Association of total cancer and lung cancer with environmental exposure to cadmium: the meta-analytical evidence

Nawrot, Tim S.; Martens, Dries S.; Hara, Azusa; Plusquin, Michelle; Vangronsveld, Jaco; Roels, Harry; Staessen, Jan A.

doi:10.1007/s10552-015-0621-5

Cited by 75 publications

(24 citation statements)

References 34 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current study also found that higher urinary Cd was associated with CVD risk factors such as hypertension, aspirin use, and history of CHD or stroke, consistently with a previous report linking urinary Cd to CVD [44]. We also found that greater urinary Cd was associated with cancer history, which is consistent with previous studies showing that higher urinary Cd level was associated with total cancer, lung cancer [45] and breast cancer risk in Japanese women [46].…”

Section: Discussionsupporting

confidence: 92%

Association between Urinary Cadmium-to-Zinc Intake Ratio and Adult Mortality in a Follow-Up Study of NHANES 1988–1994 and 1999–2004

et al. 2019

View full text Add to dashboard Cite

Cadmium (Cd) is a toxic heavy metal associated with increased mortality, but the effect of zinc (Zn) intake on the association between Cd and mortality is unknown. The objective of this study was to examine the association of urinary Cd to Zn intake ratio (Cd/Zn ratio) and mortality risk. In total, 15642 US adults in NHANES 1988–1994 and 1999–2004 were followed until 2011 (15-year mean follow-up). Of the 5367 total deaths, 1194 were attributed to cancer and 1677 were attributed to CVD. After adjustment for potential confounders, positive associations were observed between urinary Cd and all-cause mortality (HR for highest vs. lowest quartile: 1.38; 95% CI: 1.14–1.68) and cancer mortality (HR: 1.54; CI: 1.05–2.27). Urinary Cd was positively associated with cancer mortality among the lowest Zn consumers, and the association diminished among the highest Zn consumers. Positive relationships were observed between the Cd/Zn ratio and all-cause mortality (HR: 1.54; CI: 1.23–1.93), cancer mortality (HR: 1.65; CI: 1.11–2.47) and CVD mortality (HR: 1.49; CI: 1.18–1.88). In conclusion, these findings indicate that Zn intake may modify the association between Cd and mortality. Furthermore, the Cd/Zn ratio, which was positively associated with mortality from all causes, cancer, and CVD, may be an important predictor of mortality.

show abstract

Section: Discussionsupporting

confidence: 92%

Association between Urinary Cadmium-to-Zinc Intake Ratio and Adult Mortality in a Follow-Up Study of NHANES 1988–1994 and 1999–2004

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Nickel is an established carcinogen for lung and nasal cancer, and excess risk of nasal cancer has been previously documented among welders [39] , [40] . Occupational cadmium exposure has been causally linked with lung cancer [41] , and some studies have suggested associated risks of kidney and bladder cancer [42] . A 2012 IARC review of the carcinogenicity of UV radiation found strong evidence attributing ocular melanoma to welding exposure [43] .…”

Section: Introductionmentioning

confidence: 99%

Cancer Risks among Welders and Occasional Welders in a National Population-Based Cohort Study: Canadian Census Health and Environmental Cohort

MacLeod

Harris

Tjepkema

et al. 2017

Safety and Health at Work

View full text Add to dashboard Cite

BackgroundWelders are exposed to many known and suspected carcinogens. An excess lung cancer risk among welders is well established, but whether this is attributable to welding fumes is unclear. Excess risks of other cancers have been suggested, but not established. We investigated welding cancer risks in the population-based Canadian Census Health and Environmental Cohort.MethodsAmong 1.1 million male workers, 12,845 welders were identified using Standard Occupational Classification codes and followed through retrospective linkage of 1991 Canadian Long Form Census and Canadian Cancer Registry (1992–2010) records. Hazard ratios (HRs) were calculated using Cox proportional hazards models based on estimated risks of lung cancer, mesothelioma, and nasal, brain, stomach, kidney, and bladder cancers, and ocular melanoma. Lung cancer histological subtypes and risks by industry group and for occasional welders were examined. Some analyses restricted comparisons to blue-collar workers to minimize effects of potential confounders.ResultsAmong welders, elevated risks were observed for lung cancer [HR: 1.16, 95% confidence interval (CI): 1.03–1.31], mesothelioma (HR: 1.78, 95% CI: 1.01–3.18), bladder cancer (HR: 1.40, 95% CI: 1.15–1.70), and kidney cancer (HR: 1.30, 95% CI: 1.01–1.67). When restricted to blue-collar workers, lung cancer and mesothelioma risks were attenuated, while bladder and kidney cancer risks increased.ConclusionExcess risks of lung cancer and mesothelioma may be partly attributable to factors including smoking and asbestos. Welding-specific exposures may increase bladder and kidney cancer risks, and particular sources of exposure should be investigated. Studies that are able to disentangle welding effects from smoking and asbestos exposure are needed.

show abstract

“…Multiple previous studies had found inequalities regarding smoking, occupation-related exposure to carcinogens and lung cancer. [4][5][6][7][8] The main explanation for inequality in lung cancer incidence is that social inequalities tobacco consumption and occupation-related exposures may play a role. 8 In Germany, the rates of smokers were decreasing from 1999 to 2013, but in men holding higher socioeconomic positions, this development took place at a faster pace than in lower positions.…”

Section: Discussionmentioning

confidence: 99%

Are there social gradients in the occurrence of lung cancer and in the survival of lung cancer patients? Findings from an observational study using German claims data of Lower Saxony

et al. 2020

View full text Add to dashboard Cite

ObjectivesOnly a few studies on health inequalities in terms of lung cancer are available. We examined whether social inequalities are present for the occurrence of lung cancer. Confining the analyses to patients, it was also examined whether survival over the observation period and over a standardised period of 18 months differed by occupational position and income.MethodsOur findings are based on claims data from a German statutory health insurance covering 2005–2016. The database comprised N=3 163 211 women (50.7%) and men (49.3%) aged 18 years and older. Diagnoses (International Statistical Classification of Diseases and Related Health Problems 10th Revision: C34.0 to C34.9) were hospital-based, and income and occupational position were used as indicators of socioeconomic position. Analyses on social gradients were performed for employed and retired insured, but only for employed insured information on occupation and on income were available, for retired women and men only income was available. Analyses were performed by means of proportional hazard regression.ResultsIn employed women, social gradients for the occurrence emerged for occupational position, but not for income. In men, social differences were found for both indicators. For retired insured, income gradients were found in men. Looking at overall survival, neither in women nor in men social gradients emerged.ConclusionsThe reported social inequalities in the occurrence of lung cancer are pointing towards social differences in smoking behaviour, exposition to hazardous occupation-related substances and differences in preventive strategies. The absence of social inequalities in survival after lung cancer suggests equality in medical treatment of the disease.

show abstract

Association of total cancer and lung cancer with environmental exposure to cadmium: the meta-analytical evidence

Abstract: The epidemiological evidence of the last decade consistently identifies low-level environmental exposure to cadmium as a risk factor for total cancer and lung cancer.

Cited by 75 publications

References 34 publications

Association between Urinary Cadmium-to-Zinc Intake Ratio and Adult Mortality in a Follow-Up Study of NHANES 1988–1994 and 1999–2004

Association between Urinary Cadmium-to-Zinc Intake Ratio and Adult Mortality in a Follow-Up Study of NHANES 1988–1994 and 1999–2004

Cancer Risks among Welders and Occasional Welders in a National Population-Based Cohort Study: Canadian Census Health and Environmental Cohort

Are there social gradients in the occurrence of lung cancer and in the survival of lung cancer patients? Findings from an observational study using German claims data of Lower Saxony

Contact Info

Product

Resources

About