Association of the TNF-α, IL-2, and IL-2RB gene variants with susceptibility to psoriasis in a Turkish cohort

Abstract

Aim of the studyThe aim of this study was to investigate the role TNF-α, IL-2, and IL-2RB variants in psoriasis (Ps) and to evaluate the association between these variants and clinical features.Material and methodsA total of 74 psoriatic patients and 74 healthy individuals were genotyped for these variants by PCR and/or RFLP.ResultsThe AA genotype of TNF-α (–308) was significantly more common in the patients (p = 0.013). TNF-α (–238) AA genotype was significantly increased in the patients (p = 0.028), while the GG genotype was decreased in the patient group, compared to the controls (p = 0.016). IL-2 (–330) variant GG and TT genotype was more common in the patients (p = 0.037, p = 0.009, respectively), while IL-2 (–330) GT genotype was increased in the control subjects (p = 0.001). IL-2 (–330) GG genotype frequency was significantly decreased (p = 0.021) and the TT genotype frequency was significantly increased among patients with psoriatic arthritis in comparison with Ps patients (p = 0.014). IL-2RB TC genotype frequency was significantly decreased and TT genotype frequency was significantly increased in the patients with positive family history of Ps compared to those who had a negative family history (p = 0.017, p = 0.014, respectively). Also, IL-2RB CC genotype was significantly increased among the patients with late-onset Ps in comparison with the early onset Ps group (p = 0.009). The frequency of IL-2 (–330) TT genotype was significantly higher in mild Ps patients than moderate-severe patients (p = 0.043).ConclusionsOur data suggest a potential role of these genes as candidate genes for susceptibility to Ps in a Turkish cohort.

Association between tumor necrosis factor-alpha polymorphisms (rs361525, rs1800629, rs1799724, 1800630, and rs1799964) and risk of psoriasis in studies following Hardy-Weinberg equilibrium: A systematic review and meta-analysis

“…Table 1 illustrates the studies including −238 G/A rs361525 polymorphism. Out of 24 articles [ 20 , 21 , [23] , [24] , [25] , [26] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] ] that include 26 studies, fourteen studies were reported in Caucasians, eight in Asians, and four in mixed populations. Out of 26 studies, thirteen studies reported patients with psoriasis vulgaris, eight with psoriatic arthritis, four with psoriasis, and one with generalized pustular psoriasis.…”

“…Several studies have investigated the relationship of single nucleotide polymorphism (SNP) of rs 361525 , rs 1800629 , rs 1799724 , 1800630 , and rs 1799964 in psoriasis cases compared to controls with different results [ [20] , [21] , [22] , [23] , [24] , [25] , [26] ]. Six meta-analyses [ [27] , [28] , [29] , [30] , [31] , [32] ] reported TNF-α polymorphisms in psoriasis cases.…”

The effect of ACE2 receptor, IFN-γ, and TNF-α polymorphisms on the severity and prognosis of the disease in SARS-CoV-2 infection

“…48 TNF-a gene variants have been widely studied and previous findings show relationships between TNF-a gene variants and the development of autoimmune diseases, infectious diseases, and cancer. 49,50 In the present study, TNF-a gene polymorphisms were studied in SARS-CoV-2 infection. Only the c.27C.T variant of the TNF gene was seen in one patient with mild clinical manifestations.…”

Circulating inflammatory cytokines and psoriasis risk: A systematic review and meta-analysis

“…IL-2 is a cell growth factor with various immunoregulatory functions and biological characteristics, secreted mostly by activated helper T lymphocytes [ 71 , 72 ]. Elevated serum IL-2 levels are associated with significant disease progression in many autoimmune diseases and cancers, including melanoma, autoimmune hepatitis, and systemic lupus erythematosus [ 73 , 74 ].…”