Association of various risk factors with chronic lymphocytic leukemia and its cytogenetic characteristics

Karakosta, Maria; Delicha, Eumorfia-Maria; Kouraklis, Gregory; Manola, Kalliopi N.

doi:10.1080/19338244.2015.1116429

Cited by 25 publications

(25 citation statements)

References 61 publications

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“…Additionally, the inclusion of more studies allowed for the further investigation of exposure characteristics, including hair dye type and duration/time period of use. A methodological limitation was less accurate exposure classification in studies that assessed the risk of leukemia due to a suite of past occupational and lifestyle exposures, and therefore only collected limited data on the history of lifetime hair dye use . Specifically, studies that only collected information on “ever” use of hair dye were unable to adequately characterize exposure profiles that may influence the risk of disease, as shown in the above stratified analyses.…”

Section: Discussionmentioning

confidence: 99%

“…Since the meta‐analysis of Takkouche in 2005, ten studies have been published in which the association between personal hair dye use and the risk of one or more leukemia subtypes was evaluated . Many of these more recent studies provided more robust information on gender and hair dye use patterns, including hair dye type and time period/duration of use.…”

Section: Introductionmentioning

confidence: 99%

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Personal use of hair dyes and risk of leukemia: a systematic literature review and meta‐analysis

Towle

Grespin²,

Monnot

2017

Cancer Medicine

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The objective of this study was to examine the association between personal use of hair dyes and the risk of leukemia. We conducted a systematic literature review of epidemiology studies reporting leukemia‐specific cancer risks among hair dye users, and estimated the meta‐relative risk (meta‐RR) and corresponding 95% confidence interval (95% CI) of leukemia, comparing hair dye users to nonusers. When data from all 20 studies that met the inclusion criteria were combined, ever use of hair dye was associated with a nonstatistically significant increased risk of leukemia, meta‐RR = 1.09 (95% CI: 0.97–1.22). When restricted to studies that adjusted for smoking, ever use of hair dye was not associated with leukemia, meta‐RR = 0.99 (95% CI: 0.76–1.29). A statistically significant increased risk of leukemia was associated with permanent hair dye use (meta‐RR = 1.19 [95% CI: 1.07–1.33]), dark hair dye use (meta‐RR = 1.29 [95% CI: 1.11–1.50]), hair dye use among males (meta‐RR = 1.42 [95% CI: 1.01–2.00]), hair dye use pre‐1980 (meta‐RR = 1.49 [95% CI: 1.21–1.83]), and hair dye use for ≥15 years (meta‐RR = 1.35 [95% CI: 1.13–1.62]). Overall, findings suggest that ever use of hair dye is not a significant risk factor for leukemia. Certain hair dye use characteristics were associated with a statistically significant increased risk, but further research is required to determine whether these associations truly reflect a risk of leukemia due to methodological limitations in the underlying studies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Personal use of hair dyes and risk of leukemia: a systematic literature review and meta‐analysis

Towle

Grespin²,

Monnot

2017

Cancer Medicine

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“…Lachapelle (1986) Possick et al (1970) Sertoli et al (1992 Skotnicki-Grant (2008) Focus groupsInterviews with workers exposed to insulation materials that contain some mention of the role of larger diameter fibers. Adegoke et al, 2003: Brown et al, 1990Costantini et al, 2008;Deschler & L€ ubbert, 2006;Glass et al, 2003;IARC, 2012;Rinsky, 1989;Rodriguez-Abreu et al, 2007;Schwilk et al, 2010;Smith & Zhang, 1998;Zeeb & Blettner, 1998;Zhang et al, 2009Electromagnetic fields Floderus et al, 1993Karakosta et al, 2016;Rodriguez-Abreu et al, 2007Radiation Band et al, 1996Deschler & L€ ubbert, 2006;Greaves, 1997;Karakosta et al, 2016;Leuraud et al, 2015;Richardson et al, 2015;Rodriguez-Abreu et al, 2007;Smith & Zhang, 1998;Zeeb & Blettner, 1998Lifestyle-related Smoking Brownson et al, 1993Danaei et al, 2005;Fernberg et al, 2007;Fircanis et al, 2014;Kane et al, 1999;Karakosta et al, 2016;Smith & Zhang, 1998;Wang et al, 2015Obesity Calle et al, 2...…”

Section: Appendixmentioning

confidence: 99%

“…Matsuoka & Jeang, 2007;De Roos et al, 2013;Rodriguez-Abreu et al, 2007 Family history Family history of leukemia or any cancer. Karakosta et al, 2016;Rauscher et al, 2002 (a) Some reported associations are controversial, such as the relation between occupational exposure to formaldehyde and leukemia (Collins & Lineker, 2004;Heck and Casanova, 2004). (b) IARC (2012) concluded that there is limited human evidence for the carcinogenicity of ethylene oxide.…”

Section: Appendixmentioning

confidence: 99%

Review of refractory ceramic fiber (RCF) toxicity, epidemiology and occupational exposure

Maxim¹,

Utell

2018

Inhalation Toxicology

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This literature review on refractory ceramic fibers (RCF) summarizes relevant information on manufacturing, processing, applications, occupational exposure, toxicology and epidemiology studies. Rodent toxicology studies conducted in the 1980s showed that RCF caused fibrosis, lung cancer and mesothelioma. Interpretation of these studies was difficult for various reasons (e.g. overload in chronic inhalation bioassays), but spurred the development of a comprehensive product stewardship program under EPA and later OSHA oversight. Epidemiology studies (both morbidity and mortality) were undertaken to learn more about possible health effects resulting from occupational exposure. No chronic animal bioassay studies on RCF have been conducted since the 1980s. The results of the ongoing epidemiology studies confirm that occupational exposure to RCF is associated with the development of pleural plaques and minor decrements in lung function, but no interstitial fibrosis or incremental lung cancer. Evidence supporting a finding that urinary tumors are associated with RCF exposure remains, but is weaker. One reported, but unconfirmed, mesothelioma was found in an individual with prior occupational asbestos exposure. An elevated SMR for leukemia was found, but was absent in the highly exposed group and has not been observed in studies of other mineral fibers. The industry will continue the product stewardship program including the mortality study.

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“…39 ). CLL occurrence has also been connected with several occupational and environmental exposures 37,40 . Among first-degree relatives of CLL patients, there is an increased risk of the same malignancy or other lymphoproliferative diseases 37,[41][42][43][44] .…”

Section: Introductionmentioning

confidence: 99%

Profiling of biological and environmental risk factors in immunogenetic subgroups of chronic lymphocytic leukemia - Czech national study

Stránská¹,

Plevová²,

Francová³

et al. 2020

BIOMED PAP

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Aims. This is a nationwide survey of chronic lymphocytic leukemia (CLL) patients at six large hematology centers in the Czech Republic. The aim was to identify specific populations, social, and health characteristics of CLL subgroups divided according to the immunogenetic features of their B cell receptors (BCRs) and clonality. Patients and Methods. Questionnaires directed to specific health, social, and environmental conditions were collected in a cohort of 573 CLL patients. For these patients, immunoglobulin heavy chain gene rearrangements were also analyzed in order to gain information about their clonality, IGHV mutational status, and the presence of stereotyped BCRs. Data extracted from the questionnaires were analyzed statistically in the context of immunogenetic features of the cohort. Results. There were no statistically significant differences in the data collected in the survey between patients with mutated and patients with unmutated IGHV. However, patients with oligoclonal CLL reported health conditions such as hypercholesterolemia, hypertension, herpes simplex, tumors, and also, separately, CLL in 1 st degree relatives, more often than their monoclonal counterparts. In patients with stereotyped BCRs, we found more frequent alcohol consumption and gastric infections in subset #1 cases and frequent cholecystectomies and familial CLL in subset #2 cases. Conclusion. To the best of our knowledge, this study is the first to investigate CLL immunogenetic features and clonality in the context of epidemiological data. We reported statistically significant associations suggesting the influence of certain health and social conditions on a number of clonal populations expanding in CLL and also on characteristic BCR features, especially stereotypy.

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Association of various risk factors with chronic lymphocytic leukemia and its cytogenetic characteristics

Cited by 25 publications

References 61 publications

Personal use of hair dyes and risk of leukemia: a systematic literature review and meta‐analysis

Personal use of hair dyes and risk of leukemia: a systematic literature review and meta‐analysis

Review of refractory ceramic fiber (RCF) toxicity, epidemiology and occupational exposure

Profiling of biological and environmental risk factors in immunogenetic subgroups of chronic lymphocytic leukemia - Czech national study

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