Association of transforming growth factor-<b>β</b>1 polymorphisms with the risk of chronic kidney diseases

Mao, Song; Yan, Bin; Zhang, Jianhua

doi:10.3109/0886022x.2015.1077324

Cited by 9 publications

(9 citation statements)

References 30 publications

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“…In our study, the TGF-β1 869 T > C variant genotype was present in 87.40% of mothers and in 79.90% of newborns. We also identified in our study that newborns with heterozygous or variant homozygous genotype (TC + CC) have a higher obesity risk, similar to the study of Mao, who showed that the CC genotype of the TGF-β1 869 T > C gene is associated with type 2 diabetes mellitus, thus representing a risk factor, [53] and also with Rodrigues’ study who pointed out that the CC genotype in patients with BMI under 25 kg/m 2 and TC genotype of the TGF-β1 869 T > C polymorphism in patients with BMI of 30 kg/m 2 are associated with type 2 diabetes mellitus. [54] …”

Section: Discussionsupporting

confidence: 88%

The role of TGF-β1 869 T > C and PPAR γ2 34 C > G polymorphisms, fat mass, and anthropometric characteristics in predicting childhood obesity at birth

Mărginean

Iancu²,

Szabó

et al. 2016

Medicine

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This study proposed to establish a correlation between the risk score for child obesity and anthropometric, genetic, and bioimpedance characteristics in mothers and newborns, and to assess the discriminant ability for anthropometric parameters to classify over-fatness (defined by bioimpedance body fatness %) in pregnant women.We performed a cross-sectional study on 388 couples (mother and father) and their newborns admitted in a Tertiary Hospital from Romania. The measured parameters for mothers and their newborns were risk percentage for child obesity, anthropometric characteristics (mid-upper arm circumference [MUAC], tricipital skinfold thickness [TST] of mother and newborn), genetic polymorphisms (human peroxisome proliferator-activated receptor γ [PPARγ2] 34 C > G and transforming growth factor-beta 1 [TGF-β1] 869 T > C gene polymorphisms in both mothers and newborns), and mother's bioimpedance characteristics (fat mass [FM] %).The obesity risk score according to standard predictable Northern Finland Birth Cohort equation was in our study 4.07%. We found a monotone positive significant correlation between the newborn's risk of childhood obesity and the mother's TST (P = 0.01), as well as a tendency toward statistical significance concerning correlation with mother's MUAC (P = 0.053), without any correlations with the mothers’ bioimpedance parameters and also a positive correlation between the newborn's risk of childhood obesity and the newborn's anthropometrical characteristics like body mass index (BMI), MUAC, and TST (P < 0.001). We observed that the calculated newborn's risk percentage for child obesity was greater for the variant allele of the TGF-β1 869 T > C polymorphism and also for the wild-type C allele of the PPARγ2 34 C > G gene polymorphism. Our study indicated that the best predictors for over-fatness are BMI and MUAC (P = 0.01 < 0.02 and P = 0.019 < 0.02, respectively).

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Section: Discussionsupporting

confidence: 88%

The role of TGF-β1 869 T > C and PPAR γ2 34 C > G polymorphisms, fat mass, and anthropometric characteristics in predicting childhood obesity at birth

Mărginean

Iancu²,

Szabó

et al. 2016

Medicine

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“…Khalil et al found that among patients with CKD of different origin, there was an association between SNP rs1800471 and rapid progression of CKD (Khalil et al, 2005). A previous meta-analysis by Mao et al evaluating the relation of TGF-b1 polymorphisms with CKD susceptibility reported similar findings for rs1800469 and rs1800470 (Mao et al, 2015). However, they did not find any association of rs1800471 with CKD, possibly because they calculated the pooled ORs using a relatively small sample size and applied distinct contrast models.…”

Section: Discussionmentioning

confidence: 99%

Association of TGF-β1, IL-4, and IL-10 Polymorphisms With Chronic Kidney Disease Susceptibility: A Meta-Analysis

Mai

Jiang

et al. 2020

Front. Genet.

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Background: Anti-inflammatory cytokine polymorphisms in the transforming growth factor-b1 (TGF-b1), interleukin-4 (IL-4), and IL-10 genes have been implicated as risk factors for chronic kidney disease (CKD), but the results from published studies are inconsistent. Our meta-analysis reviews and summarizes the cumulative evidence for these associations. Methods: A systematic literature search of five databases was performed up to October 2019. Two authors independently extracted data and evaluated the quality of included studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were generated from random-effects or fixed-effects models using Stata 12.0. Results: Nineteen studies from 10 countries satisfied our inclusion criteria and were included in the meta-analysis. Overall, the pooled analysis showed that TGF-b1 rs1800469 was associated with decreased susceptibility to CKD (CC + TC vs. TT, OR = 0.33, 95% CI: 0.15-0.76, P = 0.009; CC vs. TT, OR = 0.33, 95% CI: 0.15-0.73, P = 0.006), whereas TGF-b1 rs1800471 was associated with increased CKD susceptibility (CC vs. CG + GG, OR = 1.68, 95% CI: 1.02-2.77, P = 0.041). In stratified analyses based on ethnicity, TGF-b1 rs1800469 was associated with CKD susceptibility in Asians and Caucasians, and there was an association of TGF-b1 rs1800470 and IL-4 rs8179190 with CKD in Asians. Stratified analyses also associated TGF-b1 rs1800471 with CKD susceptibility in Caucasians. Neither overall meta-analyses nor stratified analyses identified an association of the IL-10 rs1800869 and rs1800871 polymorphisms with susceptibility to CKD. Conclusions: Available data suggest that common polymorphisms in the TGF-b1 and IL-4 genes including rs1800469, rs1800470, rs1800471, and rs8179190 may be important genetic contributors to CKD susceptibility.

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“…However, previous studies have reported conflicting results relating to the association between TGF-β1 SNPs and CKD. An increased risk was noted with rs1800471 in a European population, 19 whereas a recent meta-analysis 33 has shown increased CKD risk (in the non-HIV-infected population) among Asians and a CKD-protective effect of another TGF-β1 variant. Therefore, the effect of TGF-β1 polymorphisms on CKD remains inconclusive.…”

Section: Discussionmentioning

confidence: 99%

Association of Genetic Polymorphisms of TGF-β1, HMOX1, and APOL1 With CKD in Nigerian Patients With and Without HIV

Ekrikpo

Mnika

Effa

et al. 2020

American Journal of Kidney Diseases

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Association of transforming growth factor-β1 polymorphisms with the risk of chronic kidney diseases

Cited by 9 publications

References 30 publications

The role of TGF-β1 869 T > C and PPAR γ2 34 C > G polymorphisms, fat mass, and anthropometric characteristics in predicting childhood obesity at birth

The role of TGF-β1 869 T > C and PPAR γ2 34 C > G polymorphisms, fat mass, and anthropometric characteristics in predicting childhood obesity at birth

Association of TGF-β1, IL-4, and IL-10 Polymorphisms With Chronic Kidney Disease Susceptibility: A Meta-Analysis

Association of Genetic Polymorphisms of TGF-β1, HMOX1, and APOL1 With CKD in Nigerian Patients With and Without HIV

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