Association of toll-like receptors in malaria susceptibility and immunopathogenesis: A meta-analysis

Ramírez, Aina D.R.; Jesus, Myrela Conceição Santos de; Rossit, Júlia; Reis, Nathália Faria; Santos-Filho, Marcelo Cerilo dos; Sudré, Adriana Pittella; Oliveira-Ferreira, Joseli; Baptista, Andréa Regina de Souza; Storti-Melo, Luciane Moreno; Machado, Ricardo Luiz Dantas

doi:10.1016/j.heliyon.2022.e09318

Cited by 6 publications

(1 citation statement)

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“…This finding suggests the role of DNA methylation in the recognition of pathogens by Kuppfer cells in the liver [ 43 ]. The tissue damage caused by inflammation in malaria and the relation between TLR6 and malaria severity in P. falciparum and P. vivax infections [ 141 ] enforces the need for further investigation of Tlr6 and other genes of the Tlr family.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Apicomplexa Looking into Epigenetic Pathways and the Opportunity for Novel Therapies

Brandão

Molento

2023

Pathogens

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Interest in host epigenetic changes during apicomplexan infections increased in the last decade, mainly due to the emergence of new therapies directed to these alterations. This review aims to carry out a bibliometric analysis of the publications related to host epigenetic changes during apicomplexan infections and to summarize the main studied pathways in this context, pointing out those that represent putative drug targets. We used four databases for the article search. After screening, 116 studies were included. The bibliometric analysis revealed that the USA and China had the highest number of relevant publications. The evaluation of the selected studies revealed that Toxoplasma gondii was considered in most of the studies, non-coding RNA was the most frequently reported epigenetic event, and host defense was the most explored pathway. These findings were reinforced by an analysis of the co-occurrence of keywords. Even though we present putative targets for repurposing epidrugs and ncRNA-based drugs in apicomplexan infections, we understand that more detailed knowledge of the hosts’ epigenetic pathways is still needed before establishing a definitive drug target.

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Section: Resultsmentioning

confidence: 99%