Association of tumor necrosis factor-α and matrix metalloproteinase-3 gene variants with stroke

Abstract

TNF-α +488 G/A variant is an important risk factor for ischemic stroke in the South Indians from Andhra Pradesh, whereas MMP-3-1612 5A/6A polymorphism is not associated with stroke in the same population.

Association of LPL gene variant and LDL, HDL, VLDL cholesterol and triglyceride levels with ischemic stroke and its subtypes

“…Stroke is a multifactorial disorder influenced by genetic and environmental factors [1][2][3][4][5][6][7][8]. Evidence suggests that variations in the lipoprotein lipase gene may influence stroke risk [9].…”

Systematic Review by Multivariate Meta-analyses on the Possible Role of Tumor Necrosis Factor-α Gene Polymorphisms in Association with Ischemic Stroke

“…Figure 1 shows the results of literature search and selection. A total of 186 articles were retrieved with the comprehensive literature search, and finally 25 articles (Bai and Cheng 2004;Balding et al 2004;Lee et al 2004;Um and Kim 2004;Karahan et al 2005;Rubattu et al 2005;Harcos et al 2006;Lalouschek et al 2006;Llamas Sillero et al 2007;Zhang et al 2007;Liu et al 2009Liu et al , 2012Shi et al 2009;Kim et al 2010;Tong et al 2010;Markoula et al 2011;Munshi et al 2011;Sultana et al 2011;Szabo and Acsady 2011;Wu et al 2011;Cui et al 2012;Tuttolomondo et al 2012;Gelfand et al 2013;Ma 2012) (18 in English and seven in Chinese) of them were included in the present study according to the eligible criteria. Forty-nine eligible case-control studies from these 25 articles involve 23 studies of -308G/A (6220 patients and 6531 controls), 14 studies of -238G/A (4760 patients and 4389 controls), four studies of -857C/T (2589 patients and 2097 controls), three studies of -1031T/C (2416 patients and 1948 controls), one study (404 patients and 415 controls) of -244G/ A and -367G/A, one study (67 patients and 70 controls) of -646G/A, -806C/T, -863C/A, and one study (525 patients and 500 controls) of ?448G/A.…”

Genetics of ischemic stroke: Indian perspective

“…[41] Recently, we analyzed +488 G/A polymorphism in TNF-α gene and found a significant association of this polymorphism with ischemic stroke risk in the south Indian population from Andhra Pradesh, especially intracranial large artery atherosclerosis, extracranial large artery, atherosclerosis, cardio embolism, and stroke of undetermined etiology. [38] However, a study carried out by Banerjee et al in the north Indian population on 308 G/A polymorphism of TNF-α could not establish an association with ischemic stroke. [42] A recent case-control study carried out by Chakraborty et al on IL-6 -174 G/C polymorphism, in association with severity and outcome in acute ischemic stroke patients from North India reported that the patients with the GC genotype had more severe strokes with poorer short and long-term outcomes and increased mortality but GG genotype appears to be protective against stroke severity, outcome, and mortality.…”

“…[37] We evaluated the MMP-3 5A/6A polymorphism in the South Indian population but we did not find a significant association. [38] Genes Involved in Inflammation Pathway Accumulated evidence suggests important roles for inflammation in the process of atherosclerosis and specifically in stroke. Clinical and experimental evidence implicates inflammation in multiple phases of stroke etiology and pathology.…”