Association of traumatic stress and posttraumatic stress disorder with carotid atherosclerosis: findings from the general population

Spitzer, Carsten; Klinger-König, Johanna; Frenzel, Stefan; Schminke, Ulf; Völzke, Henry; Lübke, Laura; Grabe, Hans J.

doi:10.1080/20008198.2020.1815280

Cited by 9 publications

(6 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For IMT, some studies have reported that PTSD is associated with higher IMT, yet findings are mixed and focused on male veterans or specific populations (eg, adults experiencing deportation). 42,43 Some studies have indicated associations of PTSD symptoms with WMH 44 and cognition, 45 yet these studies relied on data from males, veterans, and/or individuals undergoing PTSD treatment. The NHS II of midlife women found that women with histories of trauma exposure and more PTSD symptoms had greater declines in cognitive performance over approximately 1 year compared with women without PTSD symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…Some prior studies, largely focused on men and/or veterans, have considered PTSD symptoms in relation to cardiovascular or brain health. For IMT, some studies have reported that PTSD is associated with higher IMT, yet findings are mixed and focused on male veterans or specific populations (eg, adults experiencing deportation) . Some studies have indicated associations of PTSD symptoms with WMH and cognition, yet these studies relied on data from males, veterans, and/or individuals undergoing PTSD treatment.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Posttraumatic Stress Disorder Symptoms and Cardiovascular and Brain Health in Women

Thurston,

Jakubowski,

Chang

et al. 2023

JAMA Netw Open

View full text Add to dashboard Cite

ImportancePosttraumatic stress disorder (PTSD), cardiovascular disease (CVD), and Alzheimer disease are major public health issues, particularly for women. The implications of PTSD for cardiovascular and brain health for women is poorly understood.ObjectiveTo assess whether PTSD symptoms among midlife women are associated with carotid intima media thickness (IMT), an indicator of carotid atherosclerosis; brain white matter hyperintensity volume (WMHV), an indicator of brain small vessel disease; and cognitive performance and to test a modifying role of the APOEε4 genotype.Design, Setting, and ParticipantsIn this cross-sectional study, participants were enrolled between 2016 to 2021 and completed questionnaires (PTSD Checklist–Civilian Version), physical measures, phlebotomy, neuropsychological testing, a carotid ultrasonographic examination, and 3-Tesla brain magnetic resonance imaging. Participants included community-based women ages 45 to 67 years without a history of CVD, stroke, or dementia. Data were analyzed from July 2022 to September 2023.ExposuresPTSD symptoms.Main Outcomes and MeasuresOutcomes of interest were associations of PTSD symptoms with carotid IMT, brain WMHV, and cognition, assessed in linear regression models. Interactions by APOEε4 were tested. Covariates included age, race and ethnicity, education, and CVD risk factors.ResultsAmong 274 participants (mean [SD] age, 59.03 [4.34] years; 6 Asian participants [2.2%]; 48 Black participants [17.5%]; 215 White participants [78.5%]; 5 multiracial participants [1.8%]), 64 participants (24.71%) were APOEε4 genotype carriers. Higher PTSD symptoms were associated with greater carotid IMT (multivariable β = 0.07 [95% CI, 0.01 to 0.13]; P = .03). Associations of PTSD symptoms with neurocognitive outcomes significantly varied by APOEε4 status. Among women with APOEε4, PTSD symptoms were associated with greater whole-brain WMHV (β = 0.96 [95% CI, 0.30 to 1.63]; P = .009), periventricular WMHV (β = 0.90 [95% CI, 0.24 to 1.56]; P = .02), deep WMHV (β = 1.21 [95% CI, 0.23 to 2.20]; P = .01), and frontal WMHV (β = 1.25 [95% CI, 0.05 to 2.45]; P = .04), as well as with poorer cognition, specifically attention and working memory (β = −3.37 [95% CI, −6.12 to −0.62]; P = .02), semantic fluency (β = −6.01 [95% CI, −10.70 to −1.31]; P = .01), perceptual speed (β = −12.73 [95% CI, −20.71 to −4.75]; P = .002), and processing speed (β = −11.05 [95% CI, −17.80 to −4.30]; P = .002) in multivariable models.Conclusions and RelevanceIn this cross-sectional study of midlife women, greater PTSD symptoms were associated with higher carotid atherosclerosis and, among women who were APOEε4 carriers, greater brain small vessel disease and poorer cognitive performance. These findings point to the adverse implications of PTSD symptoms for cardiovascular and neurocognitive health among women in midlife, particularly for women who are APOEε4 carriers.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Posttraumatic Stress Disorder Symptoms and Cardiovascular and Brain Health in Women

Thurston,

Jakubowski,

Chang

et al. 2023

JAMA Netw Open

View full text Add to dashboard Cite

show abstract

“…La actividad formativa y sus beneficios pueden abordarse como un valor afirmativo; los participantes egresados perciben que pueden tomar acciones cuando se requiere atender población en situación de trauma para contribuir activamente a la salud y el bienestar de las personas que atienden, lo que representa un efecto positivo considerando los problemas de salud asociados (Cavalcanti-Ribeiro et al, 2012;Cougle et al, 2009;Klest et al, 2013;Spitzer et al, 2020) y la grave interferencia en la vida cotidiana que se ha reportado (Adams et al, 2016;Bishop et al, 2017;McElroy et al, 2016). Los proveedores de atención para la salud y de atención de primera línea, necesitan implementar prácticas basadas en evidencia con sus pacientes a lo largo de un continuo de atención en diversos entornos (como hospitales y cuidados a largo plazo).…”

Section: Discussionunclassified

“…De manera más específica, los acontecimientos traumáticos han sido vinculados como un factor contribuyente para el desarrollo de problemas psiquiátricos, incluido el trastorno por estrés postraumático (TEPT), trastorno por estrés agudo (TEA), síntomas de disociación, depresión, abuso de sustancias, tendencias suicidas y conductas autolesivas, por mencionar las principales. También se le ha relacionado con problemas de salud física, como problemas isquémicos y conductas negativas para la salud, como fumar y obesidad (Cougle, Resnick y Kilpatrick, 2009;Klest, Freyd, Hampson y Dubanoski, 2013;Spitzer et al, 2020). Los efectos del trauma pueden incluir trastornos de la personalidad, relaciones interpersonales deterioradas, mal funcionamiento ocupacional y disminución de la calidad de vida (Cavalcanti-Ribeiro et al, 2012).…”

unclassified

Evaluación de un Programa de Enseñanza en Línea para la Identificación y el Tratamiento del Trastorno por Estrés Postraumático

Cárdenas-López¹,

González-Perellón²,

Durón-Figueroa³

2022

RDIPyCS

View full text Add to dashboard Cite

El Trastorno por Estrés Postraumático se caracteriza por un conjunto de síntomas que aparecen después de la exposición a uno o varios acontecimientos amenazantes hacia la propia vida e integridad del individuo. A pesar de que existen tratamientos especializados basados en evidencia, se han identificado algunas limitaciones en cuanto a la capacitación de profesionales de la salud mental para el manejo terapéutico adecuado. El objetivo de este estudio fue evaluar el impacto de un programa en línea para la identificación y tratamiento del trastorno por estrés postraumático y trastornos asociados, con el propósito de obtener información relevante sobre los efectos en la práctica clínica del curso y diplomado impartidos. El estudio evaluó a 167 participantes graduados después de seis meses de finalizar el programa. La evaluación fue sobre su desempeño en la identificación y atención de pacientes expuestos a trauma. Los resultados muestran un impacto positivo del programa en los planes de detección, diagnóstico y tratamiento implementados por los participantes. La evaluación del entrenamiento refiere información relevante sobre los efectos del programa de formación para poder reflexionar, analizar y mejorar su eficacia y eficiencia.

show abstract

“…Atherosclerosis and carotid plaques 19 [21,13,14,140,142,147,17,149,139,136,125,141,151,155,22,123,118] Arterial stiffness 3 [113,129,138] Arterial thickness 14 [135,148,137,114,115,133,124,119,144,126,121,130,156,153,122] Nonspecific cardiovascular risk factors 12 [146,112,114,115,145,131,116,150,120,143,134,127] Organ damage 1 [128] Not reported 1 [154] Technique Ultrasound 49…”

Section: Vascular Bed Assessedmentioning

confidence: 99%

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

et al. 2023

View full text Add to dashboard Cite

Research involving human subjects in ambulatory settings is a critical link in the chain comprising translational research, spanning preclinical research to human subject and patient cohort studies. There are presently a wide array of techniques and approaches available to investigators wishing to study blood flow, perfusion, and vascular structure and function in human subjects. In this multi-sectioned review, we discuss capillaroscopy, carotid intima-media thickness, flow-mediated dilation, laser Doppler flowmetry, near-infrared spectroscopy, peripheral arterial tonometry, pulse wave velocity, retinal fundus imaging, and vascular plethysmography. Each section contains a general overview and the physical basis of the technique followed by a discussion of the procedures involved and the necessary equipment, with attention paid to specific requirements or limitations. Subsequently, we detail which aspects of vascular function can be studied with a given technique, the analytical approach to the collected data, and the appropriate application and limitation(s) to the interpretation of the data collected. Finally, a modified scoping review provides a summary of how each assessment technique has been applied in previous studies. It is anticipated that this review will provide an efficient source of information and insight for preclinical investigators seeking to add translational aspects to their research programs.

show abstract

Association of traumatic stress and posttraumatic stress disorder with carotid atherosclerosis: findings from the general population

Cited by 9 publications

References 51 publications

Posttraumatic Stress Disorder Symptoms and Cardiovascular and Brain Health in Women

Posttraumatic Stress Disorder Symptoms and Cardiovascular and Brain Health in Women

Evaluación de un Programa de Enseñanza en Línea para la Identificación y el Tratamiento del Trastorno por Estrés Postraumático

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

Contact Info

Product

Resources

About