Association of vitamin B6, vitamin B12 and methionine with risk of breast cancer: a dose–response meta-analysis

Wu, Wenlong; Kang, Shan; Zhang, D

doi:10.1038/bjc.2013.438

Cited by 81 publications

(65 citation statements)

References 54 publications

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“…When the lowest category was open-ended, the lowest boundary was set to zero. 22,23 All statistical analyses were conducted using STATA software (version 12.0; StatCorp., College Station, TX, USA) and p < 0.05 was considered as statistically significant.…”

Section: Resultsmentioning

confidence: 99%

Association between dietary vitamin C intake and risk of esophageal cancer: A dose–response meta‐analysis

Lü²,

Zhao

et al. 2015

Intl Journal of Cancer

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While several epidemiological studies have investigated the association between vitamin C and risk of esophageal cancer, the results remain inconsistent. In the present study, a meta-analysis was conducted to assess the impact of dietary vitamin C intake on esophageal cancer risk. Online databases were searched up to March 29, 2015, for studies on the association between dietary vitamin C intake and esophageal cancer risk. Pooled risk ratios (RRs) or odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model. Dose-response analyses were performed using the method of restricted cubic splines with four knots at percentiles of 5, 35, 65 and 95% of the distribution. Publication bias was estimated using Egger's tests and funnel plots. In all, 15 articles were included in this meta-analysis, including 20 studies, containing 7063 controls and 3955 cases of esophageal cancer. By comparing the highest vs. the lowest categories of vitamin C intake, we found that vitamin C was inversely associated with the risk of esophageal cancer [overall OR 5 0.58, 95% CI 5 0.49-0.68, I 2 5 56%]. A linear dose-response relationship was found. With an increase in dietary vitamin C intake of 50 mg/day, the risk of esophageal cancer statistically decreased by 13% (OR 5 0.87, 95% CI 5 0.80-0.93, p linearity 5 0.0002). In conclusion, our analysis suggested that the higher intake of dietary vitamin C might have a protective effect against esophageal cancer.Esophageal cancer ranks the tenth most common malignancy and the eighth leading cause of cancer-related deaths worldwide. 1 In 2012, [mt]456,000 newly diagnosed cases and 400,000 related deaths were reported. 2 Most esophageal cancer patients are diagnosed at the advanced stages, and the 5-year survival rate is <20%. 3 Thus, primary prevention of esophageal cancer is becoming critical.A large proportion of cases are induced by the action of chemical carcinogens. The epidemiological evidence suggests that alcohol consumption, smoking tobacco, N-nitroso compound and micronutrient deficiency are among the major risk factors for esophageal cancer. [4][5][6] The ultimate reactive and carcinogenic forms of most chemical carcinogens are strong electrophiles. 7 However, vitamin C can prevent carcinogenesis of esophageal cells by blocking the formation of Nnitroso compounds. [8][9][10][11][12] Since the first study that explored the association between vitamin C and esophageal cancer in 1987, 13 a number of epidemiological studies have investigated the relationship between vitamin C intake and esophageal cancer risk. However, these results are controversial. Therefore, we conducted a meta-analysis to assess the association of dietary vitamin C intake and the risk of esophageal cancer, and to evaluate the dose-response relationship of esophageal cancer and vitamin C intake. Material and Methods Search strategyA comprehensive literature search of Pubmed, and Web of Knowledge was conducted before March 2015. The following keywords were used: "esophageal cancer" or...

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Section: Resultsmentioning

confidence: 99%

Association between dietary vitamin C intake and risk of esophageal cancer: A dose–response meta‐analysis

Lü²,

Zhao

et al. 2015

Intl Journal of Cancer

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“…When the highest category was open-ended, we assumed the width of the category to be the same as that of the adjacent category. When the lowest category was open-ended, we set the lower boundary to zero2324. The dose-response results in forest plots are presented for every 100 mg/day increment in vitamin C intake.…”

Section: Methodsmentioning

confidence: 99%

Association between vitamin C intake and lung cancer: a dose-response meta-analysis

Luo

Shen

Zheng

2014

Sci Rep

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Epidemiological studies evaluating the association between the intake of vitamin C and lung cancer risk have produced inconsistent results. We conducted a meta-analysis to assess the association between them. Pertinent studies were identified by a search of PubMed, Web of Knowledge and Wan Fang Med Online through December of 2013. Random-effect model was used to combine the data for analysis. Publication bias was estimated using Begg's funnel plot and Egger's regression asymmetry test. Eighteen articles reporting 21 studies involving 8938 lung cancer cases were included in this meta-analysis. Pooled results suggested that highest vitamin C intake level versus lowest level was significantly associated with the risk of lung cancer [summary relative risk (RR) = 0.829, 95%CI = 0.734–0.937, I2 = 57.8%], especially in the United States and in prospective studies. A linear dose-response relationship was found, with the risk of lung cancer decreasing by 7% for every 100 mg/day increase in the intake of vitamin C [summary RR = 0.93, 95%CI = 0.88–0.98]. No publication bias was found. Our analysis suggested that the higher intake of vitamin C might have a protective effect against lung cancer, especially in the United States, although this conclusion needs to be confirmed.

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“…Besides, vitamin B 6 intake and blood PLP levels have been inversely associated with the risk of colorectal and breast cancer (Larsson et al 2010;Wu et al 2013). The design and methodology of these kinds of studies have raised a number of controversies: lack of good biological rationale for selecting specific agents of interest; limited number of agents tested; use of pharmacological, rather than dietary, doses; and insufficient duration of intervention and follow-up (Goodman et al 2011;Bast and Haenen 2013).…”

Section: Functions Of Plant Amino Acid-based Vitamins In Humansmentioning

confidence: 99%

Plant amino acid-derived vitamins: biosynthesis and function

Miret

Munné‐Bosch

2013

Amino Acids

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Vitamins are essential organic compounds for humans, having lost the ability to de novo synthesize them. Hence, they represent dietary requirements, which are covered by plants as the main dietary source of most vitamins (through food or livestock's feed). Most vitamins synthesized by plants present amino acids as precursors (B1, B2, B3, B5, B7, B9 and E) and are therefore linked to plant nitrogen metabolism. Amino acids play different roles in their biosynthesis and metabolism, either incorporated into the backbone of the vitamin or as amino, sulfur or one-carbon group donors. There is a high natural variation in vitamin contents in crops and its exploitation through breeding, metabolic engineering and agronomic practices can enhance their nutritional quality. While the underlying biochemical roles of vitamins as cosubstrates or cofactors are usually common for most eukaryotes, the impact of vitamins B and E in metabolism and physiology can be quite different on plants and animals. Here, we first aim at giving an overview of the biosynthesis of amino acid-derived vitamins in plants, with a particular focus on how this knowledge can be exploited to increase vitamin contents in crops. Second, we will focus on the functions of these vitamins in both plants and animals (and humans in particular), to unravel common and specific roles for vitamins in evolutionary distant organisms, in which these amino acid-derived vitamins play, however, an essential role.

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Association of vitamin B6, vitamin B12 and methionine with risk of breast cancer: a dose–response meta-analysis

Cited by 81 publications

References 54 publications

Association between dietary vitamin C intake and risk of esophageal cancer: A dose–response meta‐analysis

Association between dietary vitamin C intake and risk of esophageal cancer: A dose–response meta‐analysis

Association between vitamin C intake and lung cancer: a dose-response meta-analysis

Plant amino acid-derived vitamins: biosynthesis and function

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