Association of timed up and go test outcomes with future incidence of cardiovascular disease and mortality in adults aged 66 years: Korean national representative longitudinal study over 5.7 years

Abstract

Background: The timed up and go test (TUG) is one of the most widely used tests of mobility. We aimed to examine whether the TUG is associated with cardiovascular (CV) events, CV mortality, and all-cause mortality. Methods: Subjects in the senior cohort database of the Korean National Health Insurance Service (2002-2013) who completed the TUG as part of the National Screening Program for Transitional Ages (NSPTA) during 2007-2008 were identified. An abnormal TUG result was defined as a time ≥ 10 s. Cox proportional hazard models were used to assess the associations between TUG results and CV events, CV mortality, and all-cause mortality.Results: The mean follow-up period was 5.7 years. Incidence rates of CV events in the normal and abnormal TUG groups were 7.93 and 8.98 per 1000 person-years, while CV mortality rates were 0.96 and 1.51 per 1000 personyears, respectively. In a fully adjusted model, we found that abnormal TUG results were not associated with the incidences of CV events and CV mortality. However, abnormal TUG results (≥10 s) resulted in a 2.9-fold increase in CV mortality in women (adjusted hazard ratio 2.90, 95% confidence interval 1.15-7.30). Further, participants lacking certain CV risk factors, such as current cigarette smoking, obesity, or diabetes, had a higher CV mortality rate when TUG results were abnormal. Conclusions: Abnormal TUG results in subjects aged 66 years were associated with future CV mortality in women and in subjects without obesity, diabetes, or cigarette smoking. In patient with mobility impairment, physicians should consider CV disease risk, especially in women.

The Relationship between Health Perception and Health Predictors among the Elderly across European Countries

“…This quite easy test has been considered a useful tool for evaluating the risk of falling among the elderly [5]. It is a quick and straightforward clinical test for assessing lower extremity performance related to balance, mobility, and fall risk in the elderly population and people with pathologies [35,36,50].…”

“…Lower extremity performance is associated with strength, but also with balance, mobility, and fall risk among the elderly and people with pathologies (i.e., Parkinson's disease, post-stroke patients, cardiovascular incidents) and can be determined through time in an Up and Go test (TUG) [35,36]. In some studies, TUG was shown to be an efficient test in the prediction of falls among the elderly, as a direct relationship was observed between the occurrence of falls in the elderly and their classifications according to the test [5,37].…”

Identifying Key Predictors of Cognitive Dysfunction in Older People Using Supervised Machine Learning Techniques: Observational Study (Preprint)

“…Moreover, the TUG test can be considered, in a sense, a global measure of body function. Poor performance has been associated with increased cardiovascular disease and mortality as well as all-cause mortality in older adults [53][54][55] and in patients with chronic kidney disease [56]. Additional predictors beyond the TUG score selected in the decision trees as informative are also linked with poor cognitive performance, including a measure of kidney function, GFR.…”

Experimental Study for Determining the Parameters Required for Detecting ECG and EEG Related Diseases during the Timed-Up and Go Test

“…One of the most common tests for the assessment of the performance of the lower limbs is the Timed-Up and Go test, where the analysis of the data acquired from different sources allows the recognition of several healthcare problems, including balance, mobility, fall risk, Parkinson's disease, amyotrophic lateral sclerosis, and other orthopedic, cardiovascular and brain pathologies [30][31][32][33][34][35].…”