Association of TNF-α-308 G&gt;A (rs1800629) polymorphism with susceptibility of metabolic syndrome

Ghareeb, Dalia; Abdelazem, Abdallah S.; Hussein, Ekhlas; Al-Karamany, Amira S.

doi:10.1007/s40200-021-00732-3

Cited by 17 publications

(16 citation statements)

References 28 publications

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“…Association between the TNFA rs1800629 SNP and blood lipid levels produced conflicting results so far, mainly due to a wide variability of ethnicity, baseline CV risk, and interventions [ 23 , 24 , 25 ]. Here, we showed that the minor A allele is associated with higher TC and triglycerides.…”

Section: Discussionmentioning

confidence: 99%

The Association between Single Nucleotide Polymorphisms, including miR-499a Genetic Variants, and Dyslipidemia in Subjects Treated with Pharmacological or Phytochemical Lipid-Lowering Agents

Giuliani

Montesanto

Matacchione

et al. 2022

IJMS

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Disorders of lipoprotein metabolism are among the major risk factors for cardiovascular disease (CVD) development. Single nucleotide polymorphisms (SNPs) have been associated with the individual variability in blood lipid profile and response to lipid-lowering treatments. Here, we genotyped 34 selected SNPs located in coding genes related to lipid metabolism, inflammation, coagulation, and a polymorphism in the MIR499 gene—a microRNA previously linked to CVD—to evaluate the association with lipid trait in subjects with moderate dyslipidemia not on lipid-lowering treatment (Treatment-naïve (TN) cohort, n = 125) and in patients treated with statins (STAT cohort, n = 302). We also explored the association between SNPs and the effect of a novel phytochemical lipid-lowering treatment in the TN cohort. We found that 6 SNPs (in the MIR499, TNFA, CETP, SOD2, and VEGFA genes) were associated with lipid traits in the TN cohort, while no association was found with the response to twelve-week phytochemical treatment. In the STAT cohort, nine SNPs (in the MIR499, CETP, CYP2C9, IL6, ABCC2, PON1, IL10, and VEGFA genes) were associated with lipid traits, three of which were in common with the TN cohort. Interestingly, in both cohorts, the presence of the rs3746444 MIR499 SNP was associated with a more favorable blood lipid profile. Our findings could add information to better understand the individual genetic variability in maintaining a low atherogenic lipid profile and the response to different lipid-lowering therapies.

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Section: Discussionmentioning

confidence: 99%

The Association between Single Nucleotide Polymorphisms, including miR-499a Genetic Variants, and Dyslipidemia in Subjects Treated with Pharmacological or Phytochemical Lipid-Lowering Agents

Giuliani

Montesanto

Matacchione

et al. 2022

IJMS

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“…It is important to emphasize here that TNF-⍺ is a well-known pleiotropic gene, in which the same gene or genetic variant has an effect in different traits. The pleiotropic effect of genetic polymorphisms may explain part of the associations observed in epidemiological studies between AP and different systemic alterations, such as metabolic syndrome (Ghareeb et al, 2021; # was used to represent the significance of CVC. González-Navarro et al, 2020), ischaemic heart disease (Kamdee et al, 2021) and diabetes (Shi et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…It is important to emphasize here that TNF‐ ⍺ is a well‐known pleiotropic gene, in which the same gene or genetic variant has an effect in different traits. The pleiotropic effect of genetic polymorphisms may explain part of the associations observed in epidemiological studies between AP and different systemic alterations, such as metabolic syndrome (Ghareeb et al, 2021; González‐Navarro et al, 2020), ischaemic heart disease (Kamdee et al, 2021) and diabetes (Shi et al, 2021). The literature highlights an association between the A allele in the rs1800629 variation in TNF‐ ⍺ as a protective factor to diseases related to bone metabolism, such as acute AP, osteoporosis, and bone fracture risk (Amaya et al, 2013; de Sá et al, 2007; Jin et al, 2018; Kotrych et al, 2016; Moffett et al, 2005), data that corroborate with the results observed in the present study.…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphism in the tumour necrosis factor alpha gene (G‐308A) is associated with persistent apical periodontitis in Brazilians

et al. 2022

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Aim: To investigate if there was an association between genetic polymorphisms in tumour necrosis factor (TNF)-⍺ and its receptors TNFRSF1A and TNFRSF1B with persistent apical periodontitis (PAP) in Brazilian subjects. Methodology:Patients who had pulpal necrosis and apical periodontitis at the time of treatment, with at least 1-year of follow-up after non-surgical root canal treatment were recalled. Three hundred and seventy eight subjects were included, 150 subjects with signs/symptoms of PAP and 228 subjects with root canal-treated teeth exhibiting healthy perirradicular tissues (healed). Genomic DNA was extracted from saliva and used for TNF-⍺ (rs1800629), TNFRSF1A (rs1800693) and TNFRSF1B (rs1061622) genotyping by real-time PCR. Genotypes and alleles frequencies were evaluated by c2 or Fisher's exact tests and odds ratios were implemented (α = 5%). Results:The genetic polymorphism in TNF-α (rs1800629) was associated as a protective factor for the development of PAP (p < .05), once subjects who presented at least one allele A (AA+AG X GG), had a higher chance to lesion repair (p < .05). The polymorphisms rs1800693 and rs1061622 in TNF receptors (TNFRSF1A and TNFRSF1B, respectively) were not associated with the development of PAP (p > .05). Conclusions:The observed results demonstrate that polymorphism in TNF-α but not in its receptors is associated with PAP.

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“…It is noteworthy that these studies are still controversial regarding methodological and sampling variables, from the point of view of disease, treatment, and ethnic and individual factors (14,130). The pleiotropic effect of genetic polymorphisms may explain part of the associations observed in epidemiological studies between AP and different systemic alterations, such as metabolic syndrome (131,132), ischemic heart disease (133) and diabetes (134). Additionally, a recent review emphasized the need for further studies within new cohorts of different populations and ethnicities to either confirm or refute the role of genetic polymorphisms in AP (135).…”

Section: Influence Of Genetic Polymorphisms On Apical Periodontitis R...mentioning

confidence: 99%

Genetic, Cellular and Molecular Aspects involved in Apical Periodontitis

et al. 2022

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The development, establishment and repair of apical periodontitis (AP) is dependent of several factors, which include host susceptibility, microbial infection, immune response, quality of root canal treatment and organism's ability to repair. The understanding of genetic contributions to the risk of developing AP and presenting persistent AP has been extensively explored in modern Endodontics. Thus, this article aims to provide a review of the literature regarding the biochemical mediators involved in immune response signaling, osteoclastogenesis and bone neoformation, as the genetic components involved in the development and repair of AP. A narrative review of the literature was performed through a PUBMED/MEDLINE search and a hand search of the major AP textbooks. The knowledge regarding the cells, receptors and molecules involved in the host's immune-inflammatory response during the progression of AP added to the knowledge of bone biology allows the identification of factors inherent to the host that can interfere both in the progression and in the repair of these lesions. The main outcomes of studies evaluated in the review that investigated the correlation between genetic polymorphisms and AP in the last five years, demonstrate that genetic factors of the individual are involved in the success of root canal treatment. The discussion of this review gives subsides that may help to glimpse the development of new therapies based on the identification of therapeutic targets and the development of materials and techniques aimed at acting at the molecular level for clinical, radiographic and histological success of root canal treatment.

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Association of TNF-α-308 G>A (rs1800629) polymorphism with susceptibility of metabolic syndrome

Cited by 17 publications

References 28 publications

The Association between Single Nucleotide Polymorphisms, including miR-499a Genetic Variants, and Dyslipidemia in Subjects Treated with Pharmacological or Phytochemical Lipid-Lowering Agents

The Association between Single Nucleotide Polymorphisms, including miR-499a Genetic Variants, and Dyslipidemia in Subjects Treated with Pharmacological or Phytochemical Lipid-Lowering Agents

Genetic polymorphism in the tumour necrosis factor alpha gene (G‐308A) is associated with persistent apical periodontitis in Brazilians

Genetic, Cellular and Molecular Aspects involved in Apical Periodontitis

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