Association of TNF-α but not IL-1β levels with the presence of Helicobacter pylori infection increased the risk of peptic ulcer development

Tourani, Mehdi; Habibzadeh, Maryam; Karkhah, Ahmad; Shokri‐Shirvani, Javad; Barari, Ladan; Nouri, Hamid Reza

doi:10.1016/j.cyto.2018.01.003

Cited by 29 publications

(29 citation statements)

References 22 publications

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“…Each experiment was repeated at least three times. IL-1β Level was measured by ELISA method, according to the manual of IL-1β ELISA development kit (HRP) (Mabtech AB, Sweden) as previously described (Tourani et al, 2018).…”

Section: Measurement Of Il-1β Level By Elisamentioning

confidence: 99%

Decrease of intracellular ROS by arbutin is associated with apoptosis induction and downregulation of IL‐1β and TNF‐α in LNCaP; prostate cancer

et al. 2020

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Increased reactive oxygen species (ROS) along with inflammation are involved in the prostate cancer (PCa). Therefore, this study was conducted to investigate the molecular mechanisms that were affected by arbutin as an antioxidant on prostate cancer cell line; LNCap. The intracellular ROS measurement confirmed that arbutin significantly (p < .05) decreased the ROS levels in a dose‐dependent manner. Detection of cell death profile established that 1,000 μM of arbutin could remarkably induced apoptosis (p < .05), while tert‐butyl hydroperoxide (tBHP) as ROS inducer prompted necrosis. In addition, 1,000 µM of arbutin successfully decreased expressions of IL‐1β and TNF‐α genes (p < .05). Furthermore, evaluation of the IL‐1β protein level showed that arbutin could significantly decrease this cytokine (p < .05). In summary, reduction of ROS along with increasing apoptosis and decreasing expression of pro‐inflammatory genes following arbutin treatment can open new visions in the treatment of prostate cancer using complementary medicine. Practical applications Nowadays, arbutin as a glycosylated hydroquinone is available commercially in both natural and synthetic forms. Arbutin is of interest because of its skin‐lightening effect, and used in cosmetic products for cutaneous hyperpigmentation. Arbutin inhibited tyrosinase in melanocytes competitively. Moreover, arbutin was able to attenuate oxidative stress and, its anti‐inflammatory activities has been established. In addition, arbutin has represented useful activities for suppression of malignant melanoma development. In addition, arbutin exhibits several pharmacological effects, including antimicrobial, antihyperlipidemic, antihyperglycemic, and alpha amylase inhibitory effects. In this study, we showed its effect on prostate cancer in vitro. Therefore, it opens new insights in the complementary medicine that can maintain or improve human health.

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Section: Measurement Of Il-1β Level By Elisamentioning

confidence: 99%

Decrease of intracellular ROS by arbutin is associated with apoptosis induction and downregulation of IL‐1β and TNF‐α in LNCaP; prostate cancer

et al. 2020

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“…About 10% of the population develop peptic ulcers, atrophic gastritis, gastric cancer and MALT lymphoma. [24][25][26][27] More and more evidence shows that Hp strain, the host, the presence of cyclobacteria and other factors jointly determine the occurrence and development of the disease. [28] As an important part of the micro-ecological environment in the stomach, gastric ora maintain the balance of the gastric environment through a variety of regulatory pathways.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Characteristics and Differential Diagnosis of Signet-ring Cell Carcinoma of Gastric Pit Epithelium

Zhang

Deng

Huang

et al. 2020

Preprint

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Background:To investigate the clinicopathological characteristics, immunophenotype and differential diagnosis of signet-ring cell carcinoma of gastric pit epithelium. Methods Seven cases of signet-ring cell carcinoma of gastric pit epithelium were studied by histomorphology observation, special staining, immunohistochemical staining and follow-up. Results At the initial stage, the glands proliferated and expanded, and the cells morphologically transformed into signet ring-like atypical cells and then formed clonal hyperplastic signet-ring cell carcinoma, which expanded laterally along the gastric pit, with a length of 3–6 mm. Erosion or mucosal ulcers can be formed on the surface, and the atrophy of fundus or pylorus glands leads to local depression of gastric mucosa. PAS was positive by special staining. Immunophenotype testing included MUC5AC, CKpan, CK20, CEA, villin and CDX2 with positive expression. In cytology, five cell morphologies could be seen: classic, immature, high proliferation, non-nucleus vacuole and degeneration. Three out of seven cases were accompanied by Helicobacter pylori (Hp) infection, accounting for 42.9% of the cases. Conclusion The signet-ring cell carcinoma of gastric pit epithelium originates from the proliferative region of the gastric fundus and the neck of gastric gland, which grows laterally along the gastric pit and is easy to be missed and misdiagnosed. Attention should be paid to the differential diagnosis, and the recognition level of signet-ring cell carcinoma of gastric pit epithelium should be improved.

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“…In particular, HBV carriers with high AST or TG levels are prone to induce erosive esophagitis, and this phenomenon is more common in women in terms of population probability. Moreover, further studies (Asanuma et al, 2016;Tourani et al, 2018) showed that not only can Estrogen block the development of GERD through antiinflammatory and regulation of fat metabolism but also control the severity of chronic gastritis associated with high levels of TNF-a. In addition, there might be a complex interaction between hiv-1 protein and TNF/TNFR signaling to regulate peptic ulcer development (Pasquereau et al, 2017).…”

Section: Main Pharmacological Mechanismsmentioning

confidence: 99%

Efficacy of Chinese Herbal Formula Sini Zuojin Decoction in Treating Gastroesophageal Reflux Disease: Clinical Evidence and Potential Mechanisms

Huang

et al. 2020

Front. Pharmacol.

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Background: Based on 122 cases reported in China, data mining indicated that Sini Powder (SNP) and the Zuojin Pill (ZJP) are both widely used as the basic recipe for treating Gastroesophageal Reflux Disease (GERD). Objectives: To evaluate the intervention effects of Sini Zuojin Decoction (SNZJD) in patients with GERD. Methods: A comprehensive collection of randomized controlled trials (RCTs) using SNZJD in patients with GERD that were published in domestic and foreign journals was made by computer retrieval. RevMan 5.3 software was used for meta-analysis and bias risk assessment, Stata 14.0 software was used for sensitivity analysis, GRADE profiler 3.6 was used to evaluate the level of evidence, and trial sequential analysis (TSA), employed to control for random errors, was performed to assess the main outcomes. Network pharmacology analysis was applied to preliminarily study the mechanisms of action of SNZJD on GERD. Results: Thirteen articles were eventually included, covering a total of 966 patients. Metaanalysis indicated that: ① the SNZJD plus traditional stomach medicines (SPTSM) group was more effective than the traditional stomach medicines (TSM) group (RR = 1.16, 95% CI [1.04, 1.29], P = 0.009); ② the experimental group with SNZJD was significantly better than TSM controls in improving heartburn, substernal chest pain, acid regurgitation, and food regurgitation symptoms (P < 0.0001); ③ SPTSM could significantly decrease total symptom scores with substantial effectiveness (P < 0.00001). The recurrence rate and adverse effects of SNZJD treatment were significantly reduced (P < 0.05). TSA showed that the effective rate of meta-analysis might be reliable, but the recurrence and safety results were still uncertain. According to the evaluation by the GRADE method, the quality

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Association of TNF-α but not IL-1β levels with the presence of Helicobacter pylori infection increased the risk of peptic ulcer development

Cited by 29 publications

References 22 publications

Decrease of intracellular ROS by arbutin is associated with apoptosis induction and downregulation of IL‐1β and TNF‐α in LNCaP; prostate cancer

Decrease of intracellular ROS by arbutin is associated with apoptosis induction and downregulation of IL‐1β and TNF‐α in LNCaP; prostate cancer

Clinicopathological Characteristics and Differential Diagnosis of Signet-ring Cell Carcinoma of Gastric Pit Epithelium

Efficacy of Chinese Herbal Formula Sini Zuojin Decoction in Treating Gastroesophageal Reflux Disease: Clinical Evidence and Potential Mechanisms

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