The infection with SARS-CoV-2 impairs the glucose–insulin axis and this contributes to oxidative (OS) and nitrosative (NSS) stress. Here, we evaluated changes in glucose metabolism that could promote the loss of redox homeostasis in COVID-19 patients. This was comparative cohort and analytical study that compared COVID-19 patients and healthy subjects. The study population consisted of 61 COVID-19 patients with and without comorbidities and 25 healthy subjects (HS). In all subjects the plasma glucose, insulin, 8-isoprostane, Vitamin D, H2S and 3-nitrotyrosine were determined by ELISA. The nitrites (NO2−), lipid-peroxidation (LPO), total-antioxidant-capacity (TAC), thiols, glutathione (GSH) and selenium (Se) were determined by spectrophotometry. The glucose, insulin and HOMA-IR (p < 0.001), 8-isoprostanes, 3-nitrotyrosine (p < 0.001) and LPO were increased (p = 0.02) while Vitamin D (p = 0.01), H2S, thiols, TAC, GSH and Se (p < 0.001) decreased in COVID-19 patients in comparison to HS. The SARS-CoV-2 infection resulted in alterations in the glucose–insulin axis that led to hyperglycemia, hyperinsulinemia and IR in patients with and without comorbidities. These alterations increase OS and NSS reflected in increases or decreases in some oxidative markers in plasma with major impact or fatal consequences in patients that course with metabolic syndrome. Moreover, subjects without comorbidities could have long-term alterations in the redox homeostasis after infection.

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“…A study conducted using a population of COVID-19 infected patients in UAE has discovered 12 genetic variants in Vitamin D related genes GC, NADSYN1, VDR, and CYP2R1 (Al-Anouti et al, 2021). Variants related to vitamin D status, Zinc and Selenium levels have been found in increased frequency in a study conducted using 120 Serbian individuals (Adult and paediatric) infected with Covid-19 (DHCR7/NADSYN1 rs12785878, GC rs2282679, CYP2R1 rs10741657, and VDR rs2228570 variants related to Vitamin D; PPCDC rs2120019 variant related to Zinc and DMGDH rs17823744 related to selenium) (Kotur et al, 2021).…”

Section: Host Genetic Susceptibility For Covid -19mentioning

confidence: 99%

Host Genetic Susceptibility and Impacts of Dietary Factors on Covid-19

Ranadeva¹,

Gunathilaka²

2022

IJKIU

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COVID-19, a disease caused by SARS coronavirus 2 (SARS-CoV-2) has been a virus which is causing a global issue due to the fact that it resulted in a pandemic. The SARS coronavirus 2 binds with the angiotensin-converting enzyme 2 (ACE-2) receptors expressed in various human organs including the lungs. The SARC-CoV-2 causes respiratory disease ranging from mild to life-threatening pneumonia. Covid-19 is much feared due to its ultimate outcome such as multi-organ damage as a result of the production of a high level of pro-inflammatory cytokines referred to as “cytokine storm and resulting increased mortality and morbidity. Outcomes of the COVID 19 infection are associated with several factors that include demographic, environmental, behavioural, dietary, and genetic factors. In addition, male gender, ethnicity, older age, obesity, and several chronic diseases affect the severity of the disease. Genetic susceptibility and dietary factors involved with COVID – 19 infectivity are current areas that are widely researched and likely to play a major role. Through Genome Wide Association Studies (GWAS) and other studies done worldwide, scientists have discovered variants related to the susceptibility and severity of COVID-19. Among published reports, the involvement of ACE-2, TMPRSS2, 3p21.31 gene cluster, OAS1, OAS2 and OAS3, TYK2, DPP9, IFNAR2, CCR2 TMEM189–UBE2V1 genes, IFNL4, TLR7, LZTFL1, CCHCR1, CCNG1, ACSF3, FPR1, NKG2C/HLA-E, NLRP3, DNAH7 and CLUAP1, DES and SPEG, STXBP5, TOMM7, WSB1, PIEZO1, SCN5A, APOL1, PRKRA, GC, NADSYN1, VDR, and CYP2R1, PPCDC, VDR, DMGDH is summarized in this review. Similarly, this review concluded the role of nutrition in terms of the importance of a balanced diet and functional foods, micronutrients, probiotics, and how the omega 3/omega 6 ratio helps to prevent the severity of COVID-19.

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Association of Vitamin D, Zinc and Selenium Related Genetic Variants With COVID-19 Disease Severity

Cited by 26 publications

References 48 publications

Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents

Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents

Hyperglycemia and Loss of Redox Homeostasis in COVID-19 Patients

Host Genetic Susceptibility and Impacts of Dietary Factors on Covid-19

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