Association of vitamin D receptor<i>BsmI</i>gene polymorphism with the risk of type 2 diabetes mellitus

Zhu, Bin; Zhao, Hongda; Ou, Chao; Huang, Liuliu; Li, Peizhang; Ming, Lao

doi:10.3109/10799893.2014.919592

Cited by 16 publications

(16 citation statements)

References 13 publications

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“…Data of the present study showed that vitamin D status was significantly associated with HbA1c after adjusting for sex, age, BMI, and duration of diabetes. Data of this work correlates with another study in South Korea which explained the negative relationship between vitamin D status and glycemic control in existing T2DM, which reached a similar conclusion [29]. In addition, evidence from a number of studies has suggested a relationship between vitamin D and micro-vascular complications of T2DM.…”

Section: Resultssupporting

confidence: 87%

Vitamin D Status and its Receptor Genes BsmI, FokI, ApaI, TaqI Polymorphism in Relation to Glucose Metabolism in Obese Iraqi Type 2 Diabetes Mellitus Patients

Sz¹,

Hf²,

Ar³

2017

J Mol Genet Med

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Section: Resultssupporting

confidence: 87%

Vitamin D Status and its Receptor Genes BsmI, FokI, ApaI, TaqI Polymorphism in Relation to Glucose Metabolism in Obese Iraqi Type 2 Diabetes Mellitus Patients

Sz¹,

Hf²,

Ar³

2017

J Mol Genet Med

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“…Regarding (Taq1, Bsm1) genotypes and alleles distribution we didn’t find significant statistical differences between patients with T2DM and controls. Similarly other previous studies [23] , [24] , [26] and a Meta analysis done on 11 reports [28] did not find any significant differences regarding VDR BsmI genotypes among T2DM and controls, also Turkish investigators didn’t find association between Taq1 polymorphism and T2DM [29] .…”

Section: Discussionmentioning

confidence: 52%

Vitamin D receptor gene polymorphisms and 25(OH) vitamin D: Lack of association to glycemic control and metabolic parameters in type 2 diabetic Egyptian patients

Gendy

Sadik

Helmy

et al. 2019

Journal of Clinical & Translational Endocrinology

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BackgroundVitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been linked to type 2 diabetes mellitus (T2DM) and its metabolic parameters, however there are conflicting results therefore we aimed to evaluate VDR gene polymorphisms (Fok1, Bsm1 and Taq1) and vitamin D status in Egyptian patients with T2DM and to detect the associations of these polymorphisms to their metabolic parameters and glycemic control.Methods50 patients with T2DM and 50 healthy age matched control subjects were enrolled. FBG, 2 h –PPG, fasting lipids, Hb A1c, calcium, phosphorus, urea, creatinine, ALT, AST were measured. BMI has calculated. Serum 25 hydroxy vitamin D [25(OH)D] has measured by ELISA. VDR gene polymorphisms detection has done by polymerase chain reaction through restriction fragment length polymorphism (PCR-RFLP) technique.ResultsOur study has shown lower mean levels of 25(OH)D in patients with T2DM (28.54 ± 10.02) in comparison with control subjects (44.65 ± 7.19), p < 0.001. Vitamin D insufficiency was more prevalent in T2DM 58% than in healthy control subjects 4%. There were statistically significant differences between patients with type 2 diabetes and controls regarding the distribution of FokI genotypes and alleles (p = 0.005) and non significant difference regarding Bsm1 and Taq1. Neither VDR gene polymorphisms nor 25(OH)D showed significant association with glycemic control, fasting lipids and BMI in patients with T2DM.ConclusionsVitamin D deficiency is prevalent in Egyptian patients with T2DM. Associations were found only between VDR FokI gene polymorphism and susceptibility to Egyptian patients with T2DM. Non significant differences in VDR gene polymorphisms distribution has found regarding glycemic control and metabolic parameters.

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“…The role of VDR gene polymorphism and type 2 diabetes has been studied, but the results are not consistent among different populations. Regarding VDR BsmI gene polymorphism, two recent meta-analysis studies did not find an association with type 2 diabetes risk in Asian or Caucasian populations [ 36 , 37 ]. Heterogeneity among populations and the lack of studies to elucidate the genetic differences might explain the discrepancies between the studies [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

25-Hydroxyvitamin D3 Levels, BsmI Polymorphism and Insulin Resistance in Brazilian Amazonian Children

Cobayashi

Lourenço

Cardoso

2015

IJMS

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Vitamin D is associated with a wide range of other functions beyond bone development. We evaluated the factors associated with 25-hydroxyvitamin D levels in 974 children aged ≤10 years and the impact of BsmI polymorphism of the vitamin D receptor (VDR) gene (rs1544410) on metabolic parameters in a subsample (n: 430) with a follow-up 2 years later from the initial population-based cross-sectional study. Multiple linear regression models were used in the analyses. The prevalence (95% CI) of vitamin D deficiency, insufficiency and sufficiency of children was 11.1% (9.2–13.2), 21.8% (19.2–24.5) and 67.2% (64.1–70.1), respectively. Overall, 23% of the variation in serum 25-hydroxyvitamin D concentrations was accounted for by BsmI polymorphism β = −0.053 (95% CI) (−0.100, −0.006), maternal schooling (≥9 years) β = 0.100 (0.039, 0.161), serum vitamin E β = 0.478 (0.381, 0.574), total cholesterol concentration β = 0.232 (0.072, 0.393) and serum folate β = 0.064 (0.013, 0.115). BsmI polymorphism was positively associated with HOMA-IR β = 0.122 (0.002, 0.243) and fasting glucose concentration β = 1.696 (0.259, 3.133). In conclusion, variables related to socioeconomic level, the presence of the allele risk for BsmI and other nutrient concentrations were associated with serum 25-hydroxyvitamin D concentrations. Our results suggest that BsmI polymorphism is correlated with metabolic outcomes.

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Association of vitamin D receptorBsmIgene polymorphism with the risk of type 2 diabetes mellitus

Cited by 16 publications

References 13 publications

Vitamin D Status and its Receptor Genes BsmI, FokI, ApaI, TaqI Polymorphism in Relation to Glucose Metabolism in Obese Iraqi Type 2 Diabetes Mellitus Patients

Vitamin D Status and its Receptor Genes BsmI, FokI, ApaI, TaqI Polymorphism in Relation to Glucose Metabolism in Obese Iraqi Type 2 Diabetes Mellitus Patients

Vitamin D receptor gene polymorphisms and 25(OH) vitamin D: Lack of association to glycemic control and metabolic parameters in type 2 diabetic Egyptian patients

25-Hydroxyvitamin D3 Levels, BsmI Polymorphism and Insulin Resistance in Brazilian Amazonian Children

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