Association of uric acid with cardiovascular risk in Brazilian children and adolescents

Moulin-Mares, Stephanie.R.A.; Oliosa, Polyana Romano; Faria, Eliane Rodrigues de; Zago-Gomes, Maria P.; Mill, José Geraldo

doi:10.1016/j.numecd.2020.09.012

Cited by 23 publications

(18 citation statements)

References 43 publications

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“…The correlation between uric acid and metabolic syndrome components has been widely assessed in adults. However, there is less data regarding such relationships in children and adolescents (12).…”

Section: Discussionmentioning

confidence: 99%

“…Investigating Brazilian children suggested that higher SUA values were correlated with overweight/obesity, high waist circumference, dyslipidemia, high body fat percentage, insulin resistance, and metabolic syndrome (12).…”

Section: Discussionmentioning

confidence: 99%

“…The SUA was determined on a standard autoanalyzer with a Uri case and reagent. Uric acid values of >90 th percentile were considered high (12).…”

Section: Participants and Methodsmentioning

confidence: 99%

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The Relationship Between Serum Uric Acid and Cardiometabolic Risk Factors in Iranian Children and Adolescents

et al. 2021

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Context: There has been an increasing interest in epidemiological and clinical studies concerning the role of uric acid in cardiometabolic diseases, especially in children and adolescents. However, these potential relationships remain undiscovered; accordingly, its pathophysiological mechanisms remain unrecognized. This study aimed to assess the potential association between Serum Uric Acid (SUA) levels and cardiometabolic risk factors in a population-based sample of Iranian children and adolescents. Objectives: This study aimed to assess the potential association between Serum Uric Acid (SUA) levels and cardiometabolic risk factors in a population-based sample of Iranian children and adolescents. Methods: The data of 595 individuals aged 7-18 years were assessed in this research. Anthropometric measurements and laboratory tests were performed according to standardized protocols. Results: The Mean±SD age of the 595 explored students was 12.39±3.07 years. The overall Mean±SD SUA level of the study participants was measured as 4.22±1.13 mg/dL, with significant gender-wise differences (4.04±0.97 mg/dL vs 4.38±1.24 mg/dL, respectively; P<0.05). The prevalence of hyperuricemia based on the 90th percentile of SUA levels was equal to 10.6%. There was a positive association between SUA levels and abdominal obesity (waist circumference: ≥90th percentile) [Odds Ratio (OR): 1.54; 95% Confidence Interval (CI): 1.26 to 1.86] and general obesity [gender-specific Body Mass Index (BMI) for >95th percentile] (OR: 2.32; 95% CI: 1.74 to 3.11). Conclusions: This study suggested BMI and waist circumference as cardiometabolic risk factors, i.e. significantly associated with SUA levels in children and adolescents.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Relationship Between Serum Uric Acid and Cardiometabolic Risk Factors in Iranian Children and Adolescents

et al. 2021

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“…Several cross-sectional studies in pediatric populations, primarily performed in obese children, demonstrated that high UA levels are associated to metabolic syndrome (MetS) and its individual components, nonalcoholic fatty liver disease, reduced estimated glomerular ltration rate (eGFR) and glucose dysmetabolism [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Uric acid and cardiometabolic risk profile in youths with type 1 diabetes: sex-related associations

Bonito¹,

Rosanio

Marcovecchio

et al. 2022

Preprint

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The aim of this study was to investigate the association between uric acid (UA) and cardiometabolic risk factors (CMRFs) by sex in youths with type 1 diabetes (T1D). Retrospective data collected from 1323 youths (5-18 years; 716 boys) with T1D recruited in 9 Italian Pediatric Diabetes Centers were analyzed. CMRFs included UA, HbA1c, blood pressure (BP), cholesterol (TC), HDL, triglycerides (TG), neutrophils (N) and lymphocytes (L) count, glomerular filtration rate (eGFR) (calculated using Schwartz-Lyon equation). The distribution of CMRFs was analyzed in sex-specific tertiles of UA. In the whole study population, statistically significant differences were found across UA tertiles for age, BMI, daily insulin dose, HbA1c, HDL, TG, TG/HDL ratio, TC/HDL ratio, SPISE index, N/L ratio, systolic BP, eGFR (p =0.01-0.0001). The highest tertile of UA was associated with 1,5-3,6 fold increased risk of high TG/HDL ratio, TC/HDL ratio, high BP, and MRGFR, compared to the lowest tertile in boys. Instead, in girls the highest tertile of UA was associated with two-fold increased risk of TC/HDL ratio, N/L ratio and MRGFR. Uric acid may represent a useful marker for identifying youth with T1D at high cardiometabolic risk, and association appears to vary by sex.

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“…Future studies should focus on investigating the association with diet composition, obesity duration and the eventual risk for cardiovascular complications.mostly with hypertriglyceridemia and decreased HDL cholesterol [7][8][9]. In healthy adolescents as well as in obese youth with type 2 diabetes, hyperuricemia was identi ed as an independent risk factor for arterial hypertension in young adulthood [10,11].Obesity is a well-established major risk factor for hyperuricemia in adults and children [12][13][14][15]. Elevated SUA concentrations are reported in up to 40% of obese children or adolescents [16].…”

mentioning

confidence: 99%

Prevalence and determinants of hyperuricemia in multi-ethnic Belgian population of inner-city living children and adolescents with obesity

Nauwynck

Vanbesien

Staels

et al. 2022

Preprint

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Background Hyperuricemia in childhood obesity associates variably with distinct components of the metabolic syndrome. We aimed to investigate the prevalence of hyperuricemia in an ethnically diverse pediatric obese population in Brussels using age and sex-specific serum uric acid (SUA) reference ranges. Methods We performed a cross-sectional analysis of data from overweight/obese children at Universitair Ziekenhuis Brussel between 2013 and 2017. Hyperuricemia was defined by a SUA above the assay specific and age and gender defined reference range. Results Among 388 children and adolescents, 9% were overweight, 16.2% had class I obesity, 27.8% had class II obesity and 46.9% had class III obesity. Median SUA was 4.8 mg/dL, with 20.6% patients showing an elevated SUA. Degree of general and central obesity, pubertal status, gender, descent and the presence of metabolic syndrome and insulin resistance were not significantly different between those with and without hyperuricemia. Median waist-to-height ratio, serum triglycerides and insulin resistance were significantly higher in Turkish children compared to children of other descent. Conclusion Hyperuricemia was not associated with age, ethnicity, severity of global/central obesity, metabolic syndrome or its components. Future studies should focus on investigating the association with diet composition, obesity duration and the eventual risk for cardiovascular complications.

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Association of uric acid with cardiovascular risk in Brazilian children and adolescents

Cited by 23 publications

References 43 publications

The Relationship Between Serum Uric Acid and Cardiometabolic Risk Factors in Iranian Children and Adolescents

The Relationship Between Serum Uric Acid and Cardiometabolic Risk Factors in Iranian Children and Adolescents

Uric acid and cardiometabolic risk profile in youths with type 1 diabetes: sex-related associations

Prevalence and determinants of hyperuricemia in multi-ethnic Belgian population of inner-city living children and adolescents with obesity

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