Association of vitamin�D receptor expression with inflammatory changes and prognosis of asthma

Chen, Yanhua; Xu, Tongbai

doi:10.3892/etm.2018.6867

Cited by 10 publications

(7 citation statements)

References 21 publications

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“…The studies of various international groups, reported (TNF-alpha) genes, are already identified and the known locus of it might influence the inflammatory activity. Consequently, latest studies reported that TNF-alpha is one of the genes that play a leading role in the disease development [26] The study by Chen and Xu (2018) was against our observation, which found that TNF-α was higher, while TGF-β was lower in asthmatics than control [27], and surprisingly, a recent study done by Han et al (2021) showed that IGF-1 has a beneficial role in asthmatic adults and is associated with better pulmonary functions [28]. However, the study of Mu et al (2019) proved that IGF-1 is elevated in the lungs and BAL of asthmatic mice and it inhibits phagocytosis and development of apoptotic cells after lung injury, and after using blocking antibodies to IGF-1, phagocytosis, and apoptosis improved that ultimately lead to a decrease inflammatory cells infiltration and improvement of asthma [9].…”

Section: Discussioncontrasting

confidence: 61%

Evaluation of IGF-1, TNF-α, and TGF-β Gene Expression after Oral Vitamin D Supplementation in School-Aged Children with Chronic Bronchial Asthma

Ramadan

Sallam²,

Yousef³

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Airway remodeling in children with bronchial asthma is due to the effect of inflammatory mediators and growth factors on the bronchial epithelium. Vitamin D (VitD) has immunomodulatory effect in many inflammatory diseases as bronchial asthma. The ant-inflammatory and anti-fibrotic role of VitD could prevent or improve air way remodeling in asthmatic patients. AIM: The study investigated the effect of VitD supplementation on the expression of transforming growth factor-beta (TGF-β), tumor necrosis factor-alpha (TNF-α), and insulin growth factor 1(IGF-1) and to correlate them with asthma severity and level of control. METHODS: The serum level of VitD and the mRNA expression of IGF-1, TGF-β, and TNF-α were estimated in 50 patients and 20 healthy controls control subjects using quantitative PCR in real-time. Asthmatic patients with VitD deficiency received VitD supplementation for 2 months followed by remeasurement of serum VitD and the genes expression TGF-β, TNF-α, and IGF-1. RESULT: Pre-intake of VitD and serum level of VitD were lower in all patients than control subjects (p = 0.005). VitD level was directly correlated with IGF-1 mRNA expression, which was indirectly correlated with TGF-β, r = 0.5 and −0.57; p = 0.0001 and 0.002, respectively. After VitD supplementation, the expression of the TGF-β mRNA gene was the only gene that decreased significantly (p = 0.04) together with improved asthma control and spirometric parameters. CONCLUSIONS: VitD supplementation down regulated the gene expression of TGF-β and improved asthma control level, but it did not significantly affect the gene expression of TNF-α and IGF-1.

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Section: Discussioncontrasting

confidence: 61%

Evaluation of IGF-1, TNF-α, and TGF-β Gene Expression after Oral Vitamin D Supplementation in School-Aged Children with Chronic Bronchial Asthma

Ramadan

Sallam²,

Yousef³

et al. 2022

Open Access Maced J Med Sci

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“…We recently reported the inhibition of cellular oxidative stress effects and inflammation by vitamin D in non-irradiated, and UV radiated fibroblasts [29]. Vitamin D had been reported to inhibit oxidative stress, inflammation, angiogenesis and ECM remodeling in diverse cell types or tissue [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45]. We herein extend the beneficial effects of vitamin D to melanoma cells.…”

Section: Discussionmentioning

confidence: 96%

Beneficial Regulation of Cellular Oxidative Stress Effects, and Expression of Inflammatory, Angiogenic, and the Extracellular Matrix Remodeling Proteins by 1α,25-Dihydroxyvitamin D3 in a Melanoma Cell Line

Philips

Keller

et al. 2020

Molecules

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The causes of cancer include the cellular accumulation reactive oxygen species (ROS), which overrides the cellular antioxidants such as superoxide dismutase, from intrinsic aging, genetics, and exposure to environmental pollutants and ultraviolet (UV) radiation. The ROS damage biomolecules such as DNA (including p53 gene), RNA, and lipids, and activate inflammatory, angiogenic, and extracellular matrix (ECM) remodeling proteins; which collectively facilitate carcinogenesis. The 1α,25-dihydroxyvitamin D3 (Vitamin D) has anti-carcinogenic potential from its antioxidant, anti-inflammatory, and endocrine properties. We examined the anti-carcinogenic mechanism of vitamin D through the beneficial regulation of oxidative stress effects (oxidative DNA/RNA damage, superoxide dismutase expression, membrane damage, and p53 promoter activity), and expression (at the protein, mRNA and/or promoter levels) of inflammatory mediators (interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α)), angiogenic mediators (transforming growth factor-β (TGF-β), and vascular endothelial growth factor (VEGF)), and the ECM remodeling proteins (matrix metalloproteinases (MMP)-1 and MMP-2) by vitamin D in melanoma cells. Vitamin D inhibited oxidative DNA/RNA damage and membrane damage; and stimulated superoxide dismutase expression and p53 promoter activity in melanoma cells. It inhibited the expression of IL-1, TNF-α, TGF-β, VEGF, MMP-1 and MMP-2 by transcriptional or post-transcriptional mechanisms. We conclude that vitamin D is beneficial to melanoma cells through the inhibition of oxidative DNA/RNA damage, membrane damage, and the expression of inflammatory, angiogenic and ECM remodeling proteins; and the stimulation of superoxide dismutase expression and p53 promoter activity.

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“…Likewise, related to food allergens, we found a statistically significant positive correlation between vitDs level and tIgE, and sIgE ≥ 3 class on hen's egg yolk and hen's egg white (p = 0.006), which we consider to be interdependence. Several studies investigated the relationship between vitamin D deficiency and allergic diseases and concluded that low level of vitamin D is associated with increased incidence of allergies and asthma [16,17,18]. Poole et al [19] in their study conducted on infants showed that vitamin D insufficiency is associated with an increased risk of a challenge-proven peanut/egg allergy.…”

Section: Discussionmentioning

confidence: 99%

Dependence of the allergic status markers on the level of vitamin D in the serum

Dajic

Stojkovic²,

Novkovic

et al. 2019

Srp Arh Celok Lek

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Introduction/Objective Recent researches show a link between low vitamin D serum levels and increased prevalence of allergic disease. The objective of this study was to show whether there is any dependence of the allergic status markers: skin prick test (SPT), total immunoglobulin E IgE (tIgE), and allergen-specific IgE (sIgE ≥ 3 class) in serum from the serum 25(OH)D (vitDs) level in children with allergic disease/s. Methods A total of 150 children with allergic disease/s were enrolled into this study. The vitDs, tIgE, SPT, and sIgE ≥ 3 class for aeroallergens and common food allergens were simultaneously assessed. Results We found a negative correlation between vitDs level and age groups and a statistically significant positive correlation between vitDs level and tIgE, sIgE ≥ 3 class for hen's egg yolk and hen's egg white. A statistically significant positive correlation was determined between vitDs level and SPT on Dermatophagoides pteronyssinus, and a negative correlation between tIgE and SPT on Dermatophagoides pteronyssinus, as well as between vitDs level and sIgE ≥ 3 class for Cladosporium and Alternaria molds. We confirmed the dependence of nettle rash and comorbidity asthma from the vitamin D insufficiency and vitamin D deficiency. We did not find any dependence of serum tIgE on vitDs level for the sample. Conclusion In order to get an adequate insight into the allergic status in children, we must take into account the pleotropic effects of vitamin D, according to which we suggest that, in the future, vitDs level should be determined synchronously with known markers of allergic status.

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Association of vitamin�D receptor expression with inflammatory changes and prognosis of asthma

Cited by 10 publications

References 21 publications

Evaluation of IGF-1, TNF-α, and TGF-β Gene Expression after Oral Vitamin D Supplementation in School-Aged Children with Chronic Bronchial Asthma

Evaluation of IGF-1, TNF-α, and TGF-β Gene Expression after Oral Vitamin D Supplementation in School-Aged Children with Chronic Bronchial Asthma

Beneficial Regulation of Cellular Oxidative Stress Effects, and Expression of Inflammatory, Angiogenic, and the Extracellular Matrix Remodeling Proteins by 1α,25-Dihydroxyvitamin D3 in a Melanoma Cell Line

Dependence of the allergic status markers on the level of vitamin D in the serum

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