Association of Untreated Metabolic Syndrome With Moderate to Severe Periodontitis in Thai Population

Thanakun, Supanee; Watanabe, Hisashi; Thaweboon, Sroisiri; Izumi, Yuichi

doi:10.1902/jop.2014.140105

Cited by 28 publications

(30 citation statements)

References 47 publications

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“…Severe periodontitis defined by the CDC/AAP definition was associated with MetS among men (RR: 1.43, 95% CI: 1.17‐1.73) compared with no or mild periodontitis in this study. This result corroborates the findings of previous studies about the association of periodontal disease and MetS . Nesbitt et al reported the association between moderate/severe alveolar bone loss and MetS (OR = 2.61).…”

Section: Discussionsupporting

confidence: 91%

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The severity of periodontitis and metabolic syndrome in Korean population: The Dong‐gu study

Kim

Shin

Kweon

et al. 2017

J of Periodontal Research

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Section: Discussionsupporting

confidence: 91%

“…Many previous studies have shown that MetS affects periodontal disease; however, a few studies have shown an association between periodontitis and MetS . The contribution of the severity of periodontitis to MetS is not yet well determined.…”

Section: Discussionmentioning

confidence: 97%

The severity of periodontitis and metabolic syndrome in Korean population: The Dong‐gu study

Kim

Shin

Kweon

et al. 2017

J of Periodontal Research

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“…Further, the Galbraith plots showed that the studies performed by Shi et al, Purwar et al, Mendoza-Azpur et al, Thanakun et al, and Karthikeyan et al (L1) [30, 31, 49, 51, 52]; Mendoza-Azpur et al and Sete et al (A1) [16, 31]; and Purwar et al (L2) [57] were located outside of the two lines in the Galbraith plots of the subgroups of BMI <30. After removing the outliers, the heterogeneities effectively decreased, and the results were not materially changed in the subgroups of BMI <30 (L1: SMD = 0.796, 95% CI: 0.572–1.020, P = 0.000; I 2 = 40.9, P = 0.095; A1: SMD = −0.251, 95% CI: −0.408 to −0.095, P = 0.002; I 2 = 13.6, P = 0.323; L2: SMD = −0.162, 95% CI: −0.417 to 0.094, P = 0.215; I 2 = 0.0, P = 0.556).…”

Section: Resultsmentioning

confidence: 98%

Association of circulating leptin and adiponectin with periodontitis: a systematic review and meta-analysis

et al. 2017

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BackgroundThis study aimed to assess the difference in serum levels of leptin and adiponectin in patients with periodontitis and in periodontally healthy individuals and evaluate the changes in circulating leptin and adiponectin after periodontal therapy. Leptin and adiponectin are the most generally studied adipokines that function as inflammatory cytokines. Although the association between periodontitis and serum levels of leptin and adiponectin has been studied extensively, the results were not consistent.MethodsA systematic search of the Pubmed, Embase, Web of Science, and Cochrane Library up to September 2016 was conducted. The studies were screened and selected by two writers according to the specific eligibility criteria. The quality of included cross-sectional studies was assessed using the quality assessment form recommended by the Agency for Healthcare Research and Quality and Methodological Index for Nonrandomized Studies. The meta-analyses were conducted using the STATA 12.0 software.ResultsA total of 399 manuscripts were yielded and 25 studies were included in the present meta-analysis. Significantly elevated serum levels of leptin and decreased serum levels of adiponectin in patients with periodontitis were observed in the subgroup analysis of body mass index (BMI) <30. The overall and subgroup analyses showed no significant change in the serum levels of leptin in patients with periodontitis after periodontal treatment. The subgroup analysis of systemically healthy patients showed no significant change in serum levels of adiponectin in patients with periodontitis after periodontal treatment.ConclusionsThe present meta-analysis supported elevated serum levels of leptin and decreased serum levels of adiponectin in patients with periodontitis compared with controls in the BMI <30 population. In systemically healthy patients with periodontitis, serum levels of leptin and adiponectin do not significantly change after periodontal treatment.

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“…P. gingivalis gingipains were shown to reduce the expression of integrins α5 and β1 in a time‐ and dose‐dependent manner in osteoblasts, which could be a reason for increased cell apoptosis 48 . Upregulated osteoblastic apoptosis caused by chronic bacterial infection of periodontal tissues may favor increased osteoblast and bone degradation in patients with MetS 49 . To exclude non‐specific annexin V binding, LDH release in the supernatants was measured, and decreasing cell necrosis was shown over time (Fig.…”

Section: Discussionmentioning

confidence: 99%

Porphyromonas gingivalis Suppresses Differentiation and Increases Apoptosis of Osteoblasts From New Zealand Obese Mice

Dittmann

Doueiri

Kluge

et al. 2015

Journal of Periodontology

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Background: Metabolic syndrome (MetS), a complex cluster of risk factors for chronic diseases such as cardiovascular disease, is observed to be increasingly associated with periodontal disease. However, the fundamental contribution of periodontal bacteria to periodontal bone loss in patients with MetS remains unclear. The aim of the present study is to analyze the effect of Porphyromonas gingivalis on differentiation of primary osteoblasts from New Zealand obese (NZO) mice, a model for MetS, compared with C57 Black 6 JAX (C57BL/6J) mice osteoblasts. Methods: Primary calvarial osteoblasts, isolated from 3‐day‐old NZO and control C57BL/6J mice, were stimulated with P. gingivalis. Proliferation was quantified by 5‐bromo‐2′‐deoxyuridine incorporation. Cell cycle and early and late apoptosis were measured by flow cytometry. Gene expression was determined by real‐time polymerase chain reaction (RT‐PCR). Results: Twelve hours after P. gingivalis stimulation, NZO osteoblasts showed significantly decreased proliferation (P ≤0.01) with increased G2 cell cycle phase compared with normal osteoblasts. Flow cytometry analysis demonstrated significant (P ≤0.01) increase of early apoptotic cells (annexin V positive) and late apoptosis (caspase 3 activity) in NZO cells compared with control cells at 3 and 6 hours after stimulation. No significant lactate dehydrogenase release was found after P. gingivalis stimulation. RT‐PCR data showed significantly suppressed expression (P ≤0.01) of collagen 1, osteocalcin, and Runt‐related transcription factor 2 in NZO cells compared with normal osteoblasts. Conclusions: The present data demonstrate that P. gingivalis downregulates proliferation and promotes apoptosis in primary NZO osteoblasts, unlike C57BL/6J osteoblasts. Also, suppressed osteoblastic marker expression in NZO cells may contribute to pathogenesis of periodontitis, suggesting a similar process in patients with MetS.

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Association of Untreated Metabolic Syndrome With Moderate to Severe Periodontitis in Thai Population

Abstract: There may be a relationship between untreated MetS and periodontitis in Thai people. Periodontal diagnosis should be regularly conducted in patients with MetS.

Cited by 28 publications

References 47 publications

The severity of periodontitis and metabolic syndrome in Korean population: The Dong‐gu study

The severity of periodontitis and metabolic syndrome in Korean population: The Dong‐gu study

Association of circulating leptin and adiponectin with periodontitis: a systematic review and meta-analysis

Porphyromonas gingivalis Suppresses Differentiation and Increases Apoptosis of Osteoblasts From New Zealand Obese Mice

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