Association of urinary concentrations of bisphenols with type 2 diabetes mellitus: A case-control study

Duan, Yanmin; Yao, Yiming; Wang, Bin; Han, Liping; Wang, Lei; Sun, Hongwen; Chen, Liming

doi:10.1016/j.envpol.2018.09.093

Cited by 100 publications

(48 citation statements)

References 61 publications

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“…Epidemiological and prospective studies associated BPA exposure with alterations in glucose homeostasis or T2D incidence, independently of obesity or other traditional factors (Lang et al, 2008;Shankar and Teppala, 2011;Beydoun et al, 2014;Ranciere et al, 2019). Recent epidemiological data associated BPS urine levels with T2D development in a case-cohort study (Ranciere et al, 2019) and a case-control study (Duan et al, 2018). BPF has been recently associated with abdominal 58 obesity in children (Jacobson et al, 2019), but association with T2D is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway

Marroquí

Martı́nez-Pinna

Castellano-Muñoz

et al. 2020

Preprint

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Bisphenol-S (BPS) and Bisphenol-F (BPF) are current Bisphenol-A (BPA) substitutes. Here we used pancreatic β-cells from wild type (WT) and estrogen receptor β (ERβ) knockout (BERKO) mice to investigate the effects of BPS and BPF on insulin secretion, and the expression and activity of ion channels involved in β-cell function. BPS or BPF rapidly increased insulin release and diminished ATP-sensitive K+ (KATP) channel activity. Similarly, 48 h treatment with BPS or BPF enhanced insulin release and decreased the expression of several ion channel subunits in β-cells from WT mice, yet no effects were observed in cells from BERKO mice. PaPE-1, a ligand designed to preferentially trigger extranuclear-initiated ER pathways, mimicked the effects of bisphenols, suggesting the involvement of extranuclear-initiated ERβ pathways. Molecular dynamics simulations indicated differences in ERβ ligand-binding domain dimer stabilization and solvation free energy among different bisphenols and PaPE-1. Our data suggest a mode of action involving ERβ whose activation alters three key cellular events in β-cell, namely ion channel expression and activity, and insulin release. These results may help to improve the hazard identification of bisphenols.

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Section: Introductionmentioning

confidence: 99%

Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway

Marroquí

Martı́nez-Pinna

Castellano-Muñoz

et al. 2020

Preprint

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show abstract

“…Results of both animal and human studies have revealed the toxic effects of bisphenols. Increased levels of bisphenols are found in human body fluids including in urine, serum, placental tissue, umbilical cord blood, and breast milk [60,78,84,97,124]. These chemicals affect animal and human organisms by interactions with estrogen, androgen, and aryl hydrocarbon receptors, and disrupt the function of the endocrine system, including altering the functions of sex hormones, insulin, leptin, adiponectin, or thyroxin.…”

Section: Discussionmentioning

confidence: 99%

“…Another study from China reported that increased urinary BPA levels of both girls and boys (aged 8-15 years) are related to increased body mass index [81]. In a Chinese population case-control study of 251 cases of diabetes mellitus type 2 (DM2) and 251 controls, urinary concentrations of bisphenols (BPAF and BPS) were found to be positively correlated with DM2 [78]. A meta-analysis study determined that BPA toxicity is related to an increased risk of DM2; they reported that both urine and serum BPA levels are positively associated with the risk of DM2 [80].…”

Section: Obesity and Diabetesmentioning

confidence: 99%

Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability

Kim

Kumar

et al. 2019

IJERPH

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Bisphenols are widely used in the synthesis of polycarbonate plastics, epoxy resins, and thermal paper, which are used in manufacturing items of daily use. Packaged foods and drinks are the main sources of exposure to bisphenols. These chemicals affect humans and animals by disrupting the estrogen, androgen, progesterone, thyroid, and aryl hydrocarbon receptor functions. Bisphenols exert numerous harmful effects because of their interaction with receptors, reactive oxygen species (ROS) formation, lipid peroxidation, mitochondrial dysfunction, and cell signal alterations. Both cohort and case-control studies have determined an association between bisphenol exposure and increased risk of cardiovascular diseases, neurological disorders, reproductive abnormalities, obesity, and diabetes. Prenatal exposure to bisphenols results in developmental disorders in animals. These chemicals also affect the immune cells and play a significant role in initiating the inflammatory response. Exposure to bisphenols exhibit age, gender, and dose-dependent effects. Even at low concentrations, bisphenols exert toxicity, and hence deserve a critical assessment of their uses. Since bisphenols have a global influence on human health, the need to discover the underlying pathways involved in all disease conditions is essential. Furthermore, it is important to promote the use of alternatives for bisphenols, thereby restricting their uses.

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“…Results of both animal and human studies have revealed the toxic effects of bisphenols. Increased levels of bisphenols are found in human body fluids including in urine, serum, placental tissue, umbilical cord blood, and breast milk [62,79,85,99,122]. These chemicals affect animal and human organisms by interactions with estrogen, androgen, and aryl hydrocarbon receptors, and disrupt the function of the endocrine system, including altering the functions of sex hormones, insulin, leptin, adiponectin or thyroxin.…”

Section: Discussionmentioning

confidence: 99%

“…Another study from China reported that increased urinary BPA levels of both girls and boys (age, 8-15 years) are related to increased body mass index [82]. In a Chinese population case-control study of 251 cases of diabetes mellitus type 2 (DM2) and 251 controls, urinary concentrations of bisphenols (BPAF and BPS) were found to be positively correlated with DM2 [79]. A meta-analysis study determined that BPA toxicity is related to an increased risk of DM2; they reported that both urine and serum BPA levels are positively associated with the risk of DM2 [81].…”

Section: Obesity and Diabetesmentioning

confidence: 99%

Bisphenols as A Legacy Pollutant, and Their Effects on Organ Vulnerability

Kim¹,

Kumar²,

Kumar³

et al. 2019

Preprint

View full text Add to dashboard Cite

Bisphenols are widely used in the synthesis of polycarbonate plastics, epoxy resins and thermal paper, which are used in manufacturing items of daily use. Packaged foods and drinks are the main sources of exposure to bisphenols. These chemicals affect humans and animals by disrupting the estrogen, androgen, progesterone, thyroid, and aryl hydrocarbon receptor functions. Bisphenols exert numerous harmful effects because of their interaction with receptors, ROS formation, lipid peroxidation, mitochondrial dysfunction, and cell signal alterations. Both cohort and case-control studies have determined an association between bisphenol exposure and increased risk of cardiovascular diseases, neurological disorders, reproductive abnormalities, obesity, and diabetes. Prenatal exposure to bisphenol results in developmental disorders in animals. These chemicals also affect the immune cells and play a significant role in initiating the inflammatory response. Exposure to bisphenols exhibit age, gender, and dose-dependent effects. Even at low concentrations, bisphenols exert toxicity, and hence deserve a critical assessment for their uses. Since bisphenols have a global influence on human health, the need to discover the underlying pathways involved in all disease conditions is essential. Furthermore, it is important to promote the use of alternatives for bisphenols, thereby restricting their uses.

show abstract

Association of urinary concentrations of bisphenols with type 2 diabetes mellitus: A case-control study

Cited by 100 publications

References 61 publications

Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway

Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway

Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability

Bisphenols as A Legacy Pollutant, and Their Effects on Organ Vulnerability

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