Association of type 2 diabetes mellitus and the risk of colorectal cancer: A meta-analysis and systematic review

Guraya, Salman Yousuf

doi:10.3748/wjg.v21.i19.6026

Cited by 142 publications

(133 citation statements)

References 37 publications

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“…Our findings that AIANs with any cancer have a greater proportion of comorbid conditions compared to NHWs are consistent with previous reports using national data sources (28–30) and builds upon these previous reports by using data from an integrated delivery system. We expected that the differences in comorbid conditions between AIANs and NHWs might have explained some of the disparity in cancer survival between AIANs and NHWs.…”

Section: Discussionsupporting

confidence: 92%

Disparities in Prostate, Lung, Breast, and Colorectal Cancer Survival and Comorbidity Status among Urban American Indians and Alaskan Natives

et al. 2017

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Cancer is the second leading cause of death among American Indians and Alaskan Natives (AIAN); although cancer survival information in this population is limited, particularly among urban AIAN. In this retrospective cohort study, we compared all-cause and prostate, breast, lung, and colorectal cancer-specific mortality among AIAN (n=582) and non-Hispanic Whites (NHW) (n=82,696) enrollees of Kaiser Permanente Northern California (KPNC) diagnosed with primary invasive breast, prostate, lung, or colorectal cancer from 1997–2015. Tumor registry and other electronic health records provided information on sociodemographic, comorbidities, tumor, clinical, and treatment characteristics. Cox regression models were used to estimate adjusted survival curves and hazard ratios (HR) with 95% confidence intervals (CI). AIAN had a significantly higher comorbidity burden compared to NHW (p < 0.05). When adjusting for patient, disease characteristics and Charlson comorbidity scores, all-cause mortality and cancer-specific mortality were significantly higher for AIAN than NHW patients with breast cancer (HR= 1.47, 95% CI: 1.13, 1.92) or with prostate cancer (HR = 1.87, 95% CI: 1.14, 3.06) but not for AIAN patients with lung and colorectal cancer. Despite approximately equal access to preventive services and cancer care in this setting, we found higher mortality for AIAN than NHW with some cancers, and a greater proportion of AIAN cancer patients with multiple comorbid conditions. This study provides severely needed information on the cancer experience of the 71% of American Indians/Alaskan Natives who live in urban areas and access cancer care outside of the Indian Health Services, from which the vast majority of AIAN cancer information comes.

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Section: Discussionsupporting

confidence: 92%

Disparities in Prostate, Lung, Breast, and Colorectal Cancer Survival and Comorbidity Status among Urban American Indians and Alaskan Natives

et al. 2017

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“…With each unit increase of the body mass index, the risk for colorectal cancer increases by 2–3% 20 . In close conjunction, patients with type 2 diabetes mellitus also have an increased risk for colorectal cancer 21 . Moderate alcohol consumption (2–3 units per day) has been estimated to increase risk by 20%, whereas even higher alcohol consumption is associated with an up to 50% increased risk 22 .…”

Section: Epidemiologymentioning

confidence: 99%

Colorectal cancer

Kuipers

Grady

Lieberman

et al. 2015

Nat Rev Dis Primers

1,251

1,062

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Colorectal cancer had a low incidence several decades ago. However, it has become a predominant cancer and now accounts for approximately 10% of cancer-related mortality in western countries. The ‘rise’ of colorectal cancer in developed countries can be attributed to the increasingly ageing population, unfavourable modern dietary habits and an increase in risk factors such as smoking, low physical exercise and obesity. New treatments for primary and metastatic colorectal cancer have emerged, providing additional options for patients; these treatments include laparoscopic surgery for primary disease, more-aggressive resection of metastatic disease (such as liver and pulmonary metastases), radiotherapy for rectal cancer and neoadjuvant and palliative chemotherapies. However, these new treatment options have had limited impact on cure rates and long-term survival. For these reasons, and the recognition that colorectal cancer is long preceded by a polypoid precursor, screening programmes have gained momentum. This Primer provides an overview of the current state of art knowledge on the epidemiology and mechanisms of colorectal cancer, as well as on diagnosis and treatment.

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“…Th e yield of screening colonoscopy in this age group is low in available studies ( 136 ), and the biologic reasons for the increasing incidence of CRC in persons under age 50 years are uncertain. Additional study of the benefi ts and harms of screening in persons <50 years is warranted, perhaps particularly in persons with known colorectal risk factors such as cigarette smoking, diabetes mellitus, and obesity (137)(138)(139).…”

Section: Discussionmentioning

confidence: 99%

Colorectal Cancer Screening: Recommendations for Physicians and Patients from the U.S. Multi-Society Task Force on Colorectal Cancer

Rex

Boland

Dominitz

et al. 2017

American Journal of Gastroenterology

519

266

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Association of type 2 diabetes mellitus and the risk of colorectal cancer: A meta-analysis and systematic review

Abstract: Results from this systematic review and meta-analysis report that diabetic people have an increased risk of CRC as compared to non-diabetics.

Cited by 142 publications

References 37 publications

Disparities in Prostate, Lung, Breast, and Colorectal Cancer Survival and Comorbidity Status among Urban American Indians and Alaskan Natives

Disparities in Prostate, Lung, Breast, and Colorectal Cancer Survival and Comorbidity Status among Urban American Indians and Alaskan Natives

Colorectal cancer

Colorectal Cancer Screening: Recommendations for Physicians and Patients from the U.S. Multi-Society Task Force on Colorectal Cancer

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