Association of vitamin D status in the pathogenesis of chronic obstructive pulmonary disease

Ghoneim, Adel H.; Al-Azzawi, Mahmood A.; El‐Masry, Samir; Nasr, Mohamed Y.; Abozaid, Mohamed

doi:10.1016/j.ejcdt.2015.06.004

Cited by 9 publications

(9 citation statements)

References 35 publications

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“…With the antimicrobial function of cathelicidin associated with vitamin D levels, COPD exacerbations are reduced in patients with normal vitamin D levels compared to patients with vitamin D deficiency. 7,15,16,[21][22][23] This role of vitamin D was shown in our study; there was a significant correlation between vitamin D levels and the risk of exacerbation in patients with stable COPD at Hasan Sadikin General Hospital Bandung with a value of r=−0.639 and p<0.001. Malinovschi et al stated that COPD patients with severe vitamin D deficiency were associated with frequent exacerbations and hospitalization one year before measurement of vitamin D level.…”

Section: Dovepresssupporting

confidence: 72%

“…The decrease in MMP-9 activity will have an impact on the reduction in COPD symptoms. 10,16,21,22 In our study, there was a significant negative correlation between vitamin D levels and symptoms based on CAT scores in patients with stable COPD at Hasan Sadikin General Hospital Bandung with a value of r=−0.802 and p<001. These results are in accordance with previous study with r=−0.468 and p=0.009.…”

Section: Dovepressmentioning

confidence: 45%

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Association Between Vitamin D Levels and FEV1, Number of Exacerbations, and CAT Score in Stable COPD Patients in Indonesia

Soeroto¹,

Setiawan²,

Asriputri³

et al. 2021

IJGM

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Purpose: This study aimed to assess the association between vitamin D levels and forced expiratory volume in one second (FEV1), number of exacerbations, and symptoms based on COPD assessment test (CAT) scores in stable COPD patients in Indonesia. Patients and Methods: An observational cross-sectional study was conducted. Subjects were stable COPD patients who were treated at a pulmonary clinic in a tertiary referral hospital in West Java from March to June 2018. Results: Thirty subjects were recruited this study with an average age 62±8 years. The mean vitamin D level was 20.17±8.91 ng/mL. Half of the patients had low vitamin D level (<20ng/ mL) (50%). The mean FEV1 (%) predicted value was 37.2±14. The median exacerbation per year was 1 (0-5) and symptoms based on CAT score was 14 (3-34). No correlation was found between vitamin D levels and FEV1 (%) predicted value (r=0.126, p=0.253). Vitamin D level was inversely correlated with number of exacerbations (r=−0.639, p<0.001) and CAT (r= −0.802, p<0.001). Conclusion: Low level of vitamin D was associated with more frequent exacerbation and higher CAT scores but was not associated with FEV1 (%) predicted.

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Section: Dovepresssupporting

confidence: 72%

Section: Dovepressmentioning

confidence: 45%

Association Between Vitamin D Levels and FEV1, Number of Exacerbations, and CAT Score in Stable COPD Patients in Indonesia

Soeroto¹,

Setiawan²,

Asriputri³

et al. 2021

IJGM

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“…These results agreed with those of (Ghoneim et al, 2015) who found higher levels of antioxidants in healthy plasma compared with patients with chronic obstructive pulmonary disease.…”

Section: Resultssupporting

confidence: 92%

Effective Dose of Vitamin C Against Passive Smoking

Nour

El-Assar

Zahran

2020

Alexandria Science Exchange Journal

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Objective: Ascorbic acid (AA), known as vitamin C, plays an important role in the human body. Therefore, this study aimed to estimate the beneficial effects of two levels of (AA) that can protect or cure the lung against the hazards of passive smoking in male mice. Materials and Methods: The study was done on forty male albino mice (6 weeks age and average body weight 22 ± 3 g). The mice were assigned into eight equal groups; control group, group 2was exposed to cigarette smoke for 12 weeks, and the other six groups were given low or high doses of vitamin C(0.015and 0.075 mg/g BW)before, during and after exposure to smoke. Doses were given orally via oro-gastric tube. Results: High doses of vitamin C had a protective effect when taken before and during exposure to smoke. It reduced the negative effect of smoke as indicated by the levels of TBARS and GSH in plasma and lung tissue, and the improvement of studied histological parameters. Conclusion: Ascorbic acid had no therapeutic effects after lung tissue damage due to exposure to secondhand smoke. Therefore, it is important to protect the lung from the negative effects of smoking by increasing the daily intake of vitamin C doses to 1 gram, from food rich in vitamin C like fresh fruits and vegetables.

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“…Oxidative stress protease - antiprotease imbalance, inflammation, and lung remodeling are the most important pathogenic mechanisms involved in the development of COPD although role of Vitamin D in the pathogenesis of COPD is not clear but it is believed that lower Vitamin D levels are related to regulation of each of these processes, that is, higher expression of proteases, modulation of inflammation, and increased oxidative stress[ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative stress protease - antiprotease imbalance, inflammation, and lung remodeling are the most important pathogenic mechanisms involved in the development of COPD. Lower Vitamin D levels have been related to regulation of each of these processes, that is, higher expression of proteases, modulation of inflammation, and increased oxidative stress[ 14 ]. In COPD, the risk of Vitamin D deficiency is higher than expected and is linked with disease severity [ 15 16 17 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease

Pandey

Garg

Kant

et al. 2021

Tzu Chi Medical Journal

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Objective: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Systemic inflammation and oxidant/antioxidant imbalance has been seen to play a key role in pathogenesis of COPD. The present study investigated the levels of inflammatory and antioxidant/oxidative stress biomarker in COPD patients and healthy subjects. Materials and Methods: The present study enrolled seventy COPD patients and seventy healthy controls from Department of Respiratory Medicine at a tertiary care hospital. Vitamin D, C-reactive protein (CRP), superoxide dismutase (SOD), catalase, and malondialdehyde (MDA) levels were measured in both cases and control. GraphPad PRISM version 6.01 was used for analysis of data. Results: The levels of Vitamin D, SOD, Catalase, were found to be significantly lower among the COPD patients in comparison to healthy controls while levels of MDA and CRP were significantly higher ( P = 0.0001). Conclusion: The results showed oxidant/antioxidant imbalance and Vitamin D deficiency in COPD patients. Higher levels of CRP and oxidative stress markers were observed in COPD patients in comparison to healthy controls. A biomarker based study testing the efficacy of novel antioxidant or other agents will be helpful that can modify the course of this disease.

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Association of vitamin D status in the pathogenesis of chronic obstructive pulmonary disease

Cited by 9 publications

References 35 publications

Association Between Vitamin D Levels and FEV1, Number of Exacerbations, and CAT Score in Stable COPD Patients in Indonesia

Association Between Vitamin D Levels and FEV1, Number of Exacerbations, and CAT Score in Stable COPD Patients in Indonesia

Effective Dose of Vitamin C Against Passive Smoking

Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease

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