Association of Urinary Albumin Excretion with Insulin Resistance in Japanese Subjects: Impact of Gender Difference on Insulin Resistance

Abstract

Objective To investigate the relationship between homeostasis model assessment for insulin resistance (HOMA-R)

Urinary Albumin Excretion During Angiotensin II Receptor Blockade: Comparison of Combination Treatment With a Diuretic or a Calcium-Channel Blocker

“…Although UACR decreased significantly in both treatment groups, the magnitude of the reduction was greater in the ARB/diuretic group than in the ARB/CCB group. In addition, these results were obtained even though the ARB/ CCB combination might have more beneficial effects on surrogate markers of oxidative stress, inflammation, and insulin resistance, which are involved in the development of albuminuria, [9][10][11] than the ARB/diuretic combination. On the other hand, the decrease in eGFR was greater when an ARB was combined with a diuretic than with a CCB.…”

“…These results might be explained by the fact that thiazide diuretics reduced UAE through the decrease of glomerular capillary pressure and enhanced nocturnal BP decline. [6][7][8] On the other hand, it has been demonstrated that the RAS inhibitor/CCB combination decreased oxidative stress, inflammation, and insulin resistance, which have been reported associated with increased UAE in the observational studies, [9][10][11] more than the RAS inhibitor/diuretic combination. 12,13 Nevertheless, we hypothesized that the angiotensin II receptor blocker (ARB)/diuretic combination decreases UAE to a greater extent than the ARB/CCB combination through a mechanism related to a greater reduction of nocturnal BP.…”

Elevated Brachial-Ankle Pulse Wave Velocity Is Independently Associated with Microalbuminuria in a Rural Population

“…Metabolic changes caused by hyperglycemia, for example, chronic inflammation triggered by reactive oxygen species, inflammatory cytokines and growth factors, are associated with generalized and glomerular endothelial dysfunction (25). Several previous studies found that higher HOMA IR was associated with microalbuminuria (4, 8, 27). Recently, evidence has emerged that high pulse pressure may have an important effect on albuminuria.…”

“…Regarding gender differences, Utsunomiya et al (27) found that central obesity and HOMA IR were important factors increasing UACR in men, but not in women. A gender-specific hormonal effect was suggested as a possible factor.…”

Metabolik Sendrom Hastalarında Erken Dönem Böbrek Hasarının Saptanmasında Mikroalbuminuri, Sistatin-C ve Tc99m Mag–3 Böbrek Sintigrafisi Yöntemlerinin Karşılaştırılması

“…Mikroalbüminüri, özellikle diyabete bağlı erken renal hastalığın tanısında sıkça kullanılan bir yöntemdir. Çeşitli araştırmalarda diyabetiklerde ve hipertansiflerde mikroalbüminüri prevalansı %10-40 arasında bulunmuştur (15,16). MetS'li hastalarda, erken renal hasarın tanısının, uygulaması kolay, hızlı ve güvenilir bir metodla ölçümü önemlidir; çünkü renal hasar gelişimi ve ilerleyişi erken tanı ve agresif tedavi ile engellenebilir veya yavaşlatılabilir (17).…”