Association of the urinary polycyclic aromatic hydrocarbons with sex hormones stratified by menopausal status older than 20 years: a mixture analysis

Zhu, Xihui; Meng, Yancen; Ju, Yaru; Yang, Yonggang; Zhang, Su'e; Miao, Liye; Li, Zhan

doi:10.1007/s11356-023-26099-x

Cited by 3 publications

(2 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oestrogen has been reported to stimulate bone growth and maturation and inhibit bone resorption (Manolagas, 2013;Manolagas et al, 2002); therefore, the anti-estrogenic effects of PAH metabolites may diminish bone protection (Fang et al, 2023). Previous studies have found that urinary OH-PAH mixtures are associated with decreased TT and E 2 (Zhu et al, 2023). The association of the WQS index of the six OH-PAHs with periodontitis was stronger at low levels of TT or E 2 , and it can be speculated that this may be due to the combined effect of the inhibition of sex hormones by PAH exposure and the diminished protection of periodontal tissues by sex hormones.…”

Section: Discussionmentioning

confidence: 99%

Association between polycyclic aromatic hydrocarbons and periodontitis: Results from a large population‐based study

Wu,

Yang,

Jin

et al. 2023

J Clinic Periodontology

View full text Add to dashboard Cite

AimTo explore the association between polycyclic aromatic hydrocarbons (PAHs) (measured using urinary metabolites) and periodontitis using data from the National Health and Nutrition Examination Survey 2009–2014.Materials and MethodsWeighted binary logistic regression, Bayesian kernel machine regression (BKMR) and weighted quantile sum (WQS) regression were used to evaluate independent and joint associations between the six urinary monohydroxylated metabolites of PAHs (OH‐PAHs) and periodontitis.ResultsIn all, 3413 participants were included in this study. All six urinary OH‐PAHs were present at higher levels in the periodontitis group compared with the non‐periodontitis group (p < .001). Fully adjusted multivariable logistic regressions showed positive associations between the six urinary OH‐PAHs and periodontitis (p < .05). Higher concentrations of OH‐PAHs were also positively associated with attachment loss, periodontal pocket depth (PPD) and the number of tooth loss. BKMR and WQS regression yielded similar positive associations between OH‐PAH mixtures and periodontitis.ConclusionsPAHs and their mixture are positively associated with periodontitis, which may provide novel insights into periodontitis prevention from an environmental exposure perspective.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between polycyclic aromatic hydrocarbons and periodontitis: Results from a large population‐based study

Wu,

Yang,

Jin

et al. 2023

J Clinic Periodontology

View full text Add to dashboard Cite

show abstract

“…PAH metabolites in human urine can be utilized as internal dosage indicators to measure PAH exposure (23). At present, the associations between PAH exposure and sex hormone levels (e.g., reproductive hormones, estradiol, and serum testosterone) have been reported (24)(25)(26)(27), whereas no study has assessed the association between PAH exposure and the risk of endometriosis. Of note, individuals are exposed to various chemicals at the same time, resulting in a mixture exposure pattern.…”

Section: Introductionmentioning

confidence: 99%

Association between exposure to polycyclic aromatic hydrocarbons and endometriosis: data from the NHANES 2001–2006

Zhang,

Yang

2024

Front. Public Health

View full text Add to dashboard Cite

AimTo evaluate the association between urinary polycyclic aromatic hydrocarbon (PAH) metabolites and the risk of endometriosis.MethodsThis cross-sectional study obtained data on women aged 20–54 years from the National Health and Nutrition Examination Survey (NHANES) 2001–2006. The weighted multivariate logistic regression model was established to assess the association between the eight urinary PAH metabolites and the risk of endometriosis. In this multivariate analysis, the eight urinary PAH metabolites were adjusted with urinary creatinine, and were divided into three groups according to tertiles: Tertile 1, Tertile 2 and Tertile 3. To evaluate the overall association of mixed PAH metabolites with endometriosis, the Bayesian kernel machine regression (BKMR) model was applied.ResultsTotally 1,291 women were included, of which 90 (6.97%) had endometriosis and 1,201 (93.03%) did not have endometriosis. After adjusting for age, race, smoking, age at menarche, hysterectomy, ovary removed, female hormone use, and menopause, compared with the Tertile 1 group, the Tertile 2 and Tertile 3 groups of all PAH metabolites demonstrated no significant risk of endometriosis. A positive tendency was found between mixed PAH metabolites and endometriosis when all the metabolites were at their 60th percentile levels or above compared with their median levels. When all the other metabolites were fixed at their median levels, 1-hydroxynaphthalene was positively correlated with endometriosis. Potential interactions existed between 1-hydroxynaphthalene and 2-hydroxynaphthalene and between 2-hydroxyfluorene and 3-hydroxyfluorene.ConclusionNo significant association was found between individual PAH metabolites and endometriosis. A positive association existed between mixed PAH metabolites and the risk of endometriosis.

show abstract

Associations of urinary polycyclic aromatic hydrocarbon (PAH) metabolites and their mixture with thyroid hormone concentration during pregnancy in the LIFECODES cohort: A repeated measures study

Park,

Siwakoti,

Ferguson

et al. 2024

Environmental Research

View full text Add to dashboard Cite

Association of the urinary polycyclic aromatic hydrocarbons with sex hormones stratified by menopausal status older than 20 years: a mixture analysis

Cited by 3 publications

References 52 publications

Association between polycyclic aromatic hydrocarbons and periodontitis: Results from a large population‐based study

Association between polycyclic aromatic hydrocarbons and periodontitis: Results from a large population‐based study

Association between exposure to polycyclic aromatic hydrocarbons and endometriosis: data from the NHANES 2001–2006

Associations of urinary polycyclic aromatic hydrocarbon (PAH) metabolites and their mixture with thyroid hormone concentration during pregnancy in the LIFECODES cohort: A repeated measures study

Contact Info

Product

Resources

About