Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia

Romero-Sánchez, Consuelo; Londoño, Jhon; Delgado, G.; Jaimes, Diego; Ávila, Juliette De; Mora, Adria Suarez; Ávila, Mabel; Castellanos, Jaime E.; Briceño, Ignacio; Valle-Oñate, Rafael

doi:10.1007/s00296-011-1883-1

Cited by 17 publications

(9 citation statements)

References 7 publications

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“…Our analysis showed that the TNF -308 GA/AA genotype was associated with the development of overall SpA and AS, independent of gender and HLA-B27 allelic group. This finding is in agreement with that of Höhler et al who demonstrated an association of the TNF -308 A/A genotype with AS in German patients [ 29 ] and that of Romero-Sánchez et al who showed that the A allele frequency of TNF -308 was increased in Columbian patients with SpA, AS, and rheumatoid arthritis [ 30 ]. This suggests that TNF -308A could be a susceptibility factor for this disease.…”

Section: Discussionsupporting

confidence: 92%

Influence of TNF and IL17 Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population

Loures

Macedo

Reis

et al. 2018

Mediators of Inflammation

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Background and Objectives Spondyloarthritis (SpA) represents a heterogeneous group of immune-mediated inflammatory diseases that have overlapping clinical features, genetic predisposition, and pathogenic mechanisms. Hence, we investigated, through a case-control study, whether single-nucleotide polymorphisms of TNF and IL17 genes are associated with SpA, ankylosing spondylitis (AS), and psoriatic arthritis (PsA) in a mixed Brazilian population. Methods Genotyping of TNF-308 (rs1800629), TNF-238 (rs361525), IL17A (rs2275913), IL17F (rs763780), and HLA-B27 polymorphisms was performed in 243 patients with SpA and 210 controls from Southern Brazil using SSOP-Luminex (One Lambda) and PCR-SSP assays. Results Significant associations were confirmed between the HLA-B27 marker and SpA, AS, and PsA diseases. While TNF-308 (rs1800629) AA/GA, IL17A (rs2275913) AA/GA, and IL17F (rs763780) CC/TC genotype frequencies were associated, in the dominance inheritance model, with SpA and AS, regardless of gender, the presence of HLA-B27, TNF-238 (rs361525) GA/AA, IL17A (rs2275913) AA/GA, and IL17F (rs763780) genotypes was associated with PsA. Conclusion In this Brazilian population, TNF and IL17 gene polymorphisms responsible for the expression of important inflammatory cytokines were associated with overall SpA, and, specifically, with AS and PsA, regardless of gender and HLA-B27. However, future larger studies with different ethnicities may be necessary to confirm these genetic associations.

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Section: Discussionsupporting

confidence: 92%

Influence of TNF and IL17 Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population

Loures

Macedo

Reis

et al. 2018

Mediators of Inflammation

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“…The TNF-a protein is a potent proinflammatory cytokine and immune modulator of joint destruction, and TNF-a possibly should be considered as a risk factor for the development of SpA and IBD [11]. TNF-a stimulates the expression of adhesion molecules and increases neutrophil activation.…”

Section: Discussionmentioning

confidence: 99%

“…and severity of SpA and IBD, as well as the response of anti-TNF treatment [3,[9][10][11][12][13][14][15][16][17][18][19][20][21]. Among the SNPs, there are two common polymorphisms that have been studied extensively.…”

Section: Research Articlementioning

confidence: 99%

Association of TNF- α Polymorphism with Prediction of Response to TNF Blockers in Spondyloarthritis and Inflammatory Bowel Disease: A Meta-Analysis

et al. 2013

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“…Three single nucleotide polymorphisms (SNPs) in genes that encode inflammatory cytokines have been associated with AS, in a previous study by our research group (TNF rs1800629, IL17A rs2275913, and IL17F rs763780) (6). These polymorphisms can interfere with the level of production of these cytokines and contribute to the development of AS (7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 95%

Influence of IL10 (rs1800896) Polymorphism and TNF-α, IL-10, IL-17A, and IL-17F Serum Levels in Ankylosing Spondylitis

et al. 2021

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Ankylosing spondylitis (AS) is a chronic autoimmune inflammatory disease that mainly affects the axial and sacroiliac joints. Single-nucleotide polymorphisms (SNPs) in genes encoding cytokines have been associated with AS, which can interfere with the production of these cytokines and contribute to the development of AS. In order to contribute to a better understanding of the pathology of AS, our objective was to investigate a possible association of the IL10 −1082 A>G SNP (rs1800896) with AS and to evaluate the serum levels of TNF-α, IL-10, IL-17A, and IL-17F in AS patients and controls comparing them with their respective genotypes (TNF rs1800629, IL10 rs1800896, IL17A rs2275913, and IL17F rs763780). Patients and controls were selected from the Maringá University Hospital and the Maringá Rheumatism Clinic, in Paraná State, Southern Brazil, and they were diagnosed by the ASAS Criteria. In total, 149 patients and 169 controls were genotyped for the IL10 −1082 A>G polymorphism using a polymerase chain reaction with sequence specific primers (PCR-SSP); the measurement of TNF-α serum levels was performed through the immunofluorimetric test and IL-10, IL-17A, and IL-17F using an ELISA test. There was a high frequency of the IL10 −1082 G allele in AS patients compared with controls with an odds ratio of 1.83 and 95% confidence interval of 1.32 to 2.54, and a significant difference in the genotype frequencies of the IL10 −1082 A/G+G/G between patients and healthy controls, with an odds ratio of 3.01 and 95% confidence interval of 1.75 to 5.17. In addition, increased serum levels of IL-10 were observed in AS patients: 2.38 (IQR, 0.91) pg/ml compared with controls 1.72 (IQR 0.93) pg/ml (P = 0.01). Our results also showed an association between IL17F rs763780 C/T+T/T genotypes and increased serum levels of IL-17F in patients with AS and also in controls. We can conclude that patients with the A/G and G/G genotypes for −1082 A>G (rs1800896) in the IL10 gene are three times more likely to develop AS, that the serum level of IL-10 was higher in AS patients and that the IL17F rs763780 polymorphism can affect the levels of IL-17F in the serum of patients and controls in the same way.

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Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia

Cited by 17 publications

References 7 publications

Influence of TNF and IL17 Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population

Influence of TNF and IL17 Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population

Association of TNF- α Polymorphism with Prediction of Response to TNF Blockers in Spondyloarthritis and Inflammatory Bowel Disease: A Meta-Analysis

Influence of IL10 (rs1800896) Polymorphism and TNF-α, IL-10, IL-17A, and IL-17F Serum Levels in Ankylosing Spondylitis

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