Association of Visceral and Subcutaneous Fat Mass With Bone Density and Vertebral Fractures in Women With Severe Obesity

Crivelli, Marise; Chain, Amina; Silva, Igor T.F. da; Waked, Amin M.; Bezerra, Flávia Fioruci

doi:10.1016/j.jocd.2020.10.005

Cited by 17 publications

(9 citation statements)

References 30 publications

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“…Our results are consistent with a study of older Chinese women ( 32 ). However, the results are different from studies of obese adolescent girls ( 30 , 33 ). This difference is probably because the population age in our study was much older than that in the studies of young girls, and the estrogen level of the population in our study was much lower than that in young girls.…”

Section: Discussioncontrasting

confidence: 96%

“…Researchers have speculated that this protective effect may be due to the stimulation of bone formation by the high mechanical load associated with overweight and obesity ( 11 ). However, a recent study showed that different local fat compartments are responsible for different metabolic effects and different effects on bone ( 30 , 31 ). Wang et al.…”

Section: Discussionmentioning

confidence: 99%

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Quantification of lumbar vertebral fat deposition: Correlation with menopausal status, non-alcoholic fatty liver disease and subcutaneous adipose tissue

et al. 2023

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PurposeTo assess abdominal fat deposition and lumbar vertebra with iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL-IQ) and investigate their correlation with menopausal status.Materials and MethodsTwo hundred forty women who underwent routine abdominal MRI and IDEAL-IQ between January 2016 and April 2021 were divided into two cohorts (first cohort: 120 pre- or postmenopausal women with severe fatty livers or without fatty livers; second cohort: 120 pre- or postmenopausal women who were obese or normal weight). The fat fraction (FF) values of the liver (FFliver) and lumbar vertebra (FFlumbar) in the first group and the FF values of subcutaneous adipose tissue (SAT) (FFSAT) and FFlumbar in the second group were measured and compared using IDEAL-IQ.ResultsTwo hundred forty women were evaluated. FFlumbar was significantly higher in both pre- and postmenopausal women with severe fatty liver than in patients without fatty livers (premenopausal women: p < 0.001, postmenopausal women: p < 0.001). No significant difference in the FFlumbar was observed between obese patients and normal-weight patients among pre- and postmenopausal women (premenopausal women: p = 0.113, postmenopausal women: p = 0.092). Significantly greater lumbar fat deposition was observed in postmenopausal women than in premenopausal women with or without fatty liver and obesity (p < 0.001 for each group). A high correlation was detected between FFliver and FFlumbar in women with severe fatty liver (premenopausal women: r=0.76, p<0.01; postmenopausal women: r=0.82, p<0.01).ConclusionFat deposition in the vertebral marrow was significantly associated with liver fat deposition in postmenopausal women.

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Section: Discussioncontrasting

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Quantification of lumbar vertebral fat deposition: Correlation with menopausal status, non-alcoholic fatty liver disease and subcutaneous adipose tissue

et al. 2023

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“…Sun et al (2020) showed that BMD was positively correlated with BMI at 18.0–31.2 kg/m 2 and BMI from 31.3–40.6 kg/m 2 was negatively associated. This is generally in line with the conclusion suggested by Crivelli et al (2021) as it was indicated that a BMI of ≥40 kg/m 2 increases the risk of lumbar fractures. The dual effect of BMI on BMD may be due to multiple mechanisms such as weight, bone formation, and the bone marrow microenvironment ( Sun et al, 2020 ).…”

Section: Discussionsupporting

confidence: 92%

Association between androgen receptor gene alteration and osteoporosis in Chinese Han elderly men

Huang

Zhang

Zou

et al. 2023

PeerJ

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Objective To explore the role of blood glucose, blood lipids, and androgen receptor gene (CAG)n genotype in the pathogenesis of osteoporosis in Chinese Han men and to provide theoretical value for screening people susceptible to osteoporosis. Methods Patients who visited the First Affiliated Hospital of Chengdu Medical College from February 2021 to October 2021 were selected as research subjects to measure bone density by double-energy X-ray, osteoporosis patients as osteoporosis group (40 patients), and non-osteoporosis patients as the control group (40 patients). The STR method detected the repeat times of the androgen receptor gene (CAG)n in the two groups. The repeat times ≤22 were the SS genotype, and >22 were the LL genotype. Meanwhile, the patient’s age, body mass index (BMI), blood glucose, blood lipids, calcium, phosphorus, and alkaline phosphatase examined on day one after admission were collected, and the statistical analysis was performed using SPSS 26.0. Results The results of the univariate analysis showed that there was no significant difference in age, calcium, phosphorus, alkaline phosphatase, and glycosylated hemoglobin between the two groups (P > 0.05). There were significant differences in average blood glucose, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, and genotype frequency (P < 0.05). The multivariate logistic regression analysis results showed significant differences in total cholesterol and genotype frequency between the two groups (P < 0.05). Conclusion Androgen receptor LL genotype and elevated total cholesterol may be the risk factors for osteoporosis in older men of Han nationality.

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“…However, femur BMD decreased relative to body weight in higher BMI categories possibly due to smaller fraction of the lean mass in obesity. The authors did not found variations of upper extremity fractures associated with BMI [19]. Increased body fat mass index has been associated with spinal fractures in women that has been suggested to be related to metabolically active abdominal adipose tissue [11].…”

Section: Association Between Bmi and Bmdmentioning

confidence: 76%

Association between body composition and bone mineral density assessed by whole body dual-energy X-ray absorptiometry

Nikolov¹,

Lambova²,

Nikolov³

2022

RBJ

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Introduction: Despite the observation that higher body weight has protective effect against the development of osteoporosis, accumulating evidence suggest presence of negative impact of obesity on bone function associated with the low-grade inflammation and production of proinflammatory cytokines from dysfunctional adipose tissue in obese individuals. These data stimulate the interest and suggest need for clarifying studies about the association between the body composition and bone mineral density. The aim of the study: The aim of the current study was to evaluate the association between body mass index (BMI), body composition (fat mass and lean body mass) and the bone mineral density of the lumbar spine and femoral neck assessed by whole body scan using DXA (dual-energy x-ray absorptiometry). Materials and methods: A retrospective study was performed with analysis of patient data who have undergone whole body scan in Medical Center “Avis Medica” Pleven, device Lunar prodigy. The values of T-score of the lumbar spine and femoral neck were analyzed and their associations with body composition and BMI. Results and discussion: 111 women at mean age 59±8 years were included in the study. In the patients with T-score values ≤ /-2.5/ of the lumbar spine and femoral neck BMI was significantly lower. In the group of patients with T-score values of the lumbar spine ≤ /-2.5/ (n=27), significantly lower fat mass was found (2239.90±607.63 grams) in comparison with the cases with T-score > /-2.5/ (n=84) (fat mass 2510.41±570.68 grams; p=0.037). The lean body mass in the patients with T-score ≤ /-2.5/ of the lumbar spine (4025.30±862.58 grams) was also significantly lower vs the group with T-score > /-2.5/ (4760.09±607.63 grams; p=0.000). A significant difference of body lean mass was also found between the groups with different T-score of femoral neck (4110.60±832.01 grams in patients with T-score of femoral neck ≤2.5, n=15; 4802.01±862.87 grams in those with T-score>2.5, n=96, p=0.004). Regarding the fat mass and fat percentage in the groups with different T-score of the femoral neck, they were lower in the patients with osteoporosis with T-score < /-2.5/, but the difference reached statistical significance only for the fat percentage (31 vs 38%, p=006) but not for the fat mass (p=0.081). Conclusion: The results of the current study confirm the protective effect of the higher lean and fat mass against the development of osteoporosis with possible leading role of the lean mass.

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Association of Visceral and Subcutaneous Fat Mass With Bone Density and Vertebral Fractures in Women With Severe Obesity

Cited by 17 publications

References 30 publications

Quantification of lumbar vertebral fat deposition: Correlation with menopausal status, non-alcoholic fatty liver disease and subcutaneous adipose tissue

Quantification of lumbar vertebral fat deposition: Correlation with menopausal status, non-alcoholic fatty liver disease and subcutaneous adipose tissue

Association between androgen receptor gene alteration and osteoporosis in Chinese Han elderly men

Association between body composition and bone mineral density assessed by whole body dual-energy X-ray absorptiometry

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