Association of Vitamin D Receptor and Estrogen Receptor Gene Polymorphisms with Bone Mass in Korean Postmenopausal Women

Association between low bone mass and aortic valve sclerosis in Koreans

“…Oestrogen deficiency is a potential candidate that may explain these relationships, as oestrogen is a well-known factor involved in the pathophysiology of both osteoporosis and cardiovascular disease in women. Furthermore, oestrogen receptor polymorphism, which was shown to be associated with low bone mass in several clinical studies, [21][22][23] was also reported to be related to aortic valve sclerosis in postmenopausal women. 24 This suggests the involvement of genetic factors as well as oestrogenic effects in this relationship.…”

Vitamin D receptor gene polymorphisms in a group of postmenopausal Turkish women: association wıth bone mineral density

“…Up to 50% of the variance in BMD has been attributed to genetic factors. However, the results of the association analyses are incompatible 14,[23][24][25] . Polymorphisms at both the 3 0 end of the VDR gene and at the start codon were extensively studied in various populations in order to establish an association with BMD 5,26 .…”

Association of Polymorphisms of the Estrogen Receptor α Gene With Bone Mineral Density and Fracture Risk in Women: A Meta-Analysis

“…Because estrogens have important effects on bone mass and bone remodeling, (4, 5) many investigators have evaluated the role of estrogen receptor gene polymorphisms in the genetic regulation of BMD. Most studies have targeted polymorphisms of the estrogen receptor α gene, in particular those defined by the restriction enzymes Xba I and Pvu II (6–27) . Alleles are denoted by x and p or X and P , depending on whether the restriction site is recognized or not.…”