Association of Thyroid Hormones Level with Coronary Lesion Complexity in Patients with Acute Coronary Syndrome

Abstract

Aim: Our aim was to study the correlation between the thyroid hormones level and the coronary lesion complexity in patients with acute coronary syndrome (ACS). Patients and Methods: This is a prospective which included 100 patients with ACS who were admitted for percutaneous coronary intervention (PCI). The patients were divided according to thyroid functions into 3 groups: Euthyroid patients (90 patients), hyperthyroid patients (2 patients), and hypothyroid patients (8). Results: There was statistically significant correlation between 3 groups of thyroid hormone levels and BMI and myocardial infarction (MI). There was statistically non-significant differences between the 3 groups of thyroid functions(euthyroid, hyperthyroid and hypothyroidism) as regarded Age, Sex, Hypertension, DM, Coronary artery disease(CAD),Congestive heart failure (CHF), Blood diseases, PCI ,taking aspirin or warfarin, Ejection fraction, HbA1C, liver function tests, C-Reactive protein(CRP)level and Troponin marker. There was not a significant correlation between Syntax score and Age, International normalized ratio(INR), (Thyroid stimulating hormone)TSH level, Free Thyroxine (FT4), Ejection fraction and HbA1C.Syntax score was significantly inversely related to serum triiodothyronine (FT3) levels. In addition to its correlation with the syntax score, FT3 was shown to be a reliable predictor of CAD severity on its own. This suggests that FT3, rather than FT4 and TSH levels, may be utilized to predict the severity of CAD. Conclusion: FT3 levels below 2.65 nmol/L are a strong indicator of coronary artery lesion severity. A lower FT3 level is a continuous variable that may be utilized as a predictor of an increased risk for severe CAD.