Association of the triglyceride-glucose index and vascular target organ damage in a Beijing community-based population

Abstract

ObjectiveWe aimed to explore the association between the triglyceride-glucose (TyG) index, a marker of insulin resistance (IR), and vascular target organ damage (TOD) in a Beijing community-based population, China.MethodsA total of 6,015 participants from an atherosclerosis cohort survey performed in the Shijingshan District in Beijing, China were included in our analysis. Vascular TOD, such as carotid-femoral pulse wave velocity (cfPWV), brachial-ankle pulse wave velocity (baPWV), and the urine albumin-to-creatinine ratio (UACR) were all evaluated.ResultsThe overall mean age of all the participants was 62.35 years, 3,951 (65.69%) were female, and mean TyG index was 8.81. In univariable regression analyzes, an increased TyG index was associated with higher cfPWV, baPWV, lnUACR, and higher risk of cfPWV ≥ 10 m/s, baPWV ≥ 1,800 cm/s, and UACR ≥ 30 mg/g, respectively. Multivariable regression analyzes showed subjects with the TyG index in top tertile had a significant increase in cfPWV (β = 0.29 m/s; 95% confidence interval [95% CI] 0.19–0.40; pfortrend < 0.001), baPWV (β = 69.28 cm/s; 95% CI 50.97–87.59; pfortrend < 0.001), lnUACR (β = 0.23; 95% CI 0.13–0.34; pfortrend < 0.001), and had a higher risk of cfPWV ≥ 10 m/s (odds ratio [OR] = 1.47; 95% CI 1.17–1.85; pfortrend < 0.001), baPWV ≥ 1,800 cm/s (OR = 1.79; 95% CI 1.48–2.17; pfortrend < 0.001), and UACR ≥ 30 mg/g (OR = 1.71; 95% CI 1.30–2.24; pfortrend < 0.001) after fully adjusting for age, sex, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), estimated glomerular filtration rate (eGFR), self-reported coronary heart disease (CHD) and stroke, antihypertensive drugs, hypoglycemic drugs, and lipid-lowering drugs. Consistent conclusions were obtained in the subgroups without hypoglycemic and lipid-lowering medications or aged younger than 65 years old.ConclusionsThe TyG index was positively associated with artery stiffness and nephric microvascular damage in a Beijing community-based population in China. This result provides evidence that the TyG index may serve as a simple and effective indicator to reflect vascular TOD.

Association between the triglyceride-glucose index and arterial stiffness: A meta-analysis

“…2A). Relatively similar outcomes were achieved in 10 studies in which the TyG index was treated as a continuous variable [22,24–28,31–34] (RR: 1.46, 95% CI: 1.32–1.61, I 2 = 77%, P < .001; Fig. 2B).…”

“…Twelve were officially published in journals, [22][23][24][25][26][27][28][29][30][31]33,34] and 1 was presented as a preprint on the Research Square website. [32] The studies were conducted in China, [22,24,[27][28][29][30][31][32]34] Korea, [23] Japan, [25,33] and the USA. [26] Two were prospective cohort studies, [29,32] while the other 11 were cross-sectional studies.…”

“…Lee 2018 [23] men 1.77 1.41-2.22 72 <.001 Lee 2018 [23] women 1.86 1.46-2.38 77 <.001 Li 2020 [24] 1.67 1.44-1.93 23 <.001 Su 2021 [27] 1.87 1.46-2.39 77 <.001 Wang 2021 [28] 1.92 1.50-2.46 75 <.001 Wu 2021 [29] 1.91 1.47-2.47 76 <.001 Zhao 2019 [30] 1.94 1.52-2.47 73 <.001 Wu 2020 [32] 1.92 1.49-2.46 76 <.001 Yang 2022 [33] 1.87 1.47-2.38 77 <.001 Ji 2022 [34] 1.86 1.49-2.33 74 <.001 CI = confidence interval, RR = risk ratio, TyG = triglyceride-glucose.…”

Association between triglyceride glucose index and arterial stiffness and coronary artery calcification: a systematic review and exposure-effect meta-analysis

“…1 ) [ 11 , 22 – 26 ]. Finally, ten cohort studies[ 14 , 27 – 35 ] and sixteen cross-sectional [ 9 , 15 , 36 – 49 ] studies were included in the present research, while the detailed reasons for the excluded articles are listed in Additional file 1 : Table S3.

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“…Table 1 presents the baseline characteristics of the included studies, which were published between 2017 and 2022, with a sample size ranging from 180 to 13,706 and a total of 87,307 participants. Among the included studies, 15 were from China[ 9 , 14 , 15 , 28 , 29 , 31 , 33 , 34 , 36 , 40 , 42 , 44 , 45 , 47 , 50 ], seven were conducted in Korea [ 27 , 30 , 34 , 35 , 37 – 39 ], three were from [ 42 , 48 , 49 ] Japan [ 41 , 47 , 49 ], and only one originated in non-Asia (United States) [ 43 ]. The mean age of participants ranged from 28.7 to 75 years, and the BMI ranged from 22.5 to 28.5 kg/m 2 .…”