Association of Ureaplasma Urealyticum Infection of the Lower Respiratory Tract With Chronic Lung Disease and Death in Very-Low-Birth-Weight Infants

Antenatal exposure to Ureaplasma species exacerbates bronchopulmonary dysplasia synergistically with subsequent prolonged mechanical ventilation in preterm infants

“…The presence of Ureaplasma species in the maternal upper genital tract or in the neonatal airway has a close relationship with adverse neonatal outcomes including preterm delivery and the development of BPD (7)(8)(9)(10)(11). On the other hand, exposure to antenatal infection or inflammation triggered by bacteria other than Ureaplasma species may also have an important pathogenic role in the development of BPD (12)(13)(14).…”

Characterization of Ureaplasmas Isolated from Preterm Infants with and without Bronchopulmonary Dysplasia

“…are the most common microorganisms isolated from inflamed placentas and the lower respiratory tracts of neonates and are proven causes of neonatal pneumonia (4). Since initial reports associating ureaplasmal colonization and development of BPD were published in 1988 (5,23,26), more than 30 studies have been conducted. Most, but not all, have supported this association, despite major changes in the pulmonary management of very-low-birth-weight infants, such as exogenous surfactant, antenatal corticosteroid administration, and high frequency ventilation.…”

Nuclear Factor κB Activation in Pulmonary Leukocytes from Infants with Hyaline Membrane Disease: Associations with Chorioamnionitis and Ureaplasma urealyticum Colonization

“…We focused on pulmonary inflammatory cells and related NF-B activation to TNF-␣ and IL-8 levels in tracheal aspirates from these infants. Perinatal factors that may contribute to lung inflammation include chorioamnionitis (21,22) and Ureaplasma urealyticum colonization/infection of the airway (23)(24)(25)(26)(27). We determined whether these conditions are also associated with evidence of NF-B activation in the infant lung.…”