Association of vaspin rs2236242 gene variants and circulating serum vaspin concentrations with coronary artery disease in a Turkish population

Abstract

Coronary artery disease (CAD) is the primary cause of death worldwide. Vaspin was a recently described adipokine, playing a protective role in many metabolic and cardiovascular diseases. This study aimed to assess the relation of serum vaspin levels and vaspin rs2236242 polymorphisms with CAD. The study included 105 healthy subjects and 105 CAD patients. Serum vaspin concentrations and vaspin rs2236242 polymorphisms were determined by enzyme‐linked immunosorbent assay and polymerase chain reaction, respectively. There was a statistically significant difference between the genotypes of CAD patients (TT 26.7%, TA 71.4%, and AA 1.9%) and controls (TT 70.5%, TA 28.6%, and AA 1%; χ2 = 40.3; df = 2; p = .000). The TA genotype increased the risk of CAD (odds ratio [OR] = 6.60; 95% confidence interval [CI] = 3.60–12.1; p = .000) as compared to the TT genotype. There was a statistically significant difference between the allelic distribution of CAD patients (T 62.4% and A 37.6%) and controls (T 84.8% and A 15.2%; χ2 = 27.0; df = 1; p = .000). Those carrying the A allele had a higher risk of CAD compared to those with the T allele (OR = 3.35; 95% CI = 2.10–5.36; p = .000). The serum vaspin concentrations of the patients with TT, TA, and AA genotypes were 30.4 ± 1.72, 28.4 ± 2.89, and 36.4 ± 6.38 pg/ml, respectively, and there was no significant difference between the serum vaspin levels and vaspin genotypes (p = .696). All of the above suggested that the vaspin rs2236242 polymorphism was associated with CAD in the Turkish population.

The The relationship between NLRP3 rs10159239 and Vaspin rs2236242 gene variants and obstructive sleep apnea

“…In another study on its association with coronary artery disease, there was a significant correlation between the AT genotype and coronary artery disease, while the TT genotype was more frequent in controls. When compared in terms of plasma vaspin levels, the TT genotype had relatively higher vaspin levels than the AT genotype, but as there were only three patients with the AA genotype, the analysis was weak ( 14 ).…”

“…Studies of vaspin rs2236242 (rs6242) single nucleotide polymorphism (SNP) demonstrated that individuals carrying the A allele had higher risk of developing type 2 diabetes mellitus ( 13 ). In another recent study, patients with the vaspin A allele were also found to be at higher risk of developing coronary artery disease ( 14 ). However, the serum vaspin level was not associated with genotype frequency in either of these studies.…”

The Efficacy of Ezetimibe Combined with Simvastatin in Patients with Coronary Heart Disease and Its Effect on Serum Retinol Binding Protein 4, Thioredoxin Interaction Protein and Visceral Adipose Tissue Serine Protease Inhibitor

“…This also suggests that ezetimibe not only has lipid lowering effects, but also may have protective effects on vascular endothelial cells and myocardium and in addition, it may improve endothelial function and reduce cardiomyocytes apoptosis, thereby controlling the atherosclerotic process in patients with CHD. Vaspin is one of the highly expressed adipocytokines in visceral fat, whose levels are inversely related to the risk of atherosclerosis, hypertension and stroke, and their levels can also be used to reflect the degree of lipid lowering effect [17] .…”