Association of vasomotor symptoms and sleep apnea risk in midlife women

Gao, Catherine C.; Kapoor, Ekta; Lipford, Melissa C.; Miller, Virginia M.; Schroeder, Darrell R.; Mara, Kristin C.; Faubion, Stephanie S.

doi:10.1097/gme.0000000000001020

Cited by 16 publications

(12 citation statements)

References 56 publications

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“…Therefore, the onset, frequency, intensity and duration of the symptoms may represent differences in underlying dysfunction in central and autonomic mechanisms and may involve other brain regions associated with sleep and mood. [84] Indeed, severe vasomotor symptoms may be related to obstructive sleep apnea [85], which is a risk factor for coronary artery calcification. [86]…”

Section: Autonomic Neurovascular Dysregulationmentioning

confidence: 99%

Sex-Specific Physiology and Cardiovascular Disease

Shufelt

Pacheco

et al. 2018

Advances in Experimental Medicine and Biology

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103

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Sex differences in cardiovascular diseases can be classified as those which are specific to one sex and those that differ in incidence, prevalence, etiology, symptomatology, response to treatment, morbidity, and mortality in one sex compared to the other. All sex differences in cardiovascular conditions have their basis in the combined expression of genetic and hormonal differences between women and men. This chapter addresses how understanding basic mechanisms of hormone responses, imaging diagnostics, and integration of genomics and proteomics has advanced diagnosis and improved outcomes for cardiovascular conditions, apart from those related to pregnancy that are more prevalent in women. These conditions include obstructive coronary artery disease, coronary microvascular dysfunction, spontaneous coronary artery dissection, diseases of the cardiac muscle including heart failure and takotsubo cardiomyopathy, and conditions related to neurovascular dysregulation including hot flashes and night sweats associated with menopause and effects of exogenous hormones on vascular function. Improvement in technologies allowing for noninvasive assessment of neuronally mediated vascular reactivity will further improve our understanding of the basic etiology of the neurovascular disorders. Consideration of sex, hormonal status, and pregnancy history in diagnosis and treatment protocols will improve prevention and outcomes of cardiovascular disease in women as they age.

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Section: Autonomic Neurovascular Dysregulationmentioning

confidence: 99%

Sex-Specific Physiology and Cardiovascular Disease

Shufelt

Pacheco

et al. 2018

Advances in Experimental Medicine and Biology

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103

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“…Women with severe vasomotor patterns may need to undergo additional testing for sleep disorders such as obstructive sleep apnea or restless leg syndrome, particularly if the vasomotor symptom but not the sleep disturbances are diminished by MHT. (21-23) In general, the severity of vasomotor symptoms is also associated with an increased risk of cardiovascular disease including endothelial dysfunction, development of carotid intima media thickness, coronary artery calcification, cardiac microvascular disease, and adverse cardiac events. (24-27) However, the risk may vary with both the age of onset of menopause and the severity and type of the vasomotor disturbance (daytime hot flashes, night sweats or both.…”

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confidence: 99%

What's in a name: are menopausal “hot flashes” a symptom of menopause or a manifestation of neurovascular dysregulation?

et al. 2018

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Hot flashes have typically been classified as "symptoms of menopause" that should be tolerated or treated until they resolve. However, mounting evidence points to hot flashes as a manifestation of one or several underlying pathophysiological processes. Associations exist between the presence, timing of onset, severity, and duration of hot flashes, and the risk of several neurological (affecting sleep, mood, and cognition) and cardiovascular conditions. In addition, four consistent patterns of vasomotor disturbances have been identified across different countries, making it unlikely that these patterns are solely explained by socioeconomic or cultural factors. The changing hormonal environment of menopause may unmask differences in the autonomic neurovascular control mechanisms that put an individual woman at risk for chronic conditions of aging. These differences may have a genetic basis or may be acquired across the life span and are consistent with the variability of the clinical manifestations of aging observed in women after bilateral oophorectomy. It is time to investigate the pathophysiological mechanisms underlying the four patterns of vasomotor symptoms more closely, and to shift from describing hot flashes as symptoms to be tolerated to manifestations of an underlying autonomic neurovascular dysregulation that need to be addressed.

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“…При [17,26]. Показано, что наличие вазомоторных симптомов в постменопаузе в 1,85 раза увеличивает риск ночных пробуждений [20]. Выявлена взаимосвязь между частотой ночных «приливов» и количеством пробуждений во время сна [17].…”

Section: Biology and Medical Biologyunclassified

“…Однако исследования C.C. Gao et al показали, что вазомоторные симптомы также могут быть факторами риска для развития СОАС даже у женщин с индексом массы тела < 25 кг/м 2 [20].…”

Section: Biology and Medical Biologyunclassified

Sleep features in menopausal women (literature review)

Мадаева¹,

Semenova²,

Astafyev³

et al. 2018

ABS

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The article reviews the literature of domestic and foreign researchers devoted to the somnological aspects of the menopausal period in women. Age-related changes in the structural organization of sleep are shown with a deficiency of sex steroids, also and in the gender aspect. A high frequency of sleep disorders in menopausal women, reaching 60 %, has been revealed. However, the results of studies on complaints of sleep disorders depending on the climacteric phase are ambiguous, which may be due to ethnicity. Data on some pathogenetic mechanisms of the formation of the most frequent sleep disorders in menopausal women-insomnia, obstructive sleep apnea syndrome and fibromyalgia-are described. The results of polysomnography in these pathological states are presented, indicating a decrease in sleep efficiency, a change in its "architecture", and a longer waking time during the night with insomnia; a significant increase in the apnea/hypopnea index, a delay in the phase of fast sleep, a decrease in the duration of deep stages of sleep and a decrease in its effectiveness-in obstructive sleep apnea syndrome. The social and medical consequences of sleep disorders and their comorbidity with such pathological conditions as mental disorders, obesity, cardiovascular diseases, oncology, disorders of carbohydrate metabolism, bronchial asthma, mortality are noted.

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Association of vasomotor symptoms and sleep apnea risk in midlife women

Abstract: Self-reported severe/very severe VMS were associated with intermediate/high risk for OSA in midlife women, even in women with BMI <25 kg/m. Given the limitations of the STOP-BANG tool, OSA risk may, however, have been overestimated.

Cited by 16 publications

References 56 publications

Sex-Specific Physiology and Cardiovascular Disease

Sex-Specific Physiology and Cardiovascular Disease

What's in a name: are menopausal “hot flashes” a symptom of menopause or a manifestation of neurovascular dysregulation?

Sleep features in menopausal women (literature review)

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