Association of urinary polycyclic aromatic hydrocarbon metabolites and cardiovascular disease among US population: A cross-sectional study

Mallah, Manthar Ali; Li, Changxing; Mallah, Mukhtiar Ali; Naveed, Muhammad; Liu, Yang; Noreen, Sobia; He, Xiaohai; Wang, Wei; Feng, Feifei; Zhang, Qiao

doi:10.1016/j.envres.2022.112775

Cited by 27 publications

(16 citation statements)

References 47 publications

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“…PAHs exposure have been demonstrated to increase the risk of hypertension, peripheral arterial disease (PAD) [ 29 ], coronary heart disease (CAD) [ 30 , 31 ], myocardial infarction (MI) [ 32 ] and stroke. A cohort of 12,367 workers from different countries has recorded evidence that the Benzo[a]pyrene (B[a]P) exposure indices were positively related with mortality from ischemic heart disease [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Association between urinary biomarkers of polycyclic aromatic hydrocarbons and severe abdominal aortic calcification in adults: data from the National Health and Examination Nutrition Survey

Yang

Zhou

Zhang

et al. 2023

BMC Cardiovasc Disord

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Objective Recent studies have found that polycyclic aromatic hydrocarbons (PAHs) exposure may increase the risk of cardiovascular disease. The present study aimed to explore the association between PAHs exposure and severe abdominal aortic calcification (AAC) in adults. Methods Data were collected from the 2013–2014 National Health and Nutrition Examination Survey. PAHs exposure was analyzed from urinary mono hydroxylated metabolites of PAHs. Logistic regression models and subgroup analysis were performed to explore the association of PAHs exposure with severe AAC prevalence. Results A total of 1,005 eligible individuals were recruited into the study. After adjusting for confounding factors, those with the highest quartiles of 1-hydroxynaphthalene (1-NAP: OR 2.19, 95% CI 1.03–4.68, Pfor trend < 0.001), 2-hydroxynaphthalene (2-NAP: OR 2.22, 95% CI 1.04–4.64, Pfor trend < 0.001) and 1-hydroxypyrene (1-PYR: OR 2.15, 95% CI 1.06–4.33, Pfor trend < 0.001) were associated with an increased prevalence of severe AAC in the adults compared to those who in the lowest quartile. Conclusion This study found that urinary 1-NAP, 2-NAP and 1-PYR were positively associated with severe AAC prevalence in adults.

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Section: Discussionmentioning

confidence: 99%

Association between urinary biomarkers of polycyclic aromatic hydrocarbons and severe abdominal aortic calcification in adults: data from the National Health and Examination Nutrition Survey

Yang

Zhou

Zhang

et al. 2023

BMC Cardiovasc Disord

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“…The toxic effects of PAH on the human body have been studied extensively. Population studies have found that PAH affects multiple systems such as the nervous (Feng et al 2022), cardiovascular (Mallah et al 2022), and renal (Rahman et al 2022) systems, and may lead to the occurrence of chronic diseases such as diabetes (Srivastava 2022) and hypertension (Wang et al 2022a). Moreover, the mixture toxicity of PAH with a series of compounds, is also well studied (Eriksson et al 2022, Kreutzer et al 2022, Wallace et al 2022.…”

Section: Discussionmentioning

confidence: 99%

Association Between Urinary Heterocyclic Aromatic Amines and Mortality in Adults

Zhang

Lin

et al. 2022

Preprint

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Heterocyclic aromatic amines (HAA) are mutagenic compounds; however, their long-term effects on humans remain poorly studied. This study investigated the association between HAA concentration and mortality in adults. Data from the National Health and Nutrition Examination Survey 2013-2014 were linked to mortality data from 2019 and analyzed using Cox regression analysis to determine the association of different HAA with all-cause, cardiovascular disease (CVD), and cancer mortality. Age, sex, education level, race, poverty income ratio, body mass index, smoking status, drinking status, and serum cotinine were included as covariates in three different Cox regression models. This study included 1,713 adults with a median age of 47 years (49.5% men). During a median follow-up at 71 months, 100 deaths occurred. Owing to detection limits, only four had discernible detection rates and were included in our analysis. Among them, only norharman concentration was significantly associated with all-cause and CVD mortality. The hazard ratio (HR) was 1.50 (95% confidence interval: 1.10–2.04) for all-cause mortality when analyzing norharman concentration as a natural log-transformed continuous variable and 3.33 (95% confidence interval: 2.24–4.95) for CVD mortality. Associations remained consistent when norharman concentrations were analyzed as binary variables (split by median). Urinary harman concentration seemed to show a negative association with cancer mortality. No definitive evidence was found of an association between other HAA and mortality. Urinary norharman concentration is associated with all-cause mortality and CVD mortality in adults.

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“…17 As such, the evidence base concerning whether exposure to OFRs and PAEs influences the development of CHD remains rather inconsistent; this means that further large-scale epidemiological studies will be needed to verify the presented results. According to Mallah et al, 13 combined exposure to six common metabolites of PAHs was found to be associated with CHD risk in the general U.S. population. Our research supplemented this evidence with the finding that exposure to phenanthrene can contribute to CHD development among the Chinese population.…”

Section: Associations Between Exposure To a Single Edc And Chd Riskmentioning

confidence: 99%

“…Coronary heart disease (CHD) remains a predominant part of the global disease burden despite large-scale behavioral interventions. , PAEs and PAHs are suspected to be cardiovascular toxicants, , although their effects on the development of CHD are far from clear. For example, it has been observed that human-relevant concentration of diethyl phthalate (DEP) induced human foam cell formation, exhibiting pro-atherogenic effect .…”

Section: Introductionmentioning

confidence: 99%

“…17 A recent cross-sectional study reported a link between total concentrations of six common metabolites of PAHs in urine and the development of CHD and other cardiovascular diseases in the United States general population. 13 However, there is scarce evidence supporting this association, and the mechanisms through which PAH metabolites are connected to CHD have not been elucidated. So far, there is no solid evidence that exposure to OFRs, despite demonstrating potential cardiovascular toxicity, 18 is associated with a risk of developing CHD.…”

Section: Introductionmentioning

confidence: 99%

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Mediating Role of Glucose-Lipid Metabolism in the Association between the Increased Risk of Coronary Heart Disease and Exposure to Organophosphate Esters, Phthalates, and Polycyclic Aromatic Hydrocarbons

Zhang,

Liu,

et al. 2024

Environ. Health

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There is a lack of human evidence concerning the cardiovascular effects of combined exposure to endocrine disruptors. This case-control study sought to investigate coronary heart disease (CHD) associations with exposure to organophosphate flame retardants (OFRs), phthalates (PAEs), and polycyclic aromatic hydrocarbons (PAHs) among 148 adults with coronary-angiography-diagnosed CHD and 320 healthy adults from southern China. The mediating role of glucose-lipid metabolism was also explored. Bayesian kernel machine regression suggested that when exposure status was fixed to the 75th percentile with the median value as the reference, exposure to OFRs, PAEs, and PAHs was associated with an 84% (95% CI: 36%−134%), 132% (12%−252%), and 214% (89%−331%) increased risk of developing CHD, respectively. Weighted quantile sum regression indicated urinary bis(2-butoxyethyl) phosphate (BBOEP), dibutyl phosphate (DBP), monoisononyl phthalate (miNP), and metabolites of phenanthrene may be major contributors to the overall effect of mixtures. In further analyses on identified chemical risk factors, mediation analyses suggested exposure to phenanthrene may increase the risk of CHD via elevating total cholesterol and blood glucose, while exposure to DiNP mainly associates with serum lipids. Besides, we observed a slight mediation effect of oxidative DNA damage between urinary BBOEP and risk of CHD. These results provide potential direction for further experimental studies. Longitudinal evidence is needed to clarify the causation of the results.

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Association of urinary polycyclic aromatic hydrocarbon metabolites and cardiovascular disease among US population: A cross-sectional study

Cited by 27 publications

References 47 publications

Association between urinary biomarkers of polycyclic aromatic hydrocarbons and severe abdominal aortic calcification in adults: data from the National Health and Examination Nutrition Survey

Association between urinary biomarkers of polycyclic aromatic hydrocarbons and severe abdominal aortic calcification in adults: data from the National Health and Examination Nutrition Survey

Association Between Urinary Heterocyclic Aromatic Amines and Mortality in Adults

Mediating Role of Glucose-Lipid Metabolism in the Association between the Increased Risk of Coronary Heart Disease and Exposure to Organophosphate Esters, Phthalates, and Polycyclic Aromatic Hydrocarbons

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