Association of Tuberculosis and M. tuberculosis-Specific Antibody Levels with HLA

Bothamley, Graham; Beck, John S.; Schreuder, G. M. T.; D'Amaro, J; Vries, R. R. P. De; Kardjito, T.; Iványi, Juraj

doi:10.1093/infdis/159.3.549

Cited by 157 publications

(81 citation statements)

References 29 publications

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“…In the Tb patients, the reactivity frequency (60%) observed for this protein was similar to that observed by others [32]. Its strong association with HLA antigens [33], and its relation with the presence of cavitary [34] processes, explains the variation in sensitivity values reported by different investigators, which depends on the population under investigation. For the antigens in the 16 kDa range, we found 50% reactivity.…”

Section: Discussionsupporting

confidence: 84%

Combined use of Western blot/ELISA to improve the serological diagnosis of human tuberculosis

Beck¹,

Leite²,

Arruda³

et al. 2005

Braz J Infect Dis

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Two recombinant antigens and a crude bacterial antigen of a wild M. tuberculosis strain were used to detect specific IgG antibodies in sera from 52 patients with pulmonary tuberculosis, confirmed by an acid-fast smear and serum culture of these patients and that of 25 contacts. The patients were not infected with HIV. We evaluated the sensitivity and specificity of ELISA, based on the recombinant TbF6® ® ® ® ® and TbF6/DPEP antigen and a search for reactivity patterns in the Western blot technique, using whole mycobacterium antigen. Serum samples from 22 healthy individuals and from 30 patients with lung diseases other than tuberculosis were used as controls. The best ELISA results were obtained with the TbF6/DPEP antigen combination, which gave 85% sensitivity and 91% specificity. ELISA sensitivity improved from 85% to 92% when the Western blot results were used. Western blot specificity was 100% when antibody reactivity with different antigenic bands was analyzed and associated. The association of TbF6/DPEP antigens used in ELISA with specific patterns of reactivity determined by Western blot can help make an identification when classic methods for the diagnosis of pulmonary tuberculosis are not sufficient.

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Section: Discussionsupporting

confidence: 84%

Combined use of Western blot/ELISA to improve the serological diagnosis of human tuberculosis

Beck¹,

Leite²,

Arruda³

et al. 2005

Braz J Infect Dis

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“…[125][126][127][128] However, there is evidence for heterogeneity as not all populations studied demonstrate the HLA-DR2 effect. 129 A more recent study of patients and controls from Cambodia found an association between HLA-DQB1*0503 and tuberculosis, and this needs investigation in other populations.…”

Section: Major Histocompatibility Complexmentioning

confidence: 99%

Susceptibility to mycobacterial infections: the importance of host genetics

2003

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There is substantial evidence that host genetic factors are important in determining susceptibility to mycobacteria. Several different techniques have been used to identify the genes involved. Studies of an inbred strain of mice with increased susceptibility to mycobacteria, salmonella and leishmania infections led to the identification of the natural resistance-associated macrophage protein gene (Nramp1). Case-control studies have confirmed the importance of the human equivalent of this gene, NRAMP1, and have also suggested that the major histocompatibility complex and vitamin-D receptor genes may be involved in determining human susceptibility to mycobacteria. Studies of individuals with the rare condition of increased susceptibility to disseminated bacille Calmette-Guerin and other atypical mycobacterial infections have identified several abnormalities in the genes encoding the interferon gamma receptor (IFNgR) ligand binding chain, IFNgR signal transduction chain, IFNg signal transduction and activation of transcription-1, interleukin 12 receptor b1 subunit and interleukin 12 p40 subunit. A genome-wide linkage study has been performed to identify genes exerting a major effect on tuberculosis susceptibility in the general population. Linkages were found to markers on chromosomes 15 and X. Studies to identify the genes responsible are in progress.

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“…Human Leucocyte Antigen (HLA) genes are implicated in the spectral clinical manifestations characteristic of both tuberculosis and leprosy [119]. The limited data obtained may indicate an association of HLA-DR2 and pulmonary tuberculosis [120,121]. In mice, H-2 linked genes are known to control both granulomatous responses and resistance to M. lepramurium [122].…”

Section: Genetic Factors In Resistance To Tuberculosismentioning

confidence: 99%

Host Responses and Antigens Involved in Protective Immunity to Mycobacterium tuberculosis

1997

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Andersen P. Host Responses and Antigens Involved in Protective Immunity to Mycobacterium tuberculosis. Scand J Immunol 1997;45:115-131 Tuberculosis (TB) is the largest single infectious cause of human mortality. The incidence of TB has remained high in most of the developing world and the disease has recently re-emerged as a public health problem in industrialized countries. The development of a new improved TB vaccine is a highly prioritized international research area, which has been further stimulated by the appearance of multi-drug resistant strains of Mycobacterium tuberculosis. The present status of the attempts to characterize the protective immune response to TB will be reviewed with special emphasis on recent progress in the identification and characterization of target molecules recognized by protective cells. This paper will focus on proteins released from live bacteria and discuss their role in the host-pathogen interaction and the ongoing attempts to use these molecules in TB subunit vaccines.

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Association of Tuberculosis and M. tuberculosis-Specific Antibody Levels with HLA

Cited by 157 publications

References 29 publications

Combined use of Western blot/ELISA to improve the serological diagnosis of human tuberculosis

Combined use of Western blot/ELISA to improve the serological diagnosis of human tuberculosis

Susceptibility to mycobacterial infections: the importance of host genetics

Host Responses and Antigens Involved in Protective Immunity to Mycobacterium tuberculosis

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