Association of Vitamin D Receptor Gene Polymorphisms with Asthma Risk: Systematic Review and Updated Meta-analysis of Case–Control Studies

Tizaoui, Kalthoum; Berraies, A.; Hamdi, Besma; Kaabachi, Wajih; Hamzaoui, Kamel; Hamzaoui, A.

doi:10.1007/s00408-014-9648-8

Cited by 51 publications

(46 citation statements)

References 61 publications

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“…Vitamin D is involved in cell-mediated immunity where it is thought to reduce the production of inflammatory cytokines such as IL-1, IL-6, and TNF-α that are involved in the spontaneous preterm birth [14,15]. Polymorphisms in the VDR gene have been associated with autoimmune and infectious diseases such as tuberculosis, Crohn's disease, asthma or diabetes [16][17][18][19]. Maintenance of a normal pregnancy requires efficient coordination of antimicrobial and anti-inflammatory responses within the feto-placental unit.…”

Section: Discussionmentioning

confidence: 99%

Influence of Apa1 (rs7975232), Taq1 (rs731236) and Bsm1 (rs154410) polymorphisms of vitamin D receptor on preterm birth risk in the Polish population

Baczyńska-Strzecha

Kalinka

2016

Ginekol Pol

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Objectives: Vitamin D receptor (VDR) is expressed in the placenta and tissues related to the immune system occurrence of various variants of VDR may modify the effects of vitamin D on pregnancy.The aim of this study was to evaluate the association between the parturients' Apa1, Taq1, and Bsm1 polymorphisms of the VDR and their combinations and the risk of preterm birth in the Polish population. Material and methods:Determination of polymorphism for VDR was assayed using the RT-PCR method. 199 Caucasian women at childbirth were qualified:100 patients who had a spontaneous preterm birth and 99 patients who had a term birth.Results: Three separate genotypes of the Apa1, Taq1, and Bsm1 polymorphisms were detected. No significant differences in the frequency of particular genotypes in the compared groups were found. Some of the genotype combinations were significantly more frequent in the preterm group -the bb/AA/TT genotype (28.0% vs. 10.1%; p = 0.0013) and the BB/aa/tt genotype (14.0% vs. 4.04% p = 0.0277). The Bb/AA/Tt and the BB/Aa/tt genotypes were found only in the control group (16.1% and 7.0% of patients, respectively). The bb/aa/TT was significantly more frequent in the control group (2.0% vs. 11.1%; p = 0,0207). Two genotype combinations reduced the risk of preterm birth -the Bb/AA/Tt genotype by 94% (OR = 0.43, 95% CI: 0.002-0.885, p = 0.041) and the BB/Aa/tt genotype by 98% (OR = 0.029, 95% CI: 0.001-0.838, p = 0.039). Conclusions:Our result suggests that there may be a relationship between certain VDR genotype combinations and the risk of preterm birth. Further research is needed in order to substantiate this finding.

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Section: Discussionmentioning

confidence: 99%

Influence of Apa1 (rs7975232), Taq1 (rs731236) and Bsm1 (rs154410) polymorphisms of vitamin D receptor on preterm birth risk in the Polish population

Baczyńska-Strzecha

Kalinka

2016

Ginekol Pol

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“…Molecular-based epidemiological studies have identified several functional polymorphisms in the VDR [21] and have demonstrated that the variants can affect the function of the receptor by altering its affinity to vitamin D [28,29]. VDR genetic variants have previously been associated with a number of diseases including pulmonary tuberculosis, diabetes, osteoporosis, asthma, ulcerative colitis, breast and female reproductive cancers, melanoma, systemic lupus erythematous and rheumatoid arthritis, Parkinson's disease, and coronary artery disease [30][31][32][33][34][35][36][37][38][39]. Pharmacogenetic studies have shown that VDR polymorphisms can modulate the response to a number of drugs including anti-tubercular and anti-psoriatic medications, anti-osteoporotic agents in postmenopausal women, interferon and ribavirin in patients with hepatitis C, vitamin D supplementation, and calcitriol [40][41][42][43][44][45][46], as well as with statin-induced myopathy [47].…”

Section: Discussionmentioning

confidence: 99%

Nuclear receptor gene polymorphisms and warfarin dose requirements in the Quebec Warfarin Cohort

et al. 2018

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Warfarin is primarily metabolized by cytochrome 2C9, encoded by gene CYP2C9. Here, we investigated whether variants in nuclear receptor genes which regulate the expression of CYP2C9 are associated with warfarin response. We used data from 906 warfarin users from the Quebec Warfarin Cohort (QWC) and tested the association of warfarin dose requirement at 3 months following the initiation of therapy in nine nuclear receptor genes: NR1I3, NR1I2, NR3C1, ESR1, GATA4, RXRA, VDR, CEBPA, and HNF4A. Three correlated SNPs in the VDR gene (rs4760658, rs11168292, and rs11168293) were associated with dose requirements of warfarin (P = 2.68 × 10 −5 , P = 5.81 × 10 −4 , and P = 5.94 × 10, respectively). Required doses of warfarin were the highest for homozygotes of the minor allele at the VDR variants (P < 0.0026). Variants in the VDR gene were associated with the variability in response to warfarin, emphasizing the possible clinical relevance of nuclear receptor gene variants on the inter-individual variability in drug metabolism.

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“…VDRs are activated by 1,25(OH)2D3 and affect expression of over 200 genes, up regulations nearly two-thirds and down regulating one-third of those genes. Therefore, VDRs found in different alleles having different effects [12,13]. A mutated VDR in hereditary vitamin D-resistant rickets prevents induction of bronchial hyperreactivity and inflammation [14].…”

Section: Vitamin D Receptor Polymorphismmentioning

confidence: 99%

Vitamin D and Allergy

Özdemir¹

2016

MOJI

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After the modern vitamin D hypothesis firstly suggested in 1999 for the allergy pandemic, numerous conditions have been thought to be associated with vitamin D deficiency such as allergy, autoimmunity and neoplasm. Consistently, previous observational studies have linked lower vitamin D status to increased markers of atopy and allergic diseases e.g. atopic dermatitis, anaphylaxis and food allergy. Vitamin D is a "hormone" having important immunomodulatory and immunoregulatory properties. In vitamin D deficient conditions, disrupted mucosal and skin complex integrity and intercurrent infections may act synergistically with allergenic exposure to amplify sensitization risk. There has been emerging data to show that vitamin D can enhance the anti-inflammatory effects of glucocorticoids and potentially be used as adjuvant therapy in steroid-resistant severe asthma. And recent in vivo data suggest that vitamin D supplementation reduce the severity of eczema and allergic rhinitis as well as urticaria symptoms. However, there is presently inadequate evidence to support daily vitamin D supplementation in the prevention and/or treatment of allergic diseases in infants, children and adolescents.

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Association of Vitamin D Receptor Gene Polymorphisms with Asthma Risk: Systematic Review and Updated Meta-analysis of Case–Control Studies

Abstract: TaqI, BsmI, and FokI VDR polymorphisms contribute to asthma susceptibility. The association between FokI polymorphism and asthma risk is influenced by study characteristics.

Cited by 51 publications

References 61 publications

Influence of Apa1 (rs7975232), Taq1 (rs731236) and Bsm1 (rs154410) polymorphisms of vitamin D receptor on preterm birth risk in the Polish population

Influence of Apa1 (rs7975232), Taq1 (rs731236) and Bsm1 (rs154410) polymorphisms of vitamin D receptor on preterm birth risk in the Polish population

Nuclear receptor gene polymorphisms and warfarin dose requirements in the Quebec Warfarin Cohort

Vitamin D and Allergy

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