Association of vitamin-D with hypothyroidism in adult female patients in north Indian population

Abstract

Background: Thyroid disorder is found to be most commonly occurring endocrine disorder in females. Thyroid hormones have an imperative position in metabolic methods in human body, and several physiological and pathological stimuli are known to influence thyroid metabolism. The increased incidence of hypovitaminosis D was diagnosed in population with hypothyroidism. Objective: To check the relation of Vitamin D in adult female patients diagnosed with hypothyroidism. Method: We recruited 60 patients and divided these patients into two groups, Group-1- Hypothyroidism patients (n=30) and Group-2- Control patients (n=30). Thyroid-Stimulating Hormone (TSH), total Triiodothyronine (T3), total Thyroxine (T4), and Vitamin D levels were estimated by automated method in Abbott ARCHITECT ci8200 machine. Results: In the present study we found patients with hypothyroidism 73.3% (n=22) has low level of Vitamin D while 26.6% (n=8) of population have normal level of Vitamin D. We could not find significant association between Vitamin D and hypothyroidism (p>0.05). Conclusion: Our study concluded that hypothyroidism has no significant role in lowering the levels of Vitamin D but we also emphasize the fact that Vitamin D should be done as routine investigation in healthy as well as hypothyroidism patients as its value was also less in control subjects.

Study of clinical profile of hypothyroidism in a tertiary care hospital, Central India

“…Most of the (65%) hypothyroid patients were belonged to obese category (BMI>25) found in the current study, most of them were moderate obesity (35.4%), our finding was concordance with the Yadav V et al [19] In our study maximum number of patients (78.1%) was belonged to upper-middle socio-economic status and most of them (65.8%) residing in urban areas, constant finding were reported by Sethi, et al [20] and Krishna JG et al [21]. Present study analysed clinical profile of all hypothyroidism patients, we have found that the most common presenting symptoms were weakness (85.8%), weight gain (69.2%), Facial irritability (57.9%), facial puffiness (47.1%) and menstrual Irregularity (45.4%), similar finding also observed by Manoj k Choudhary et al [22], and Shetty et al [23] On clinical examination commonly observed sign are weight gain (81.3%), pedal edema (47.1%), dry skin (28.3%), depression (27.5%), pallor (23.7%), and bradycardia (20.4%), accordance to other studies like: Dixit R et al [24] and Ravindra Kumar, et al [25], whereas Kumar et al [26] reported edema, dry skin and tachycardia was the predominant sign found in hypothyroidism patients. Present study found cold intolerance was reported in 16.2% cases, accordance with the Babu MG et al [27], .reported 16.6% cold intolerance in their study Infertility cases was found in 14.6% of hypothyroidism patient in the present study, concordance to the Fauzia Imtiaz et al [28], so all hypothyroid patients always worked up for infertility.…”