Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus

Kariž, Stojan; Mankoč, Sara; Petrovič, Daniel

doi:10.1016/j.diabres.2015.01.038

Cited by 19 publications

(11 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may indicate increased need for this protein in the cardiomyocytes in stressed context. Moreover, mutations TXNRD2 have been reported to cause DCM [75,76], while specific singlenucleotide polymorphisms (SNPs) can predispose patients to a higher risk of myocardial infarction [77].…”

Section: Oxidative Stress and Mitochondrial Dysfunctionmentioning

confidence: 99%

Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective

Al‐Mubarak

Meer

Bömer

2021

Curr Heart Fail Rep

View full text Add to dashboard Cite

Purpose of Review (Mal-)nutrition of micronutrients, like selenium, has great impact on the human heart and improper micronutrient intake was observed in 30–50% of patients with heart failure. Low selenium levels have been reported in Europe and Asia and thought to be causal for Keshan disease. Selenium is an essential micronutrient that is needed for enzymatic activity of the 25 so-called selenoproteins, which have a broad range of activities. In this review, we aim to summarize the current evidence about selenium in heart failure and to provide insights about the potential mechanisms that can be modulated by selenoproteins. Recent Findings Suboptimal selenium levels (<100 μg/L) are prevalent in more than 70% of patients with heart failure and were associated with lower exercise capacity, lower quality of life, and worse prognosis. Small clinical trials assessing selenium supplementation in patients with HF showed improvement of clinical symptoms (NYHA class), left ventricular ejection fraction, and lipid profile, while governmental interventional programs in endemic areas have significantly decreased the incidence of Keshan disease. In addition, several selenoproteins are found impaired in suboptimal selenium conditions, potentially aggravating underlying mechanisms like oxidative stress, inflammation, and thyroid hormone insufficiency. Summary While the current evidence is not sufficient to advocate selenium supplementation in patients with heart failure, there is a clear need for high level evidence to show whether treatment with selenium has a place in the contemporary treatment of patients with HF to improve meaningful clinical endpoints. Graphical abstract

show abstract

Section: Oxidative Stress and Mitochondrial Dysfunctionmentioning

confidence: 99%

Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective

Al‐Mubarak

Meer

Bömer

2021

Curr Heart Fail Rep

View full text Add to dashboard Cite

show abstract

“…H 2 O 2 in the mitochondria is reduced by thioredoxin which is then further reduced by TXNRD2 defending cells from H 2 O 2 -induced oxidative stress [135]. So far, polymorphisms in the TXNRD2 gene have been associated with various cancers [135], one reported study [135] testing rs1548357, rs4485648 and rs5748469 polymorphisms in relationship to MI in T2DM subjects proposed a positive association of CC and CT genotypes (rs1548357) (Table 5 ).…”

Section: Polymorphisms Of Superoxide Scavenger System Genesmentioning

confidence: 99%

“…So far, polymorphisms in the TXNRD2 gene have been associated with various cancers [135], one reported study [135] testing rs1548357, rs4485648 and rs5748469 polymorphisms in relationship to MI in T2DM subjects proposed a positive association of CC and CT genotypes (rs1548357) (Table 5 ). More studies are needed to determine the role of TXNRD2 in the pathogenesis of CAD in T2DM.…”

Section: Polymorphisms Of Superoxide Scavenger System Genesmentioning

confidence: 99%

Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus

Tibaut¹,

Petrovič

2016

CHAMC

View full text Add to dashboard Cite

The worldwide increasing prevalence of obesity and sedentary lifestyle is the main cause of the rising incidence of T2DM. Due to chronic macrovascular and microvascular complications, T2DM represent a huge socioeconomic burden in the world. Oxidative stress is a key pathogenic mechanism implicated in diabetic coronary artery disease (CAD). Polymorphisms of oxidative stress genes are known to influence oxidative stress levels and are therefore thought to impact CAD pathogenesis. Identifying higher risk groups would be rational, since it would allow better sample selection and thus better results in antioxidant trials. In this review, we summarize the evidence of oxidative stress gene polymorphisms related to the pathogenesis of CAD. Moreover, we provide a review of antioxidants tested in subjects with CAD.

show abstract

“…As oxidative stress is recognized as central pathogenic process in accelerated atherosclerosis in T2DM, various studies [7] investigated associations of oxidative stress genes (e.g. Nicotinamide Adenine Dinucleotide Phosphate (NADPH1) oxidase, Myeloperoxidase, Glutathione peroxidase 1, Glutathione Stransferase [30], NAD(P)H1: Quinone oxidoreductase (NQO1), Superoxide dismutase 1 and 2 [31], Thioredoxin reductase 2 [32], Uncoupling protein 2 [33], etc.) with micro-and macrovascular complications in T2DM.…”

Section: Discussionmentioning

confidence: 99%

Reactive Oxygen Species Modulator-1 (ROMO-1) Polymorphism Rs6060566 and The Risk of Myocardial Infarction in Slovenian Subjects With Type 2 Diabetes Mellitus

Tibaut

Ramuš

Petrovič

2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background We aimed to examine the role of the rs6060566 polymorphism of the reactive oxygen species modulator-1 (ROMO-1) gene in the development of myocardial infarction (MI) in Caucasians with type 2 diabetes mellitus (T2DM). Methods A total of 1072 subjects with T2DM were enrolled in cross-sectional case-control study: 335 subjects with MI and 737 subjects without clinical signs of coronary artery disease (CAD). Genetic analysis of the rs6060566 polymorphism was performed in all subjects. To assess the degree of coronary artery obstruction, a subpopulation of 128 subjects with T2DM underwent coronary computed tomography (CT) angiography. Next, endarterectomy samples were obtained during myocardial revascularization from diffusely diseased coronary arteries in 40 cases, which were analysed for ROMO-1 expression according to their genotype. Results There were no statistically significant associations between different genotypes or alleles of the rs6060566 polymorphism and MI in subjects with T2DM. The carriers of the C allele of the ROMO-1 rs6060566 had a threefold increased likelihood of having coronary artery stenosis (AOR = 3.27, 95% CI 1.16–9.20). Furthermore, the carriers of the C allele showed higher number of positive cells for ROMO-1 expression in endarterectomy samples of coronary arteries. Conclusions In accordance to our study, the rs6060566 polymorphism of the ROMO-1 gene is not the risk factor for MI in Caucasians with T2DM. However, we found that subjects carrying the C allele were at a 3.27-fold increased risk of developing severe CAD compared with those who had nonobstructive CAD. Moreover, The C allele carriers showed statistically higher number of cells positive for ROMO-1 compared with T allele carriers in coronary endarterectomy samples.

show abstract

Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus

Cited by 19 publications

References 40 publications

Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective

Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective

Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus

Reactive Oxygen Species Modulator-1 (ROMO-1) Polymorphism Rs6060566 and The Risk of Myocardial Infarction in Slovenian Subjects With Type 2 Diabetes Mellitus

Contact Info

Product

Resources

About