Association of Treatment With Antipsychotics, Antidepressants, or Both With Movement Disorders and Seizures Among Children and Adolescents With Depression in Korea

Abstract

Key Points Question Is treatment with antipsychotics in children and adolescents who are taking antidepressant medications associated with neurological adverse events? Findings In this cohort study of 9890 children and adolescents prescribed antidepressants for depression, the hazard ratios of movement disorders and seizures with adjuvant antipsychotics were 2- to 3-fold higher compared with antidepressant monotherapy. Hazard ratios increased with increasing doses of adjuvant antipsychotics and varied according to which antipsychotic was concomitantly used. Meaning These results suggest that adjuvant use of antipsychotics needs to be carefully considered in the treatment children and adolescents with depression.

Dose-Dependent Biphasic Action of Quetiapine on AMPK Signalling via 5-HT7 Receptor: Exploring Pathophysiology of Clinical and Adverse Effects of Quetiapine

“…The high seizure risk during QTP treatment is well known [ 82 , 83 ], whereas, contrary to clozapine [ 84 ], the dose dependence of the seizure risk of QTP remains to be clarified. For QTP-induced seizure, the timing appears to range from several hours to one day after the supratherapeutic dose of QTP is administered [ 85 , 86 , 87 ].…”

GL-II-73, a Positive Allosteric Modulator of α5GABAA Receptors, Reverses Dopamine System Dysfunction Associated with Pilocarpine-Induced Temporal Lobe Epilepsy

“…Antipsychotic medications incompletely treat psychosis symptoms and are associated with substantial adverse effects [9]. Additionally, there is evidence to suggest that antipsychotics can lower seizure threshold and increase seizure incidence [7,8], and undergo potential pharmacokinetic and pharmacodynamic interactions with antiepileptic drugs [7]. Thus, there is an immediate need for novel therapeutics to treat psychosis in TLE patients.…”

“…TLE patients are 6-12 times more likely than the general population to suffer from psychosis [5,6]; however, the management of psychosis for patients with TLE is currently inadequate. Both firstand second-generation antipsychotics are associated with an increase in seizure incidence, as they can lower seizure thresholds [7,8]. Additionally, antipsychotics often produce intolerable side effects that lead to the discontinuation of medication [9], and have potential pharmacokinetic and pharmacodynamic interactions with antiepileptic drugs [7].…”