Association of tumor necrosis factor α −308G/A and interleukin-6 −174G/C gene polymorphism with pneumonia-induced sepsis

Feng, Bo; Mao, Zhengrong; Pang, K. Sandy; Zhang, Shaolei; Li, Li

doi:10.1016/j.jcrc.2015.04.123

Cited by 36 publications

(37 citation statements)

References 40 publications

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“…The influence of IL-6 promoter polymorphism (-174 G/C) on sepsis risk and sepsis mortality has been addressed in some studies [18,19,20,21,22,23,24,25,26,27,28,29]. A recently published meta-analysis found no association between IL-6 promoter polymorphism (-174 G/C) and sepsis-related mortality [30].…”

Section: Discussionmentioning

confidence: 99%

“…A recently published meta-analysis found no association between IL-6 promoter polymorphism (-174 G/C) and sepsis-related mortality [30]. In addition, another two studies were published after the meta-analysis [18,19]. In children with community-acquired pneumonia (CAP), Zidan et al found that patients with genotype GG showed a lower risk of early mortality [19].…”

Section: Discussionmentioning

confidence: 99%

“…In children with community-acquired pneumonia (CAP), Zidan et al found that patients with genotype GG showed a lower risk of early mortality [19]. In 277 Chinese patients with severe pneumonia-induced sepsis, Feng et al found no association between IL-6 promoter polymorphism (-174 G/C) and mortality [18]. Most previous studies had a small sample size (fewer than 200 patients) and circulating levels of IL-6 were not reported.…”

Section: Discussionmentioning

confidence: 99%

“…Most previous studies had a small sample size (fewer than 200 patients) and circulating levels of IL-6 were not reported. Only three studies had a sample size higher than 200 patients (277, 306 and 1135 patients, respectively) [18,22,23]. Rodriguez-Gallego et al did not find an association between that polymorphism and mortality in patients with CAP [23]; and in another study, the same team found that pneumococcal CAP patients with genotype GG had a lower risk of death [22].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, an association between IL-6 promoter polymorphism (-174 G/C) and circulating IL-6 levels has been found in different diseases [11,12,13,14,15,16,17]. The influence of IL-6 promoter polymorphism (-174 G/C) on sepsis risk and sepsis-related mortality has been addressed in some studies [18,19,20,21,22,23,24,25,26,27,28,29], but a recently published meta-analysis found no association between this polymorphism and sepsis-related mortality [30]. However, in most of those studies the sample size was small and circulating levels of IL-6 were not reported.…”

Section: Introductionmentioning

confidence: 99%

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Association between Interleukin-6 Promoter Polymorphism (-174 G/C), Serum Interleukin-6 Levels and Mortality in Severe Septic Patients

Lorente

Martı́n

Pérez-Cejas

et al. 2016

IJMS

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The association between interleukin (IL)-6 promoter polymorphism (-174 G/C), circulating IL-6 levels and mortality in septic patients has scarcely been addressed, and then only in studies of small sample size, and a direct association among them has not been previously reported. Therefore, the purpose of our study was to determine whether this association exists. An observational, prospective and multicenter study including severe septic patients was undertaken and serum IL-6 levels at severe sepsis diagnosis and IL-6 promoter polymorphism (-174 G/C) were determined. The end-point of the study was 30-day mortality. The study included 263 patients with the following genotypes of IL-6 promoter polymorphism (-174 G/C): 123 (46.8%) GG, 110 (41.8%) GC and 30 (11.4%) CC. CC homozygous patients showed lower sepsis-related organ failure assessment (SOFA) score, serum IL-6 levels and mortality at 30 days compared to those with other genotypes (GC or GG). On regression analysis, CC homozygous patients showed lower 30-day mortality than those with genotype GG (odds ratio = 0.21; 95% CI = 0.053−0.838; p = 0.03) or GC (hazard ratio = 0.28; 95% CI = 0.074−1.037; p = 0.06). The most important results of our study were that CC might be a favorable genotype in septic patients showing lower serum IL-6 levels and lower risk of death within 30 days.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Association between Interleukin-6 Promoter Polymorphism (-174 G/C), Serum Interleukin-6 Levels and Mortality in Severe Septic Patients

Lorente

Martı́n

Pérez-Cejas

et al. 2016

IJMS

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Single nucleotide polymorphisms located in TNFA, IL1RN, IL6R, and IL6 genes are associated with COVID‐19 risk and severity in an Iranian population

Rokni

Sarhadi

Nia

et al. 2022

Cell Biology International

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Cytokines play pivotal functions in coronavirus disease 2019 pathogenesis. However, little is known about the rationale and importance of genetic variations associated with immune system responses, so-called "immunogenetic profiling." We studied whether polymorphisms of IL6, IL6R, TNFA, and IL1RN affect the disorder severity and outcome in patients infected with COVID19. We recruited 317 hospitalized patients with laboratory-confirmed COVID-19 from Bu-Ali hospital and 317 high-risk participants who had high exposure to COVID-19 patients but with a negative real-time-polymerase chain reaction (PCR) test. Multiple regression analyses were applied. We indicated that participants carrying the A allele in TNFA-rs361525, G>A (p < .004), the C allele in IL1RN-rs419598 T>C (p < .004), the A allele in IL6R-rs2228145, A>C (p = .047) are more susceptible to develop COVID-19. In contrast, those who carry the G allele of IL6-rs2069827, G>T (p = .01), are more protected from COVID-19. Also, we compared the various genotypes regarding the disorder severity and poor prognosis; we found that the AA genotype in TNFA is related to more aggressive illness and bad prognostic in contrast to the other inflammatory cytokines' genotypes. In addition, a high level of inflammatory indications, such as neutrophil-to-lymphocyte ratio and systemic immuneinflammation index, was observed in deceased patients compared with the survived subjects (p < .0001). We advised considering inflammatory cytokines polymorphisms as the main item to realize the therapeutic response against the acute respiratory distress syndrome induced by the SARS-CoV-2 virus.

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Variants in TNF and NOS3 (eNOS) genes associated with sepsis in adult patients

Özkan

Günay

Şener

et al. 2021

The Journal of Gene Medicine

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Background Sepsis is a life‐threatening condition caused by a dysregulated host response to infections and is a leading cause of death in hospitalized patients. The present study aimed to elucidate the possible association between sepsis and the tumor necrosis factor (TNF) gene –308G/A (rs1800629) polymorphism, as well as endothelial nitric oxide synthase (eNOS, NOS3) gene –786T/C (rs2070744), 4a/4b (27 bp‐VNTR in intron 4, rs61722009) and 894G/T (Glu298Asp, rs1799983) polymorphisms. Methods In total, 188 septic adult cases and 188 healthy controls were enrolled. Genomic DNAs from the controls and patients were analyzed by polymerase chain reaction and restriction fragment length polymorphism methods. Results There were significant associations between the G/G genotype and G allele of the TNF –308G/A (rs1800629) polymorphism in the sepsis group (p < 0.001). The presence of the T/C genotype (p = 0.002) and C allele (p = 0.001) of the –786T/C (rs2070744) was markedly associated with an increased risk of sepsis. However, no significant associations were found with 4a/4b (27 bp‐VNTR in intron 4, rs61722009) and 894G/T (Glu298Asp, rs1799983) polymorphisms. Higher 4bGC and lower 4bTT haplotype frequencies were associated with sepsis. Conclusions Our results strongly suggest that TNF gene (−308G/A, rs1800629) and NOS3 gene –786T/C (rs2070744) polymorphisms may modify individual susceptibility to sepsis in the Turkish population.

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Association of tumor necrosis factor α −308G/A and interleukin-6 −174G/C gene polymorphism with pneumonia-induced sepsis

Cited by 36 publications

References 40 publications

Association between Interleukin-6 Promoter Polymorphism (-174 G/C), Serum Interleukin-6 Levels and Mortality in Severe Septic Patients

Association between Interleukin-6 Promoter Polymorphism (-174 G/C), Serum Interleukin-6 Levels and Mortality in Severe Septic Patients

Single nucleotide polymorphisms located in TNFA, IL1RN, IL6R, and IL6 genes are associated with COVID‐19 risk and severity in an Iranian population

Variants in TNF and NOS3 (eNOS) genes associated with sepsis in adult patients

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