Association of urinary heavy metals co-exposure and adult depression: Modification of physical activity

Fu, Xihang; Li, Huiru; Song, Lingling; Cen, Man-qiu; Wu, Jing

doi:10.1016/j.neuro.2023.01.008

Cited by 8 publications

(2 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous research has indicated that heavy metal exposure can initiate neuro-in ammation, oxidative stress, hormonal imbalances, and disruptions to neurotransmitters like dopamine and serotonin, all of which can contribute to the etiology of depressive disorders. [49][50][51][52] For example, Rokoff et al show that prenatal exposure to Pb was found to be linked to increased anxiety symptoms during adolescence. In contrast, prenatal exposure to Mn was positively correlated with internalizing symptoms, particularly among girls from mid-childhood through adolescence.…”

Section: Discussionmentioning

confidence: 99%

Akkermansia muciniphila modifies the association between metal exposure during pregnancy and depressive symptoms in late childhood

Midya,

Nagdeo,

Lane

et al. 2024

Preprint

View full text Add to dashboard Cite

Emerging research suggests that exposures to metals during pregnancy and gut microbiome (GM) disruptions are associated with depressive disorders in childhood. Akkermansia muciniphila, a GM bacteria, has been studied for its potential antidepressant effects. However, its role in the influence of prenatal metal exposures on depressive symptoms during childhood is unknown. Leveraging a well-characterized pediatric longitudinal birth cohort and its microbiome substudy (n=112) and using a state-of-the-art machine-learning model, we investigated whether the presence of A.muciniphila in GM of 9-11-year-olds modifies the associations between exposure to a specific group of metals (or metal-clique) during pregnancy and concurrent childhood depressive symptoms. Among children with no A.muciniphila, a metal-clique of Zinc-Chromium-Cobalt was strongly associated with increased depression score (P<0.0001), whereas, for children with A.muciniphila, this same metal-clique was weakly associated with decreased depression score(P<0.4). Our analysis provides the first exploratory evidence hypothesizing A.muciniphila as a probiotic intervention attenuating the effect of prenatal metal-exposures-associated depressive disorders in late childhood.

show abstract

Section: Discussionmentioning

confidence: 99%

Akkermansia muciniphila modifies the association between metal exposure during pregnancy and depressive symptoms in late childhood

Midya,

Nagdeo,

Lane

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Previous research has indicated that heavy metal exposure can initiate neuroin ammation, oxidative stress, hormonal imbalances, and disruptions to neurotransmitters like dopamine and serotonin, all of which can contribute to the etiology of depressive disorders. [55][56][57][58] For example, Rokoff et al show that prenatal exposure to Pb was found to be linked to increased anxiety symptoms during adolescence. In contrast, prenatal exposure to Mn was positively correlated with internalizing symptoms, particularly among girls from mid-childhood through adolescence.…”

Section: Discussionmentioning

confidence: 99%

Akkermansia muciniphila may mediate the association between prenatal metal mixture exposure and childhood depressive symptoms

Nagdeo,

Midya,

Lane

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Prenatal metal exposure may be associated with childhood depressive symptoms. Emerging research suggests links between gut microbiome (GM) disruptions and depressive disorders. Akkermansia muciniphila, a GM bacteria, has been studied for its potential antidepressant effects. However, its role in mediating the association between prenatal metal exposures and depressive symptoms in later childhood is not known. We aim to estimate the associations between prenatal mixed metal exposures, A. mucinipnila presence in the gut microbiome at 9-11 years old, and concurrent depressive symptoms. Methods: We leverage existing data from a subset of 112 participants in the Programming Research in Obesity, Growth, Environment, and Social Stressors (PROGRESS) cohort. Metal concentrations (Pb, As, Cd, Cr, Zn, Se, Sb, Cu, Cs, Co, Mn) were measured in 2nd and 3rd trimester maternal whole blood. Stool samples were collected at 9–11 years of age and underwent metagenomic sequencing to assess the GM. The presence of A. muciniphila was detected using GM data. Children’s Depression Inventory (CDI) was administered at 9-11 years. We used weighted quantile sum (WQS) regression to separately estimate associations between prenatal metal mixture exposure at 2nd and 3rd trimesters and CDI. We used a nonparametric bootstrap approach to estimate the proportion of these associations mediated by A. muciniphila. Results: A. muciniphila was detected in 24% of participants. The presence of A. muciniphila was associated with a significantly decreased log-transformed, t-score normalized CDI score (log tCDI) (ß=-0.13, 95%CI=[-0.21,-0.04]), suggesting a protective effect. Second and 3rd-trimester metal mixtures were associated with increased log tCDI (ß=0.06 per increase in quartile, 95%CI=[0.01,0.10] and ß=0.03 per increase in quartile, 95%CI=[-0.02,0.09], respectively). A quartile increase in these metal mixtures trended towards decreased odds of A. muciniphila (OR=0.54, 95%CI=[0.23,1.24] and OR=0.58, 95%CI=[0.23,1.49] at 2nd and 3rd trimesters respectively). The presence of A. muciniphila may mediate the association between the 2nd-trimester metal mixture and log tCDI by 34%. Conclusion: We found suggestive evidence that A. muciniphila may attenuate the association between prenatal metal exposures and childhood depressive symptoms. A. muciniphila supplementation may be a promising intervention strategy to mitigate metal-associated depressive symptoms. Additional studies are needed to confirm these findings.

show abstract

Independent and joint associations of multiple metals exposure with vital capacity index: a cross-sectional study in Chinese children and adolescents

Xiang,

Wang,

Deng

et al. 2024

Int Arch Occup Environ Health

View full text Add to dashboard Cite

Association of urinary heavy metals co-exposure and adult depression: Modification of physical activity

Cited by 8 publications

References 43 publications

Akkermansia muciniphila modifies the association between metal exposure during pregnancy and depressive symptoms in late childhood

Akkermansia muciniphila modifies the association between metal exposure during pregnancy and depressive symptoms in late childhood

Akkermansia muciniphila may mediate the association between prenatal metal mixture exposure and childhood depressive symptoms

Independent and joint associations of multiple metals exposure with vital capacity index: a cross-sectional study in Chinese children and adolescents

Contact Info

Product

Resources

About