Association of vitamin D receptor polymorphisms with colorectal cancer susceptibility: A systematic meta-analysis

Abstract

Background: Recent studies have reported an association between vitamin D receptor (VDR) polymorphisms and colorectal cancer (CRC) risk; however, the results are controversial. This meta-analysis was performed to investigate whether the Cdx-2, Tru9I, FokI, BsmI, TaqI, and ApaI polymorphisms were correlated with CRC susceptibility.Methods: All potential studies were retrieved by searching the PubMed, EMBASE, and Cochrane Library databases through October 2, 2021. Odds ratios (ORs) with 95% confidence intervals were used to evaluate the correlation between VDR gene Cdx-2, Tru9I, FokI, BsmI, TaqI, and ApaI polymorphisms and CRC risk.Results: In this meta-analysis, the BsmI variant was significantly correlated with a lower risk of CRC, especially in Caucasian population

Is vitamin D receptor (VDR) polymorphism associated with head and neck cancer risk? A systematic review and meta‐analysis

“…The role of BsmI polymorphism in cancer predisposition potentially varies depending on the cancer type. In particular, it was significantly associated with a lower risk of colorectal cancer in the Caucasian population, 42 whereas it significantly increases the risk of basal cell carcinomas in males 43 …”

“…The BsmI, located in the 3 0 untranslated region (UTR) of the VDR gene, is intronic but likely influences gene expression regulation and mRNA stability. 41,42 The role of BsmI polymorphism in cancer predisposition potentially varies depending on the cancer type. In particular, it was significantly associated with a lower risk of colorectal cancer in the Caucasian population, 42 whereas it significantly increases the risk of basal cell carcinomas in males.…”

“…41,42 The role of BsmI polymorphism in cancer predisposition potentially varies depending on the cancer type. In particular, it was significantly associated with a lower risk of colorectal cancer in the Caucasian population, 42 whereas it significantly increases the risk of basal cell carcinomas in males. 43 Similar to TaqI and BsmI, the ApaI polymorphism is located near the 3 0 UTR of the VDR gene and does not alter the amino acid sequence of the protein.…”

“…Regarding the analysis on BsmI, the Bb and bb alleles were associated with a higher (OR = 1.88, 95% CI 1.11–3.19, p = 0.02) and lower (OR = 0.59, 95% CI 0.35–0.99, p = 0.05) risks of oral cancer, respectively. The BsmI, located in the 3′ untranslated region (UTR) of the VDR gene, is intronic but likely influences gene expression regulation and mRNA stability 41,42 . The role of BsmI polymorphism in cancer predisposition potentially varies depending on the cancer type.…”