Association of thyroid hormone with osteoarthritis: from mendelian randomization and RNA sequencing analysis
Chengxin Li,
Yucheng Tu,
Rong Rong
et al.
Abstract:Background
The relationship between thyroid hormone (TH) levels in vivo and osteoarthritis (OA) remains inconclusive. This study aims to investigate the association between TH levels and OA, analyze the effect of triiodothyronine on hypertrophic chondrocyte differentiation and OA progression, and identify potential target genes of triiodothyronine in OA to evaluate its diagnostic value.
Methods
Two-sample mendelian randomization method was used to … Show more
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