Association of vitamin D deficiency with cognitive impairment in older women

Annweiler, Cédric; Schott, Anne-Marie; Allali, Gilles; Bridenbaugh, Stephanie A.; Kressig, Reto W.; Allain, Philippe; Herrmann, Françoís; Beauchet, Olivier

doi:10.1212/wnl.0b013e3181beecd3

Cited by 176 publications

(142 citation statements)

References 21 publications

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“…(8,9,30,31) For example, vitamin D status has been associated with cognitive function such as attention, which is involved in gait control in older adults. (32)(33)(34)(35)(36) Fast-pace walking is precisely considered as a more attention-demanding task than usual-pace walking, (23,36) which could explain in part the close positive association shown in our study.…”

Section: Discussionsupporting

confidence: 58%

Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: The EPIDOS study

Annweiler

Schott

Montero‐Odasso

et al. 2010

Journal of Bone and Mineral Research

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The purpose of this study was to determine whether there was an association between serum 25-hydroxyvitamin D [25(OH)D] concentration and walking speed measured at usual and fast pace among older women. Usual-and fast-pace walking speeds and 25(OH)D concentrations were assessed in 739 randomized older women (mean age 80.2 AE 3.5 years) from the EPIDOS study. The following 25(OH)D thresholds were used: 10, 20, and 30 ng/mL. Walking speed was dichotomized on being in the worst quintile or not. Age, body mass index, number of chronic diseases, physical activity, quadriceps strength, cognition, use of psychoactive drugs, and serum parathyroid hormone were used as potential confounders. The results show that 90% of subjects had 25(OH)D insufficiency. Only fast-pace walking speed was significantly different between groups ( p ¼ .

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Section: Discussionsupporting

confidence: 58%

Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: The EPIDOS study

Annweiler

Schott

Montero‐Odasso

et al. 2010

Journal of Bone and Mineral Research

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“…In addition to animal findings, recent human studies reported low levels of the plasma 25-dihydroxyvitamin D 3 (25OHD) for individuals suffering mood disorders, PD, AD or cognitive decline (Wilkins et al 2006;Cherniack et al 2008;Evatt et al 2008;McCann and Ames 2008;Llewellyn et al 2009;Annweiler et al 2010;Llewellyn et al 2010). Another study showed significantly higher Mini-Mental State Examination (MMSE) scores for vitamin-D-sufficient patients compared to vitamin-D insufficient ones (Oudshoorn et al 2008).…”

Section: Discussionmentioning

confidence: 96%

Vitamin D Receptor Gene Haplotype Is Associated with Late-Onset Alzheimer's Disease

Gezen-Ak

Dursun

Bılgıç

et al. 2012

Tohoku J. Exp. Med.

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Vitamin D 3 is a neurosteroid that mediates its effects via the vitamin D receptor (VDR). The VDR gene is located on chromosome 12q13 and consists of 9 exons. VDR contains the DNA-binding site encoded by exons 2 and 3 and the ligand-binding site encoded by exons 4 -9. Our earlier study showed that the ApaI polymorphic site of the VDR gene is associated with late-onset Alzheimer's disease (AD). Here, we investigated the association between additional polymorphisms of the VDR gene and AD using the same samples. Two single nucleotide polymorphisms (SNPs) in intron 8 (BsmI and Tru9I polymorphisms) and one in exon 2 (FokI polymorphism) of the VDR gene were examined in up to 108 AD patients and 115 age-matched controls. Genotypes were determined with polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. Haplotype analysis also included the previously studied polymorphic sites that were recognized by TaqI (in exon 9) and ApaI (in intron 8) restriction enzymes. There was no significant difference between AD patients and controls when their genotypes for BsmI, Tru9I and FokI polymorphic sites were compared. However, the frequency of "TaubF" haplotype (alleles of TaqI, ApaI, Tru9I, BsmI and FokI, respectively), which was determined by analyzing 5 polymorphisms together, was significantly higher in the AD patient group, suggesting that this haplotype is a risk factor in AD. Our results point out a possible link between AD and certain VDR polymorphisms and indicate that individuals with these polymorphisms might be vulnerable to AD.

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“…However, Slinin et al (2010) recently reported that they found little evidence of independent associations between lower 25(OH)D level and baseline global and executive function, or indeed, cognitive decline in a cohort of 1603 men aged X65 years. A recent cross-sectional study carried out in an all-female cohort (n ¼ 752; aged 75 þ years) reported that communitydwelling women with low serum 25(OH)D concentrations (p25 nmol/l) had significantly poorer scores in the Pfeiffer Short Portable Mental State Questionnaire (a screening tool for dementia) compared with women with concentrations of 425 nmol/l (Annweiler et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D status and measures of cognitive function in healthy older European adults

et al. 2010

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Background/Objectives: Data from human studies that have investigated the association between vitamin D status and cognitive function in elderly adults are conflicting. The objective of this study was to assess vitamin D status (reflected by serum 25-hydroxyvitamin D (25(OH)D)) in older European subjects (n ¼ 387; aged 55-87 years) and examine its association with measures of cognitive function. Subjects/Methods: Serum 25(OH)D was assessed using enzyme-linked immunosorbent assay, whereas measures of cognitive function were assessed using a comprehensive Cambridge Neuropsychological Testing Automated Battery (CANTAB). Results: In all, 12, 36 and 64% of subjects had serum 25(OH)D concentrations o30, o50 and o80 nmol/l, respectively, throughout the year. Serum 25(OH)D was significantly and inversely correlated with four assessments within the spatial working memory (SWM) test parameter (SWM between errors (r ¼ À0.166; P ¼ 0.003); SWM between errors 8 boxes (r ¼ À0.134; P ¼ 0.038); SWM strategy (r ¼ À0.246; Po0.0001); and SWM total errors (r ¼ À0.174; Po0.003)). When subjects were stratified on the basis of tertiles (T) of serum 25(OH)D (o47.6 (T 1 ); 47.6-85.8 (T 2 ); and 485.8 (T 3 ) nmol/l), fewer errors in SWM test scores occurred in subjects in the third T when compared with the first T (Po0.05-0.084). Stratification by sex showed that these differences between tertiles strengthened (Po0.001-0.043) in the females, but the differences were not significant (P40.6) in males. Conclusions: Vitamin D insufficiency, but not deficiency, is widespread in the older population of several European countries. Low vitamin D status was associated with a reduced capacity for SWM, particularly in women.

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Association of vitamin D deficiency with cognitive impairment in older women

Abstract: 25-Hydroxyvitamin D deficiency was associated with cognitive impairment in this cohort of community-dwelling older women.

Cited by 176 publications

References 21 publications

Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: The EPIDOS study

Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: The EPIDOS study

Vitamin D Receptor Gene Haplotype Is Associated with Late-Onset Alzheimer's Disease

Vitamin D status and measures of cognitive function in healthy older European adults

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