Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999–2002

Hatch, Elizabeth E.; Nelson, James W.; Qureshi, M.M.; Weinberg, Janice; Moore, Lynn L.; Singer, Martha R.; Webster, Thomas F.

doi:10.1186/1476-069x-7-27

Cited by 373 publications

(290 citation statements)

References 48 publications

(47 reference statements)

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“…As an example, diet is also thought to be the primary route of exposure to phthalates (14,15) , which are often added to food packaging materials to increase flexibility and resilience (15,(97)(98)(99)(100) . Phthalate exposure has also been associated with increased risk of obesity (49,101,102) . Data indicate that most people are exposed to both BPA and phthalates, making it difficult to evaluate the individual effects of BPA without considering associations with phthalates (103) .…”

Section: Discussionmentioning

confidence: 99%

Bisphenol A exposure and associations with obesity among adults: a critical review

Oppeneer

Robien

2014

Public Health Nutr.

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Objective: To review the literature on bisphenol A (BPA) exposure and obesity in human populations. Design: Systematic review of the literature via searches of PubMed, EMBASE, Web of Science and reference lists for articles published to 1 August 2014. Setting: China, Italy, Japan, Republic of Korea, Sweden, UK, USA. Subjects: Adults (≥18 years). Results: Eighteen articles were identified and included in the review. Twelve studies included secondary evaluations of BPA exposure and BMI, and six studies evaluated body composition as the primary outcome. All analyses were crosssectional and no study included in the review received a positive quality rating (twelve negative, six neutral). Eight studies observed a statistically significant positive association between urinary or serum BPA levels and BMI, and ten studies observed no association. Studies where BMI was a primary outcome and studies of neutral quality were more likely to observe an association. Conclusions: Study results are conflicting and significant methodological issues limit the ability to draw conclusions from these studies. Prospective studies that measure BPA exposure and changes in body weight and composition are needed to establish temporality, causality and the direction of any observed associations.

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Section: Discussionmentioning

confidence: 99%

Bisphenol A exposure and associations with obesity among adults: a critical review

Oppeneer

Robien

2014

Public Health Nutr.

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“…6,[142][143][144] Phthalates are a group of man-made chemicals widely used in industrial and consumer product applications. 8,145,146 Exposure to phthalates can occur from food sources, plastic containers, flooring materials and wall coverings, medical devices, personal care products, lacquers, varnishes, and coatings. Exposure for infants and children may also come from skin contact with surfaces and frequent mouthing of fingers and other objects (e.g., plastic toys), ingestion of breast milk, infant formula, cow's milk, or food packaging, and through inhalation.…”

Section: Metalsmentioning

confidence: 99%

“…149,150 In 2008 ( ref. 145 ) and 2010 ( ref. 150 ), Hatch et al examined the associations between various urinary phthalate metabolites and BMI values and WC from NHANES.…”

Section: Metalsmentioning

confidence: 99%

“…They found no associations between BMI, WC, and phthalate metabolites measured for children aged 6 to 11 years. 145,150 Trasande et al 151 performed stratified and whole-sample cross-sectional analyses for NHANES children aged 6-19 years (2003-2008) and found that low molecular weight phthalate metabolites were associated with increases in obesity in non-Hispanic black children. 151 Other studies have reported similar results in spite of weak statistical evidence that phthalates increase a child's weight.…”

Section: Metalsmentioning

confidence: 99%

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Chemical and non-chemical stressors affecting childhood obesity: a systematic scoping review

Lichtveld

Thomas

Tulve

2017

J Expo Sci Environ Epidemiol

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Childhood obesity in the United States has doubled over the last three decades and currently affects 17% of children and adolescents. While much research has focused on individual behaviors impacting obesity, little research has emphasized the complex interactions of numerous chemical and non-chemical stressors found in a child's environment and how these interactions affect a child's health and well-being. The objectives of this systematic scoping review were to (1) identify potential chemical stressors in the context of non-chemical stressors that impact childhood obesity; and, (2) summarize our observations for chemical and non-chemical stressors in regards to child-specific environments within a community setting. A review was conducted to identify chemical and non-chemical stressors related to childhood obesity for the childhood life stages ranging from prenatal to adolescence. Stressors were identified and grouped into domains: individual behaviors, family/household behaviors, community stressors, and chemical exposures. Stressors were related to the child and the child's everyday environments and used to characterize child health and well-being. This review suggests that the interactions of chemical and non-chemical stressors are important for understanding a child's overall health and well-being. By considering these relationships, the exposure science research community can better design and implement strategies to reduce childhood obesity.

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“…In mammals, including humans, phthalate exposure is associated with endocrine disruption [15][16][17] and metabolic disorders [18,19]. In rodents, in utero exposure to phthalates results in developmental and reproductive defects similar to those termed testicular dysgenesis syndrome in humans [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): A novel signalling pathway sensitive to phthalates

Eveillard¹,

Mselli-Lakhal²,

Mogha³

et al. 2009

Biochemical Pharmacology

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To cite this version:Alexandre Eveillard, Laïla Mselli-Lakhal, Ariane Mogha, Frédéric Lasserre, Arnaud Polizzi, et al.. Di-(2-ethylhexyl)-phthalate (DEHP) activates the Constitutive Androstane Receptor (CAR): a novel signalling pathway sensitive to phthalates. Biochemical Pharmacology, Elsevier, 2009, 77 (11) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A c c e p t e d M a n u s c r i p t 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 This finding demonstrates that CAR also represents a transcriptional regulator sensitive to phthalates. CAR-mediated effects of DEHP provide a new rationale for most endpoints of phthalates toxicity described previously, including endocrine disruption, hepatocarcinogenesis and the metabolic syndrome.

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Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999–2002

Abstract: Background: Although diet and activity are key factors in the obesity epidemic, laboratory studies suggest that endocrine disrupting chemicals may also affect obesity.

Cited by 373 publications

References 48 publications

Bisphenol A exposure and associations with obesity among adults: a critical review

Bisphenol A exposure and associations with obesity among adults: a critical review

Chemical and non-chemical stressors affecting childhood obesity: a systematic scoping review

Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): A novel signalling pathway sensitive to phthalates

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