Association of Total White Cell Count with Mortality and Major Adverse Events in Patients with Peripheral Arterial Disease: A Systematic Review

Martin, David T.; Wallace, Dennis; Crowe, Maggie; Rush, Catherine M.; Tosenovsky, Patrick; Golledge, Jonathan

doi:10.1016/j.ejvs.2013.12.020

Cited by 9 publications

(2 citation statements)

References 74 publications

(115 reference statements)

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“…The influence of inflammatory processes and, thus, of white blood cells on atherosclerotic disease is widely recognized [33]. In 2014, Martin et al published a review postulating a positive association of the WBC count with mortality rates and with the occurrence of major adverse events in PAD patients [34]. Regarding platelets in the field of atherosclerosis and atherothrombosis, their role covers not only participation in clot formation, but also involvement in inflammatory processes.…”

Section: Discussionmentioning

confidence: 99%

The White Blood Cell Count to Mean Platelet Volume Ratio for the Prediction of Chronic Limb-Threatening Ischemia in Lower Extremity Artery Disease

Guetl

Raggam

Muster

et al. 2019

JCM

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: Background: The white blood cell count to mean platelet volume ratio (WMR) is increasingly gaining importance as a promising prognostic marker in atherosclerotic disease, but data on lower extremity artery disease (LEAD) are not yet available. The principle aim of this study was to assess the association of the WMR with the occurrence of CLTI (chronic limb-threatening ischemia) as the most advanced stage of disease. Methods: This study was performed as a retrospective analysis on 2121 patients with a diagnosis of LEAD. Patients were admitted to the hospital for the reason of LEAD and received conservative or endovascular treatment. Blood sampling, in order to obtain the required values for this analysis, was implemented at admission. Statistical analysis was conducted by univariate regression in a first step and, in case of significance, by multivariate regression additionally. Results: Multivariate regression revealed an increased WMR (p < 0.001, OR (95%CI) 2.258 (1.460–3.492)), but also advanced age (p < 0.001, OR (95%CI) 1.050 (1.040–1.061)), increased CRP (p < 0.001, OR (95%CI) 1.010 (1.007–1.014)), and diabetes (p < 0.001, OR (95%CI) 2.386 (1.933–2.946)) as independent predictors for CLTI. Conclusions: The WMR presents an easily obtainable and cost-effective parameter to identify LEAD patients at high risk for CLTI.

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Section: Discussionmentioning

confidence: 99%

The White Blood Cell Count to Mean Platelet Volume Ratio for the Prediction of Chronic Limb-Threatening Ischemia in Lower Extremity Artery Disease

Guetl

Raggam

Muster

et al. 2019

JCM

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“…Chronic inflammation is a risk factor of hypertension [1,2,[4][5][6][7][8][9]. However current evidence of this risk factor is mainly based on the association between high-sensitivity C-reactive protein and hypertension, and is mainly derived from Western populations [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

White blood cell count and incidence of hypertension in the general Japanese population: ISSA-CKD study

et al. 2021

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Objectives This study aimed to clarify the relationship between the white blood cell (WBC) count and hypertension in the general Japanese population. Methods We conducted a population-based retrospective cohort study using annual health check-up data of residents of Iki City, Nagasaki Prefecture, Japan. A total of 2935 participants without hypertension at baseline were included in the present analysis. WBC counts were classified as tertile 1 (<4700/μL), tertile 2 (4700–5999/μL), and tertile 3 (≥6000/μL). The outcome was incident hypertension (blood pressure ≥140 mmHg). Multivariable-adjusted hazard ratios and 95% confidence intervals (95% CIs) were estimated using the Cox proportional hazards model. Result During an average follow-up of 4.5 years, 908 participants developed hypertension. The incidence (per 100 person-years) of hypertension increased with an elevation in the WBC count (6.3 in tertile 1, 7.0 in tertile 2, and 7.4 in tertile 3). This association was significant, even after adjustment for other risk factors, including age, sex, current smoking habits, current alcohol intake, exercise habits, obesity, elevated blood pressure, diabetes mellitus, and dyslipidemia. The hazard ratios were 1.07 for tertile 2 (95% CI 0.90–1.26) and 1.27 for tertile 3 (95% CI 1.06–1.51) compared with the reference group of tertile 1 (p = 0.009). Conclusion The WBC count was associated with future development of hypertension in the general Japanese population.

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2018

Cardiovascular Disease

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Association of Total White Cell Count with Mortality and Major Adverse Events in Patients with Peripheral Arterial Disease: A Systematic Review

Abstract: Current evidence suggests a positive association of TWCC with mortality and MAEs in patients with PAD. Further well-designed prospective studies are required with high-quality analysis and more complete reporting of outcomes.

Cited by 9 publications

References 74 publications

The White Blood Cell Count to Mean Platelet Volume Ratio for the Prediction of Chronic Limb-Threatening Ischemia in Lower Extremity Artery Disease

The White Blood Cell Count to Mean Platelet Volume Ratio for the Prediction of Chronic Limb-Threatening Ischemia in Lower Extremity Artery Disease

White blood cell count and incidence of hypertension in the general Japanese population: ISSA-CKD study

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