Association of time in range with lower extremity atherosclerotic disease in type 2 diabetes mellitus: a prospective cohort study

Wang, Yaxin; Lu, Jingyi; Shen, Yun; Ni, Jiaying; Zhang, Lei; Lü, Wei; Zhu, Wei; Bao, Yuqian; Zhou, Jian

doi:10.1007/s12020-022-03038-3

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…In addition, we compared the predictive value for incident DR between GRI and other glycaemic metrics including TIR, TAR and HbA1c. As evidence has accumulated supporting the associations of TIR with the risk of numerous diabetes-related outcomes, [8][9][10][11][12][13][26][27][28] TIR has been advocated as a key CGM metric. With regard to DR, from our previous analysis of cross-sectional data from 3262 patients with type 2 diabetes, we observed that TIR obtained from 3-day CGM data is related to varying degrees of DR. 14 Furthermore, in a post hoc analysis of the seven-point self-monitored blood glucose data from the Diabetes Control and Complications Trial, TIR was also found to be strongly associated with the risk of retinopathy progression in type 1 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association between glycaemia risk index (GRI) and diabetic retinopathy in type 2 diabetes: A cohort study

Wang

et al. 2023

Diabetes Obesity Metabolism

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Aim: To investigate the association between a new composite metric, glycaemia risk index (GRI), and incident diabetic retinopathy (DR).Methods: A total of 1204 adults with type 2 diabetes without DR at baseline were included between 2005 and 2019 from a single centre in Shanghai, China. GRI was obtained from continuous glucose monitoring data at baseline. Cox proportion hazard regression analysis was used to assess the association between GRI and the risk of incident DR.Results: During a median follow-up of 8.4 years, 301 patients developed DR. The multivariable-adjusted hazard ratios (HRs) for incident DR across ascending GRI quartiles (≤14 [reference], 15 $ 28, 29 $ 47 and > 47) were 1.00, 1.05 (95% CI 0.74-1.48), 1.33 (95% confidence interval [CI] 0.96-1.84) and 1.53 (95% CI 1.11-2.11), respectively. For each 1-SD increase in GRI, the risk of DR was increased by 20% (HR 1.20, 95% CI 1.07-1.33) after adjustment for confounders. Conclusions:In patients with type 2 diabetes, higher GRI is associated with an increased risk of incident DR. GRI has the potential to be a valuable clinical measure, which needs to be further explored in future studies.

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