Association of variability in body size with neuroimaging metrics of brain health: a population-based cohort study

Sun, Jing; Zeng, Na; Hui, Ying; Li, Jing; Liu, Wenjuan; Zhao, Xinyu; Zhao, Pengfei; Chen, Shuohua; Wu, Shouling; Wang, Zhenchang; Lv, Han

doi:10.1016/j.lanwpc.2024.101015

Cited by 2 publications

(4 citation statements)

References 40 publications

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“…The parameters were listed in Additional File 3 : Table S1. Decreased brain macrostructural volume, impaired microstructural integrity, higher volume of WMH, or the presence of CSVD have been suggested to be associated with worse brain health [ 18 , 33 ].…”

Section: Methodsmentioning

confidence: 99%

“…Acting as a potential neuroinflammation factor [ 16 , 17 ], the alterations in SUA concentration may have a significant impact on the structural and functional integrity of the neural system. Previous research has demonstrated the significance of changes in physiological measurements on brain health [ 18 , 19 ]. Similarly, laboratory assessments are susceptible to fluctuations, particularly in SUA levels.…”

Section: Introductionmentioning

confidence: 99%

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Associations of serum uric acid variability with neuroimaging metrics and cognitive decline: a population-based cohort study

Lv,

Sun,

Zhang

et al. 2024

BMC Med

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Background The relationship between variation in serum uric acid (SUA) levels and brain health is largely unknown. This study aimed to examine the associations of long-term variability in SUA levels with neuroimaging metrics and cognitive function. Methods This study recruited 1111 participants aged 25–83 years from a multicenter, community-based cohort study. The SUA concentrations were measured every two years from 2006 to 2018. We measured the intraindividual SUA variability, including the direction and magnitude of change by calculating the slope value. The associations of SUA variability with neuroimaging markers (brain macrostructural volume, microstructural integrity, white matter hyperintensity, and the presence of cerebral small vessel disease) and cognitive function were examined using generalized linear models. Mediation analyses were performed to assess whether neuroimaging markers mediate the relationship between SUA variation and cognitive function. Results Compared with the stable group, subjects with increased or decreased SUA levels were all featured by smaller brain white matter volume (beta = − 0.25, 95% confidence interval [CI] − 0.39 to − 0.11 and beta = − 0.15, 95% CI − 0.29 to − 0.02). Participants with progressively increased SUA exhibited widespread disrupted microstructural integrity, featured by lower global fractional anisotropy (beta = − 0.24, 95% CI − 0.38 to − 0.10), higher mean diffusivity (beta = 0.16, 95% CI 0.04 to 0.28) and radial diffusivity (beta = 0.19, 95% CI 0.06 to 0.31). Elevated SUA was also associated with cognitive decline (beta = − 0.18, 95% CI − 0.32 to − 0.04). White matter atrophy and impaired brain microstructural integrity mediated the impact of SUA increase on cognitive decline. Conclusions It is the magnitude of SUA variation rather than the direction that plays a critical negative role in brain health, especially for participants with hyperuricemia. Smaller brain white matter volume and impaired microstructural integrity mediate the relationship between increased SUA level and cognitive function decline. Long-term stability of SUA level is recommended for maintaining brain health and preventing cognitive decline.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Associations of serum uric acid variability with neuroimaging metrics and cognitive decline: a population-based cohort study

Lv,

Sun,

Zhang

et al. 2024

BMC Med

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show abstract

“…10 To support this argument, in obesity, whose relationship with dementia has been reported, 11 an increase in body size is associated with greater burden of dilated perivascular spaces, compared to that observed in subjects experiencing body size decrease. 12 Since…”

Section: Failure Of the Glymphatic System As Possible Link Between Lu...mentioning

confidence: 99%

“…To support this argument, in obesity, whose relationship with dementia has been reported, 11 an increase in body size is associated with greater burden of dilated perivascular spaces, compared to that observed in subjects experiencing body size decrease. 12 Since the cerebrospinal venous system is in open communication with the intrathoracic and intra‐abdominal veins, the failure of the GS, likely responsible for dementia in obese subjects, might rely on mechanisms similar to those advocated in LSS.…”

mentioning

confidence: 99%

Failure of the glymphatic system as possible link between lumbar spinal stenosis and dementia

Gallina,

Lolli,

Porfirio

2024

Alzheimer's & Dementia

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Association of variability in body size with neuroimaging metrics of brain health: a population-based cohort study

Cited by 2 publications

References 40 publications

Associations of serum uric acid variability with neuroimaging metrics and cognitive decline: a population-based cohort study

Associations of serum uric acid variability with neuroimaging metrics and cognitive decline: a population-based cohort study

Failure of the glymphatic system as possible link between lumbar spinal stenosis and dementia

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