Association of Urinary Lead and Cadmium Levels, and Serum Lipids with Subclinical Arteriosclerosis: Evidence from Taiwan

Lin, Chien‐Yu; Hsu, Sandy Huey-Jen; Chen, Ching-Way; Wang, Chikang; Sung, Fung‐Chang; Su, Ta‐Chen

doi:10.3390/nu15030571

Cited by 5 publications

(4 citation statements)

References 47 publications

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“…Moreover, simultaneous exposure to low doses of Pb and Cd may lead to cumulative cellular damage through shared molecular pathways. Previous animal studies and epidemiological research have proposed that these metals may exert synergistic effects on diverse health indicators, including lipid metabolism, biomarkers of oxidative stress, renal function, and blood pressure [3,[41][42][43]. In our prior investigation, we also found that the combined exposure to Pb and Cd might result in synergistic impacts on apoptotic microparticles [12].…”

Section: Discussionmentioning

confidence: 56%

The Association among Urinary Lead and Cadmium, Serum Adiponectin, and Serum Apoptotic Microparticles in a Young Taiwanese Population

Lin,

Wang,

Sung

et al. 2023

Nutrients

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Previous studies reported that lead (Pb) and cadmium (Cd) exposure are linked to changes in serum adiponectin; an adipokine that promotes glycolysis and inhibits gluconeogenesis to regulate glucose metabolism. However, no study has ever explored the relationship between exposure to these two heavy metals and adiponectin in adolescents and young adults. Additionally, the role of adiponectin in the relationship between Pb and Cd exposure and vascular endothelial cell apoptosis has never been investigated. In this study, 724 Taiwanese participants, aged 12 to 30 years, were enrolled to investigate the association among urinary lead and cadmium, serum adiponectin, and apoptotic microparticles (CD31+/CD42a−, CD31+/CD42a+, and CD14). The results of the current study revealed a statistically significant inverse association between urine Pb and Cd levels and adiponectin levels, as well as a positive association with apoptotic microparticles (CD31+/CD42a−, CD31+/CD42a+, and CD14). Adiponectin was also inversely correlated with CD31+/CD42a− and CD31+/CD42a+. Moreover, when subjects with both Pb and Cd levels above the 50th percentile were compared to those below it, the former group exhibited the lowest average adiponectin value. Additionally, a more pronounced positive association between heavy metals and apoptotic microparticles (CD31+/CD42a− and CD31+/CD42a+) was observed when adiponectin levels were lower. Furthermore, an interaction between adiponectin and heavy metals was identified in the relationship between these metals and CD31+/CD42a−. In conclusion, these findings suggest that Pb and Cd exposure may have an adverse effect on adiponectin, and it may play a role in the link between heavy metal exposure and the dysfunction of vascular endothelial cells. Future studies are needed to establish whether a causal relationship exists.

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Section: Discussionmentioning

confidence: 56%

The Association among Urinary Lead and Cadmium, Serum Adiponectin, and Serum Apoptotic Microparticles in a Young Taiwanese Population

Lin,

Wang,

Sung

et al. 2023

Nutrients

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“…The use of prebiotics represents a potential strategy for mitigating cadmium toxicity (Tinkov et al, 2018 ). This discovery unveils novel therapeutic targets and insights for treating cadmium-induced disorders, necessitating further investigation into the underlying mechanisms (Lin C. Y. et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Visual trends and hot research on the relationship between intestinal microbiota and major lipids: a bibliometric analysis

Sun,

Wan,

Gui

et al. 2024

Front. Microbiol.

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ObjectiveThe association between intestinal microbiota and lipids has garnered significant scholarly interest. This study analyzes pertinent literature on intestinal microbiota and lipids to offer scientific guidance for future advancements and research directions.MethodsArticles focusing on intestinal microbiota and lipids were obtained from the Web of Science Core Collection (WoSCC). Following a rigorous screening process, 12,693 articles were included in the study. The collected data was processed comprehensively and visually analyzed using various academic tools such as CiteSpace, VOSviewer, R software, and Scimago Graphica.ResultsThe field of intestinal microbiota and its relationship with major lipids has witnessed a significant surge in scholarly attention, as indicated by the upward trend observed in related articles. Among countries, China had emerged as the leading contributor in publication output, with Chinese Acad Sci being the most prolific institution in this field. Notably, Nutrients and Nature were the prominent journals that published many articles and garnered the highest number of co-citations. Scholars have widely recognized Patrice D Cani's notable contributions in this field. Current research endeavors have focused on obesity, insulin resistance, metabolism, growth performance, the gut-brain axis, and others.ConclusionsOur analysis identified four primary research trends: “biochemical pathways,” “exploration of diseases,” “intervention and effect,” and “health and diet.” Future scholars must devote more attention to intestinal microbiota and major lipids to advance our understanding of human health.

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“…A recent meta-analysis demonstrated that elevated Cd was correlated with increased TC levels (OR = 1.48, 95% CI: 1.10–2.01), increased LDL-C levels (OR = 1.31, 95% CI 0.99–1.73), and decreased HDL-C levels (OR = 1.96, 95% CI: 1.09–3.55) [ 41 ]. Several large-scale research studies have concluded that high Cd exposure increases the risk of dyslipidemia [ 33 , 42 ]. Most studies on the mechanism of Cd altering lipid metabolism have consistently shown that Cd interferes with the body’s antioxidant system.…”

Section: Discussionmentioning

confidence: 99%

Associations of Urinary Heavy Metal Mixtures with High Remnant Cholesterol among US Adults: Evidence from the National Health and Nutrition Examination Survey (1998–2018)

Li,

Cheng,

Yang

et al. 2024

Toxics

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The main objective of our study is to explore the associations between combined exposure to urinary heavy metals and high remnant cholesterol (HRC), a known cardiovascular risk factor. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018, we conducted a cross-sectional analysis of 5690 participants, assessing urinary concentrations of ten heavy metals. Ten heavy metals in urine were measured by inductively coupled plasma mass spectrometry (ICP-MS). Fasting residual cholesterol ≥0.8 mmol/L was defined as HRC (using blood samples). Statistical analyses included weighted multivariable logistic regression, weighted quantile sum (WQS) regression, quantile g-computation (qgcomp), and Bayesian kernel machine regression (BKMR) to evaluate the associations of heavy metal exposure with HRC. Stratified analyses based on individual characteristics were also conducted. Multivariable logistic regression found that the four metals (OR Q4 vs. Q1: 1.33, 95% CI: 1.01–1.75 for barium (Ba); OR Q4 vs. Q1: 1.50, 95% CI: 1.16–1.94 for cadmium (Cd); OR Q4 vs. Q1: 1.52, 95% CI: 1.15–2.01 for mercury (Hg); OR Q4 vs. Q1: 1.35, 95% CI: 1.06–1.73 for lead (Pb)) were positively correlated with the elevated risk of HRC after adjusting for covariates. In addition, all three mixed models, including WQS (OR: 1.25; 95% CI: 1.07–1.46), qgcomp (OR: 1.17; 95% CI: 1.03–1.34), and BKMR, consistently showed a significant positive correlation between co-exposure to heavy metal mixtures and HRC, with Ba and Cd being the main contributors within the mixture. These associations were more pronounced in younger adults (20 to 59 years), males, and those with a higher body mass index status (≥25 kg/m2). Our findings reveal a significant relationship between exposure to the mixture of heavy metals and HRC among US adults, with Ba and Cd being the major contributors to the mixture’s overall effect. Public health efforts aimed at reducing heavy metal exposure can help prevent HRC and, in turn, cardiovascular disease.

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Association of Urinary Lead and Cadmium Levels, and Serum Lipids with Subclinical Arteriosclerosis: Evidence from Taiwan

Cited by 5 publications

References 47 publications

The Association among Urinary Lead and Cadmium, Serum Adiponectin, and Serum Apoptotic Microparticles in a Young Taiwanese Population

The Association among Urinary Lead and Cadmium, Serum Adiponectin, and Serum Apoptotic Microparticles in a Young Taiwanese Population

Visual trends and hot research on the relationship between intestinal microbiota and major lipids: a bibliometric analysis

Associations of Urinary Heavy Metal Mixtures with High Remnant Cholesterol among US Adults: Evidence from the National Health and Nutrition Examination Survey (1998–2018)

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